Blar i Department of Biomedicine på tidsskrift "Scientific Reports"
Viser treff 1-16 av 16
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Apicomplexan actin polymerization depends on nucleation
(Peer reviewed; Journal article, 2017-09-22)Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ... -
Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis
(Journal article; Peer reviewed, 2021-02-18)Despite intensive research, the aetiology of multiple sclerosis (MS) remains unknown. Cerebrospinal fluid proteomics has the potential to reveal mechanisms of MS pathogenesis, but analyses must account for disease ... -
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Peer reviewed; Journal article, 2017-10-24)Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ... -
A cross-species whole genome siRNA screen in suspension-cultured Chinese hamster ovary cells identifies novel engineering targets
(Peer reviewed; Journal article, 2019-06-18)High-throughput siRNA screens were only recently applied to cell factories to identify novel engineering targets which are able to boost cells towards desired phenotypes. While siRNA libraries exist for model organisms ... -
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis
(Journal article; Peer reviewed, 2021)Two pathophysiological different experimental models for multiple sclerosis were analyzed in parallel using quantitative proteomics in attempts to discover protein alterations applicable as diagnostic-, prognostic-, or ... -
Dynamic switching between intrinsic and extrinsic mode networks as demands change from passive to active processing
(Journal article; Peer reviewed, 2020-12-08)In this study we report on the relationship between default and extrinsic mode networks across alternating brief periods of rest and active task processing. Three different visual tasks were used in a classic fMRI ON–OFF ... -
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
(Peer reviewed; Journal article, 2017)Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1−/− mice, but not Epac2−/− mice, have prolonged bleeding time, ... -
Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays
(Journal article; Peer reviewed, 2020)3D cell culture assays are becoming increasingly popular due to their higher resemblance to tissue environment. These provide an increased complexity compared to the growth on 2D surface and therefore allow studies of ... -
Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury
(Journal article; Peer reviewed, 2020)FRMD6, a member of the group of FERM-domain proteins, is involved both in communication between cells, interactions with extracellular matrix, cellular apoptotic and regenerative mechanisms. FRMD6 was first discovered in ... -
Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation
(Peer reviewed; Journal article, 2019)Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both ... -
Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line
(Peer reviewed; Journal article, 2017-07-10)Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between two cytoplasmic leaflets ... -
Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells
(Journal article; Peer reviewed, 2021)Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized and poorly understood area of cancer therapy. Metformin, a ... -
Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy
(Peer reviewed; Journal article, 2019-09-24)The exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2) are expressed in a cell specific manner in the liver, but their biological functions in this tissue are poorly understood. The current study was ... -
Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
(Journal article; Peer reviewed, 2021)All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ... -
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
(Peer reviewed; Journal article, 2016-07-27)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ... -
Tumor-penetrating peptide for systemic targeting of Tenascin-C
(Journal article; Peer reviewed, 2020)Extracellular matrix in solid tumors has emerged as a specific, stable, and abundant target for affinity-guided delivery of anticancer drugs. Here we describe the homing peptide that interacts with the C-isoform of Tenascin-C ...