Blar i Faculty of Medicine på tittel
Viser treff 6915-6934 av 8763
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Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy—The Randomized NORDIC9-Study
(Journal article; Peer reviewed, 2021)Bowel cancer is one of the leading cancer-types in both sexes worldwide. Despite that most new cases and deaths occur in people aged 70 years or older, few clinical trials have investigated the best way to administer ... -
Quality of life of women living with metastatic breast cancer and receiving palliative care: A systematic review
(Journal article; Peer reviewed, 2021)The quality of life (QoL) of women living with metastatic breast cancer and receiving palliative care needs more attention. We reviewed published studies (1992–2019) examining QoL of women receiving palliative care. The ... -
Quality of life, functional status and cost-effectiveness of treatment after femoral shaft fractures in Malawi. A comparison of skeletal traction and intramedullary nailing in a low resource setting.
(Doctoral thesis, 2021-03-26)Introduction: The incidence of femoral shaft fractures in Low- and Middle-Income Countries(LMICs) ranges from 15.7 to 45.5 per 100,000 people per year. A recent study in Malawi, a low-income country (LIC), estimated the ... -
Quality of municipal drinking water and the risk of osteoporotic fractures in Norway
(Doctoral thesis, 2014-06-02)Background: For mainly unknown reasons, the Norwegian population has among the highest incidence rates of osteoporotic fractures in the world. The risk of fracture has been shown to vary within Norway, with higher risks ... -
Quality of primary care from the patient perspective in South West Malawi : Development and application of the Malawian Primary Care Assessment Tool (Pcat-Mw)
(Doctoral thesis, 2020-02-06)Background Primary care is considered as a vehicle for accelerating progress towards universal health coverage and for building efficient, effective, and integrated healthcare systems. Measuring patients’ experience and ... -
Quality of warfarin therapy and quality of life are improved by self-management for two years
(Peer reviewed; Journal article, 2019)Background: Studies from several countries show that self-management of vitamin K antagonist (e.g., warfarin) therapy reduce the risk of complications compared with conventional management. Objectives: The aim of this study ... -
Quantification of the concentration gradient of biomarkers between ovarian carcinoma interstitial fluid and blood
(Peer reviewed; Journal article, 2014-12)Background: Tumor interstitial fluid (TIF) rather than plasma should be used in cancer biomarker discovery because of the anticipated higher concentration of locally produced proteins in the tumor microenvironment. ... -
Quantifying tumour vascularity in non-luminal breast cancers
(Peer reviewed; Journal article, 2017)Aims: Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ... -
Quantitative analogues to visual spike interpretation in EEG
(Doctoral thesis, 2024-05-03)Bakgrunn: Noen skarpe transienter i EEG er interiktale epileptiforme utladninger (IEU) og representerer en biomarkør for epilepsi. Visuell analyse er den gjeldende gullstandarden for å detektere IEUer. En slik analyse ... -
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
(Peer reviewed; Journal article, 2016-08-05)Background: Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we ... -
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
(Peer reviewed; Journal article, 2013-10-05)Background: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation ... -
Quantitative PCR Measurement of miR-371a-3p and miR-372-p Is Influenced by Hemolysis
(Peer reviewed; Journal article, 2019-05-22)Cell-free microRNAs have been reported as biomarkers for several diseases. For testicular germ cell tumors (GCT), circulating microRNAs 371a-3p and 372-3p in serum and plasma have been proposed as biomarkers for diagnostic ... -
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
(Journal article; Peer reviewed, 2022)Background Tandem mass tag spectrometry (TMT labeling-LC-MS/MS) was utilized to examine the global proteomes of Atlantic halibut eggs at the 1-cell-stage post fertilization. Comparisons were made between eggs judged to ... -
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
(Peer reviewed; Journal article, 2019-05-08)Background Multiple sclerosis (MS) is an autoimmune, neuroinflammatory disease, with an unclear etiology. However, T cells play a central role in the pathogenesis by crossing the blood–brain-barrier, leading to inflammation ... -
Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients
(Peer reviewed; Journal article, 2013-04-29)Background: There is little knowledge concerning the content and the mechanisms of filling of arachnoid cysts. The aim of this study was to compare the protein content of arachnoid cysts and cerebrospinal fluid by quantitative ... -
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls
(Journal article; Peer reviewed, 2022-07-05)Background: Multiple sclerosis (MS) is an autoimmune, neurodegenerative disorder with a strong genetic component that acts in a complex interaction with environmental factors for disease development. CD4+ T cells are pivotal ... -
Quantitative pupillometry in comatose out-of-hospital cardiac arrest patients: A post-hoc analysis of the TTH48 trial
(Journal article; Peer reviewed, 2022)Background: Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological pupil index (NPi) scale from 0 to 5. The aim of the present sub-study was to ... -
Quantitative User Data From a Chatbot Developed for Women With Gestational Diabetes Mellitus: Observational Study
(Journal article; Peer reviewed, 2022)Background: The rising prevalence of gestational diabetes mellitus (GDM) calls for the use of innovative methods to inform and empower these pregnant women. An information chatbot, Dina, was developed for women with GDM ... -
The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity
(Journal article; Peer reviewed, 2019)Tyrosine hydroxylase (TH) is a multi-domain, homo-oligomeric enzyme that catalyses the rate-limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive ...