Blar i Department of Biomedicine på dokumenttype "Doctoral thesis"
Viser treff 41-60 av 61
-
Phospholipase D in human blood platelets
(Doctoral thesis, 2008-05-30)We have studied phospholipase D (PLD) in human blood platelets. This enzyme hydrolyzes phosphatidylcholine to phosphatidic acid (PA) and choline, where PA is considered to be the main effector of PLDs function in cells. ... -
Regulatory post-translational modifications and protein-protein interactions involved in function and proteostasis of aromatic amino acid hydroxylases
(Doctoral thesis, 2021-09-16)The non-heme iron and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) dependent aromatic amino acid hydroxylases (AAAHs) family of enzymes include phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), and tryptophan ... -
The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
(Doctoral thesis, 2016-05-09)Aging is the critical risk factor for many forms of cancer. We used the mammary gland as a model system to study the impact of age on human epithelia in which age is the greatest risk factor for cancer. Dysfunctional ... -
Role of gingival lymphatics in tissue fluid balance and periodontal disease development
(Doctoral thesis, 2012-05-25)Background: The gingiva is frequently challenged to oral bacteria which are able to induce inflammatory responses with increased fluid filtration and edema formation in the tissue. Under given circumstances periodontal ... -
Role of integrin α11β1 in breast cancer
(Doctoral thesis, 2021-09-24)Breast cancer cells are strongly influenced by a complex tumor microenvironment comprised of a diversity of stromal cells, including a heterogeneous population of cancer associated fibroblasts (CAFs), in addition to the ... -
The Roles of EXT-Like Proteins in Heparan Sulphate Biosynthesis
(Doctoral thesis, 2011-02-11)Heparan sulphate (HS) proteoglycans, composed of a core protein and one or more negatively charged HS chains, are a major component of extracellular matrices and are located on the plasma membrane of all animal cells. The ... -
Semaphorin 3A and Class 4 Semaphorins in Tooth Innervation and Development
(Doctoral thesis, 2014-10-10)Background: Dental trigeminal axon elongation, navigation and patterning occur in a controlled manner that is intimately linked to tooth shape formation and cell differentiation. Development of tooth results from sequential ... -
Structural and biochemical characterization of Malaria parasites
(Doctoral thesis, 2021-09-17)The Apicomplexa phylum includes more than 6000 species, and some of them are pathogens of humans and animals of socio-economic importance. The most representative parasites are Plasmodium spp. and Toxoplasma gondii. ... -
Structure-based Druggability Predictions of RNA Binding Sites and Design of RNA Ligands
(Doctoral thesis, 2022-09-15)Den post-antibotiske æraen truer og for å møte denne krisen trengs det tilgang til nye klasser av antibiotika. Ribvoswitcher er cis-genregulerende foldete strukturer av ikke-kodende RNA, som handler gjennom konformasjonsendringer ... -
Studies of α11β1 integrin in the mouse and human periodontal ligament
(Doctoral thesis, 2009-06-12) -
Studies on viral gene transfer and angiogenesis inhibition in experimental glioma models
(Doctoral thesis, 2006-11-03) -
Study of the role of skin lymphatics in electrolyte and blood pressure regulation
(Doctoral thesis, 2020-02-21)Cardiovascular diseases are the major cause of death worldwide and represent a dramatic socio-economic challenge. Hypertension accounts for 18% of cardiovascular disease deaths in the Western countries, and is a major risk ... -
A study on features and markers of cellular metabolic rewiring
(Doctoral thesis, 2019-02-15)Mammalian cells regulate energy metabolism through molecular responses linked to the microenvironment and nutrient supply. Context dependent abnormalities of energy metabolism are important in disorders such as cancer, ... -
A study on metabolic rewiring in cancer cell plasticity
(Doctoral thesis, 2020-08-21)Adaptation of cellular energetics is an important feature of tumorigenesis as a vast supply of nutrients is needed to accommodate increased growth. Essential energy pathways includes glucose, fatty acid and amino acid ... -
Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
(Doctoral thesis, 2013-06-19)Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. The patients’ median survival is only 14.6 months despite multimodal treatment, including surgery and concomitant radiation and chemotherapy. ... -
Translational regulation in the adult brain: mediated by BDNF signalling, stress, and chronic antidepressant treatment
(Doctoral thesis, 2010-09-01)One of the most amazing features of the brain is its plasticity. This is a fundamental process by which the brain acquires information and makes the appropriate adaptive changes, a process that makes us able to think, feel, ... -
Tumor oxygenation - influence on mammary tumor growth, progression and response to chemotherapy
(Doctoral thesis, 2011-04-28) -
Understanding proteostasis dysregulation in phenylketonuria – a paradigm disease for inborn error of metabolism
(Doctoral thesis, 2022-09-06)Fenylketonuria (PKU) er en medfødt stoffskiftesykdom forårsaket av mutasjoner i genet for fenylalanin hydroksylase (PAH), og fører til ustabile og ofte feilfoldete enzymer med nedsatt evne til å metabolisere aminosyren ... -
Using mass spectrometry-based proteomics to improve the understanding of multiple sclerosis treatments
(Doctoral thesis, 2021-06-23)In this work, the effects of multiple sclerosis (MScl) treatments were investigated by quantitative proteomics. First, the effects of the anti-inflammatory drug Fingolimod was studied to see if the drug affected central ... -
Vascular endothelial growth factors and receptors - from normal dental pulp to apical pathology
(Doctoral thesis, 2016-02-12)The VEGFs -A, -B, -C, -D are important signaling molecules with pivotal implication in the growth of blood and lymphatic vessels, the so-called angio- and lymphangiogenesis. They exert their activities by binding to their ...