Blar i Department of Biomedicine på dokumenttype "Doctoral thesis"
Viser treff 21-40 av 61
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Functions and Regulation of eukaryotic NAD kinase - an essential enzyme for NADP biosynthesis
(Doctoral thesis, 2008-02-15)NAD and NADP, both major carriers of cellular reducing equivalents, are of vital importance in diverse metabolic and signaling processes. Efficient maintenance and regulation of the reduction-oxidation status is therefore ... -
Human tyrosine hydroxylase: Oxygen dependence and role in Dopa responsive dystonia
(Doctoral thesis, 2016-10-07)The aromatic amino acid hydroxylases (AAHs); phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase 1 and 2 (TPH 1/TPH 2); are structurally and functionally related enzymes. All AAHs require ... -
Identifying and characterizing novel invasion-related genes in Glioblastoma
(Doctoral thesis, 2022-03-25)Glioblastoma (GBM) represents the most devastating brain tumor in adults. Its characteristic ability to extensively invade into healthy brain structures forms a major challenge in regard to treatment as these diffusely ... -
Immunological mechanisms of tumour progression. The rationale for natural killer cell based immunotherapy for glioblastoma
(Doctoral thesis, 2013-10-04)Glioblastoma (GBM) is the most frequent and malignant brain tumour, where the patients’ median survival after diagnosis is only 14.6 months. Therefore, concerted research is required to develop novel treatments that will ... -
Impact of marine oils in inflammatory bowel disease and psoriatic arthritis. With focus on effects of seal oil and whale oil on joint pain
(Doctoral thesis, 2009-09-25)The Western diet has changed significantly over the last century, e.g. by an increased ratio of omega-6 (n-6) to n-3 polyunsaturated fatty acids (PUFA), particularly due to an increase in the use of vegetable oils like soy ... -
Inflammatory targeted assessment and laser treatment of knee osteoarthritis : Rater reliability of pain pressure threshold algometry and effectiveness of Low-Level Laser Therapy
(Doctoral thesis, 2022-11-03)Bakgrunn: Ved kneartrose er et høyere nivå av inflammasjon assosiert med mer intens smerte og raskere sykdomsprogresjon. Å redusere kneinflammasjon anbefales derfor som behandlingsmål. Inflammatorisk mediert hyperalgesi ... -
Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of the receptor tyrosine kinase AXL
(Doctoral thesis, 2017-11-17)Cancer is a major health issue all over the world. Cancer related deaths are one of the major causes of deaths, and are in > 90 % of the cases related to metastatic development, and spread of the cancer outside the primary ... -
LTP mechanisms in the dentate gyrus in vivo: BDNF signaling, translation control, and gene function
(Doctoral thesis, 2007-03-30) -
Mechanistic Insight and Translational Possibilities of Obesity-Breast Cancer Connection
(Doctoral thesis, 2021-12-07)Obesity is an independent risk factor for more than thirteen cancer types. In breast cancer context, obesity is strongly associated with higher incidence and poorer prognosis in postmenopausal patients. The management of ... -
Melanoma brain metastatis. Animal models, detection and therapy interventions
(Doctoral thesis, 2013-12-11) -
The microenvironment in human ovarian carcinoma - characterization through proteomic analysis of tissue interstitial fluid
(Doctoral thesis, 2013-10-11)The interstitial fluid of tissues and that of tumors in particular, represents the secretome and is thus a valuable source of tissue-specific proteins. The differential expression of proteins that are secreted in tumor ... -
Monoamine synthesis in neurometabolic disorders affecting catecholaminergic functioning: biochemical mechanisms and treatment implications
(Doctoral thesis, 2024-02-14)Løpet av de siste 100 år er det oppdaget hundrevis av arvelige metabolske forstyrrelser. Slike tilstander har ofte recessiv Mendelsk arv og kalles også medfødte metabolismefeil. Symptomene debuterer vanligvis like etter ... -
Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity
(Doctoral thesis, 2012-02-02)Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ... -
Multimodal Imaging of Physiologic Changes Induced by Anti-Angiogenic Therapy in Glioblastoma
(Doctoral thesis, 2014-12-18)Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumors. The standard of care for this disease consists in surgical resection, followed by radiotherapy and chemotherapy. Yet, the infiltrative ... -
New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia
(Doctoral thesis, 2007-12-18)Anthracyclines have been first line drugs for more than 3 decades in the treatment of acute myelogenous leukemia (AML). Even though the mechanism of action of anthracyclines has been extensively studied over the years, ... -
Novel Insights into Integrin α11 Expression and Function
(Doctoral thesis, 2020-01-31)Integrins are a major group of cell surface receptors, which link the extracellular matrix with the cell cytoskeleton. They are heterodimeric proteins consisting of non- covalently bound α- and β-subunits. By regulating ... -
Nuclear Receptor Genes - Regulation and Evolution
(Doctoral thesis, 2016-02-26)Nuclear receptors are transcription factors that typically bind ligands in order to regulate the expression level of their target genes. Members of this family work with their co-regulators and repressors to maintain a ... -
Nutritional properties of protein sources on diet-induced obesity, hepatic lipid accumulation, and fatty acid composition in mice
(Doctoral thesis, 2018-10-26)The prevalence of obesity has increased rapidly, and excess adiposity is associated with comorbidities that increase the risk of mortality. An energy-dense diet that is high in sugar and fat is one of the major explanations ... -
Personality traits, risk factors and comorbidities in Attention-deficit/hyperactivity disorder
(Doctoral thesis, 2020-06-19)Background: Attention-deficit/hyperactivity disorder (ADHD) comprises cognitive and behavioural traits present from childhood. During lifespan, people with ADHD are more prone to develop psychiatric- and somatic comorbidities ...