Browsing Department of Biomedicine by Journals "Science Advances"
Now showing items 1-3 of 3
-
GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
(Journal article; Peer reviewed, 2020)Carnosine and related β-alanine–containing peptides are believed to be important antioxidants, pH buffers, and neuromodulators. However, their biosynthetic routes and therapeutic potential are still being debated. This ... -
Mechanism of actin N-terminal acetylation
(Journal article; Peer reviewed, 2020)About 80% of human proteins are amino-terminally acetylated (Nt-acetylated) by one of seven Nt-acetyltransferases (NATs). Actin, the most abundant protein in the cytoplasm, has its own dedicated NAT, NAA80, which acts ... -
PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities
(Journal article; Peer reviewed, 2023)PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription, and DNA replication stress management. However, little is known about the ADP-ribosylation activity of PARP14, including its ...