Blar i Faculty of Medicine på tittel
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Tanzania national survey on iodine deficiency: impact after twelve years of salt iodation
(Peer reviewed; Journal article, 2009-09-03)Background: In many low-income countries, children are at high risk of iodine deficiency disorders, including brain damage. In the early 1990s, Tanzania, a country that previously suffered from moderate to severe iodine ... -
Target Values and Daytime Variation of Bone Turnover Markers in Monitoring Osteoporosis Treatment After Fractures
(Journal article; Peer reviewed, 2022)The serum bone turnover markers (BTM) procollagen type 1 N-terminal propeptide (P1NP) and C-terminal cross-linking telopeptide of type 1 collagen (CTX) are recommended for monitoring adherence and response of antiresorptive ... -
Target weight gain for moderately wasted children during supplementation interventions – a population-based approach
(Peer reviewed; Journal article, 2011-12)Objective: In malnourished populations, the weight-for-height Z-score (WHZ) distribution is shifted to the left. The aim of nutrition interventions should be to restore a normal WHZ distribution for the whole population. ... -
Targeted Next-Generation Sequencing of Cancer-Related Genes in a Norwegian Patient Cohort With Head and Neck Squamous Cell Carcinoma Reveals Novel Actionable Mutations and Correlations With Pathological Parameters
(Journal article; Peer reviewed, 2021)Background: Targeted next-generation sequencing (NGS) is increasingly applied in clinical oncology to advance personalized treatment. Despite success in many other tumour types, use of targeted NGS panels for assisting ... -
Targeted proteomics in a population-based study identifies serum PECAM-1 and TRIM21 as inflammation markers for periodontitis
(Journal article; Peer reviewed, 2023)Objectives Periodontitis (PD) can cause systematic inflammation and is associated with various metabolic processes in the body. However, robust serum markers for these relationships are still lacking. This study aims ... -
Targeted temperature management in cardiac arrest: survival evaluated by propensity score matching
(Peer reviewed; Journal article, 2017)Background: Targeted temperature management in cardiac arrest was introduced following evidence of increased survival from two controlled trials published in 2002. We wanted to investigate whether the introduction of ... -
Targeting APLN/APLNR improves antiangiogenic efficiency and blunts proinvasive side effects of VEGFA/VEGFR2 blockade in glioblastoma
(Peer reviewed; Journal article, 2019)Antiangiogenic therapy of glioblastoma (GBM) with bevacizumab, a VEGFA-blocking antibody, may accelerate tumor cell invasion and induce alternative angiogenic pathways. Here we investigate the roles of the proangiogenic ... -
Targeting condom distribution at high risk places increases condom utilization-evidence from an intervention study in Livingstone, Zambia
(Peer reviewed; Journal article, 2012-01-05)Background: The PLACE-method presumes that targeting HIV preventive activities at high risk places is effective in settings with major epidemics. Livingstone, Zambia, has a major HIV epidemic despite many preventive efforts ... -
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
(Peer reviewed; Journal article, 2013-09-09)Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet need ... -
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
(Journal article; Peer reviewed, 2020)Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to ... -
Targeting the AKT Pathway in Glioblastoma Multiforme
(Master thesis, 2016-06-01)In this study, the therapeutic efficacy of AKT allosteric and ATP competitive inhibitors was investigated in EGFR-amplified SKMG-3 and EGFR-low U-87 cell lines. The IC50 values of AKT inhibitors were determined by cellular ... -
Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
(Doctoral thesis, 2013-06-19)Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. The patients’ median survival is only 14.6 months despite multimodal treatment, including surgery and concomitant radiation and chemotherapy. ... -
Targeting the Class A Carbapenemase GES-5 via Virtual Screening
(Journal article; Peer reviewed, 2020)The worldwide spread of β-lactamases able to hydrolyze last resort carbapenems contributes to the antibiotic resistance problem and menaces the successful antimicrobial treatment of clinically relevant pathogens. Class A ... -
Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma
(Peer reviewed; Journal article, 2011-07-29)Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with an aggressive disease course in several malignancies including ... -
Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention
(Journal article; Peer reviewed, 2022)Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. Here, ... -
Task-based functional connectivity reveals aberrance with the salience network during emotional interference in late-life depression
(Journal article; Peer reviewed, 2023)Objectives Late-life depression (LLD) is a common and debilitating disorder. Previously, resting-state studies have revealed abnormal functional connectivity (FC) of brain networks in LLD. Since LLD is associated with ... -
Task-Shifting and Quality of HIV Testing Services: Experiences from a National Reference Hospital in Zambia
(Peer reviewed; Journal article, 2015-11-25)Background: With new testing technologies, task-shifting and rapid scale-up of HIV testing services in high HIV prevalence countries, assuring quality of HIV testing is paramount. This study aimed to explore various cadres ... -
Teacher ratings of mental health among school children in Kinshasa, Democratic Republic of Congo
(Peer reviewed; Journal article, 2005)Introduction: In Africa, little is known about child mental health. This study piloted the Strengths and Difficulties Questionnaire (SDQ) in Kinshasa, investigated mental health problems and the association between these ... -
Teaching geriatric medicine through gamification: a tool for enhancing postgraduate education in geriatric medicine
(Journal article; Peer reviewed, 2022)Background Polypharmacy is becoming increasingly common and all doctors must be prepared to manage it competently. Aims The aim of this project is to evaluate the feasibility and use of a novel gamification-based ...