Blar i Faculty of Medicine på tittel

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    • Whole genome sequencing of clinical isolates of Giardia lamblia 

      Hanevik, Kurt; Bakken, R.; Brattbakk, Hans-Richard; Saghaug, Christina Skår; Langeland, Nina (Peer reviewed; Journal article, 2015-10-29)
      Clinical isolates from protozoan parasites such as Giardia lamblia are at present practically impossible to culture. By using simple cyst purification methods, we show that Giardia whole genome sequencing of clinical stool ...

    • Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia 

      Malcher, Agnieszka; Stokowy, Tomasz; Berman, Andrea; Olszewska, Marta; Jedrzejczak, Piotr; Sielski, Dawid; Nowakowski, Adam; Rozwadowska, Natalia; Yatsenko, Alexander N.; Kurpisz, Maciej K. (Journal article; Peer reviewed, 2022)
      Background: Genetic causes that lead to spermatogenetic failure in patients with nonobstructive azoospermia (NOA) have not been yet completely established. Objective: To identify low-frequency NOA-associated single ...

    • Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer 

      Fasmer, Kristine Eldevik; Hodneland, Erlend; Dybvik, Julie Andrea; Wagner-Larsen, Kari Strøno; Trovik, Jone; Salvesen, Øyvind; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2021)
      Background In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI‐based radiomic tumor profiling may aid in ...

    • Why caretakers bypass Primary Health Care facilities for child care - a case from rural Tanzania 

      Kahabuka, Catherine; Kvåle, Gunnar; Moland, Karen Marie; Hinderaker, Sven Gudmund (Peer reviewed; Journal article, 2011-11-17)
      Background: Research on health care utilization in low income countries suggests that patients frequently bypass PHC facilities in favour of higher-level hospitals - despite substantial additional time and financial costs. ...

    • Why do doctors in Norway choose general practice and remain there? A qualitative study about motivational experiences 

      Gronseth, Inga Marthe; Malterud, Kirsti; Nilsen, Stein (Journal article; Peer reviewed, 2020-05-12)
      Objective: To explore experiences motivating doctors to become and remain GPs. Design and contributors: Qualitative analysis of written responses from an open-ended question about motivational experiences posted on an ...

    • Why do health workers in rural Tanzania prefer public sector employment? 

      Songstad, Nils Gunnar; Moland, Karen Marie; Massay, Deodatus Amadeus; Blystad, Astrid (Peer reviewed; Journal article, 2012-04-05)
      Background: Severe shortages of qualified health workers and geographical imbalances in the workforce in many low-income countries require the national health sector management to closely monitor and address issues related ...

    • Why do some countries approve a cancer drug and others don’t? 

      Pujolras, Laia Maynou; Cairns, John Alexander (Peer reviewed; Journal article, 2015-06)
      The term drug reimbursement describes the policy system that determines whether or not a drug is entitled to reimbursement within the healthcare system. Countries make different decisions regarding which cancer treatments ...

    • Why several truths can be true 

      Meland, Eivind; Brodersen, John (Peer reviewed; Journal article, 2016)
      In this paper, we offer a perspective on complementarity, acknowledging that it is not possible for human perception and cognition to grasp reality with unambiguous concepts or theories. Therefore, multiple concepts and ...

    • Why teach sexuality education in school? Teacher discretion in implementing comprehensive sexuality education in rural Zambia 

      Zulu, Joseph M.; Blystad, Astrid; Haaland, Marte Emilie Sandvik; Michelo, Charles; Haukanes, Haldis; Moland, Karen Marie (Peer reviewed; Journal article, 2019-09-27)
      Background: Reproductive health problems such as HIV, unwanted pregnancy and unsafe abortion among adolescents are closely linked to insufficient knowledge about sexuality and reproduction and lack of access to contraceptives. ...

    • Why the Norwegian 2021 guideline for basic life support are different 

      Bjørshol, Conrad Arnfinn; Nordseth, Trond; Kramer-Johansen, Jo (Journal article; Peer reviewed, 2023)

    • The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples 

      Barrett, James E.; Herzog, Chiara; Jones, Allison; Leavy, Olivia C.; Evans, Iona; Knapp, Susanne; Reisel, Daniel; Nazarenko, Tatiana; Kim, Yoo-Na; Franchi, Dorella; Ryan, Andy; Franks, Joanna; Bjørge, Line; Zikan, Michal; Cibula, David; Harbeck, Nadia; Colombo, Nicoletta; Dudbridge, Frank; Jones, Louise; Sundström, Karin; Dillner, Joakim; Rådestad, Angelique Flöter; Gemzell-Danielsson, Kristina; Pashayan, Nora; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome ...

    • Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. 

      Maag, Jesper L.V.; Kaczorowski, Dominik C.; Panja, Debabrata; Peters, Timothy J.; Bramham, Clive R.; Wibrand, Karin; Dinger, Marcel E. (Peer reviewed; Journal article, 2017-03-23)
      Background: DNA methylation is a key modulator of gene expression in mammalian development and cellular differentiation, including neurons. To date, the role of DNA modifications in long-term potentiation (LTP) has not ...

    • Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes 

      Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha; Chen, Chi-Hua; Kuperman, Joshua M.; Hagler, Donald J.; Steen, Vidar Martin; Le Hellard, Stephanie; Håberg, Asta; Espeseth, Thomas; Andreassen, Ole Andreas; Dale, Anders; Jernigan, Terry L.; Halgren, Eric (Peer reviewed; Journal article, 2018-06-08)
      Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had ...

    • Wireless motility capsule compared with scintigraphy in the assessment of diabetic gastroparesis 

      Sangnes, Dag André; Søfteland, Eirik; Bekkelund, Mattis; Frey, Jakub; Biermann, Martin; Gilja, Odd Helge; Dimcevski, Georg Gjorgji (Peer reviewed; Journal article, 2019-12-30)
      Background: Gastroparesis is a potentially severe late complication of diabetes mellitus. Today, delayed gastric emptying (GE) is mandatory for establishing the diagnosis. In this study, we compared wireless motility capsule ...

    • Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects 

      Coşkun, Abdurrahman; Carobene, Anna; Aarsand, Aasne K.; Aksungar, Fehime B.; Serteser, Mustafa; Sandberg, Sverre; Díaz-Garzón, Jorge; Fernandez-Calle, Pilar; Karpuzoglu, Fatma H.; Coskun, Cihan; Klzllkaya, Emine; Fidan, Damla; Jonker, Niels; Ugur, Esra; Unsal, Ibrahim (Journal article; Peer reviewed, 2022)
      Objectives: Trace elements (TrEL) are nutritionally essential components in maintaining health and preventing diseases. There is a lack of reliable biological variation (BV) data for TrELs, required for the diagnosis and ...

    • Within- and between-subject biological variation data for tumor markers based on the European Biological Variation Study 

      Coşkun, Abdurrahman; Aarsand, Aasne Karine; Sandberg, Sverre; Guerra, Elena; Locatelli, Massimo; Díaz-Garzón, Jorge; Fernandez-Calle, Pilar; Ceriotti, Ferruccio; Jonker, Niels; Bartlett, William A.; Carobene, Anna (Journal article; Peer reviewed, 2022)
      Objectives: Reliable biological variation (BV) data are required for the clinical use of tumor markers in the diagnosis and monitoring of treatment effects in cancer. The European Biological Variation Study (EuBIVAS) was ...

    • Within-person reproducibility of proteoforms related to inflammation and renal dysfunction 

      Gao, Jie; McCann, Adrian; Laupsa-Borge, Johnny; Nygård, Ottar Kjell; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2022)
      Protein biomarkers and microheterogeneity have attracted increasing attention in epidemiological and clinical research. Knowledge of within-person reproducibility over time is paramount to determine whether a single ...

    • Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 

      Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Naess, Øyvind; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Journal article; Peer reviewed, 2022)
      Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...

    • Women empowerment and access to maternity and reproductive healthcare in Pakistan: cross-validation of a Survey-based Index in Afghanistan (SWEI-A) 

      Dadras, Omid; Dadras, Mohammadyasin; Jafari, Leila; Nakayama, Takeo; Dadras, Fateme (Journal article; Peer reviewed, 2022)
      Background Despite the obvious violation of women’s rights in Pakistan and the vital necessity for women empowerment, a unified country-specific index measuring women empowerment is not yet available. This study cross-validated ...

    • Women's experiences when unsure about whether or not to have an abortion in the first trimester 

      Kjelsvik, Marianne; Sekse, Ragnhild Johanne Tveit; Moi, Asgjerd Litleré; Aasen, Elin Margrethe; Chesla, Catherine A.; Gjengedal, Eva (Peer reviewed; Journal article, 2018)
      Abortion during the first trimester is legal in most Western countries. However, deciding to terminate a pregnancy is a challenging process, and some women arrive at the abortion clinic still not absolutely certain. We ...