Browsing Department of Biomedicine by Document Types "Doctoral thesis"
Now showing items 1-20 of 64
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Abrogation of Anthracycline and Ischemia-Reperfusion Induced Injury by Cell Signaling Modulators
(Doctoral thesis, 2013-10-18)Chemotherapy has a long history in cancer treatment, and the anthracycline used in Paper I and II are among the most effective anti-cancer drugs developed. Unfortunately, the use of anthracyclines is dose-restricted due ... -
Attention-Deficit/Hyperactivity Disorder in adults. Clinical characteristics and pre- and perinatal risk factors
(Doctoral thesis, 2011-01-28)Attention-deficit/hyperactivity disorder (ADHD) is currently a prevalent diagnosis in child psychiatry, typically affecting 2-5 % of school-aged children world-wide. The recent and increasing awareness that ADHD may persist ... -
Attention-deficit/hyperactivity disorder; sex differences in psychiatric comorbidity and transgenerational recurrence risks : A population-based study using Norwegian registry data
(Doctoral thesis, 2020-02-07)Background: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous, multifactorial and life-spanning neurodevelopmental disorder for which the underlying mechanisms and causes are not fully understood. Psychiatric ... -
Biomedical Image Processing in the Study of Living Cells
(Doctoral thesis, 2008-12-09) -
Cellular responses to metabolic stress. A study on the role of mitochondria in the crosstalk between cell metabolism and survival signaling
(Doctoral thesis, 2012-08-31)Metabolic imbalance is associated with increased risk of several diseases, including cancer. Metabolism affects or is affected by virtually all other cellular processes, which is not surprising considering their conserved ... -
The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach
(Doctoral thesis, 2019-04-12)Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively). Myelin insulates axons, which increases nerve conduction ... -
Characterization of the PLP-dependent decarboxylases GADL1 and CSAD
(Doctoral thesis, 2022-03-31)Pyridoxal 5’-phosphate (PLP) -dependent enzymes constitute an essential superfamily of enzymes for all living organisms. Due to the chemistry of their cofactor, PLP, these enzymes catalyze a wide variety of reactions. ... -
Chronic mild stress - an anmial model of depression : from behavior to molecules
(Doctoral thesis, 2006-11-03) -
Cognitive and psychosocial problems in children with epilepsy : a population-based approach
(Doctoral thesis, 2007-01-12) -
Digital reconstruction, quantitative morphometric analysis, and membrane properties of bipolar cells in the rat retina.
(Doctoral thesis, 2021-09-29)A basic principle of neuroscience is that structure reflects function. This has led to numerous attempts to characterize the complete morphology of types of neurons throughout the central nervous system. The ability to ... -
The effects of ageing on microenvironment-contextual epithelial cell signalling
(Doctoral thesis, 2018-04-06)Age is the greatest risk factor for developing cancer. Two-thirds of cancer diagnoses occur in people over the age of 65. This increased vulnerability to tumourigenesis is attributed to intrinsic cellular changes, in ... -
Effects of oil compounds and persistent organic pollutants (POPs) on phospholipid composition in liver and brain of Atlantic cod (Gadus morhua)
(Doctoral thesis, 2012-10-12)The work in this thesis is part of a project led by the Institute of Marine Research (IMR), with partners at the Department of Biomedicine (University of Bergen, UiB), the National Institute of Nutrition and Seafood Research ... -
Evolution of structure and function in Phenylalanine Hydroxylase. With the regulatory properties in sight
(Doctoral thesis, 2008-11-07)In the post-genomic era, an idea of how similar the genomes of different species actually are is on the horizon. Less than 10 years ago, the human genome was estimated to encode 100000 genes. That was an overestimation, ... -
Excitatory and inhibitory signaling in the rod pathway of the retina: Functional properties and activation of synaptic and extrasynaptic receptors
(Doctoral thesis, 2021-01-29)The visual system is arguably one of the most complex and studied sensory systems. The processing of visual information starts in the retina, where photoreceptors transduce light stimuli (photons) to electrochemical signals ... -
Experimental modeling and novel therapeutic strategies in melanoma brain metastasis
(Doctoral thesis, 2015-06-09)Melanoma patients carry a high risk of developing brain metastases and improvements in survival are still measured in weeks or months. The aim of this thesis was to study the biology of melanoma brain metastasis and find ... -
Exploring and exploiting the potential of pelvic IMRT to spare the bowel
(Doctoral thesis, 2011-10-28) -
Expression and effects of IL-1 and TNF-α in different experimental models of dental inflammation
(Doctoral thesis, 2006-07-04) -
EXT proteins: Role in heparan sulfate Assembly and in Tumor biology
(Doctoral thesis, 2018-08-24)The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi ... -
Function and regulation of phenylalanine and tyrosine hydroxylases from human and Caenorhabditis elegans. With focus in evolutionary aspects and development of new therapies
(Doctoral thesis, 2010-06-11)The family of the aromatic amino acid hydroxylases (AAAH) is well studied in mammals. It includes four members, i.e. phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and 2). ... -
Functionalization of Nanoparticles with Tyrosine Hydroxylase : Biotechnological and Therapeutic Implications
(Doctoral thesis, 2022-09-30)Tyrosine hydroxylase (TH) er et viktig enzym for nervesystemet, fordi det katalyserer det første steget i syntesen av dopamin, noradrenalin og adrenalin. Nivået på TH og dopamin synker hos Parkinsons pasienter pga. den ...