Department of Biomedicine: Recent submissions

Now showing items 141-160 of 710

    • Current landscape and future perspectives in preclinical MR and PET imaging of brain metastasis 

      Aasen, Synnøve Nymark; Espedal, Heidi; Keunen, Olivier; Adamsen, Tom Christian Holm; Bjerkvig, Rolf; Thorsen, Frits (Journal article; Peer reviewed, 2021)
      Brain metastasis (BM) is a major cause of cancer patient morbidity. Clinical magnetic resonance imaging (MRI) and positron emission tomography (PET) represent important resources to assess tumor progression and treatment ...

    • Synthetic corticosteroids as tryptophan hydroxylase stabilizers 

      Betari, Nibal; Teigen, Knut; Sahlholm, Kristoffer; Haavik, Jan (Journal article; Peer reviewed, 2021)
      Background: Clinically, corticosteroids are used mainly for their immune-modulatory properties but are also known to influence mood. Despite evidence of a role in regulating tryptophan hydroxylases (TPH), key enzymes in ...

    • Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin 

      Hunter, Emma J; Hamaia, Samir W.; Gullberg, Elon Donald; Malcor, Jean-Daniel; Farndale, Richard W. (Journal article; Peer reviewed, 2021)
      Integrins are a family of 24 adhesion receptors which are both widely-expressed and important in many pathophysiological cellular processes, from embryonic development to cancer metastasis. Hence, integrin inhibitors are ...

    • Collagen Assembly at the Cell Surface: Dogmas Revisited 

      Musiime, Moses; Chang, Joan; Hansen, Uwe; Kadler, Karl E.; Zeltz, Cedric; Gullberg, Elon Donald (Journal article; Peer reviewed, 2021)
      With the increased awareness about the importance of the composition, organization, and stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to understand the details of how cells ...

    • ADP-ribosyltransferases, an update on function and nomenclature 

      Lüscher, Bernhard; Ahel, I; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter; Chang, Paul; Cohen, Michael S.; Corda, Daniela; Dantzer, F.; Daugherty, MD; Dawson, TM; Dawson, VL; Deindl, S; Fehr, AR; Feijs, KLH; Filippov, DV; Gagné, JP; Grimaldi, Giulia; Guettler, S; Hoch, NC; Hottiger, MO; Korn, P; Kraus, WL; Ladurner, Andreas G.; Lehtiö, Lari; Leung, AKL; Lord, CJ; Mangerich, A; Matic, Ivan; Matthews, Jason; Moldovan, George-Lucian; Moss, Joel; Natoli, Gioacchino; Nielsen, Michael L.; Niepel, Mario; Nolte, Friedrich; Pascal, John; Paschal, Bryce M; Pawłowski, Krzysztof; Poirier, Guy G; Smith, Susan; Timinszky, Gyula; Wang, Zhao-Qi; Yélamos, José; Xiaochun, Yu; Zaja, Roko; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in intra- ...

    • Human blood serum proteome changes after 6 hours of sleep deprivation at night 

      Bjørkum, Alvhild Alette; Duran, Ana Carasco; Berven, Frode Steingrimsen; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Peer reviewed, 2021)
      Background The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories ...

    • Mechanistic Insight and Translational Possibilities of Obesity-Breast Cancer Connection 

      Liu, Xiaozheng (Doctoral thesis, 2021-12-07)
      Obesity is an independent risk factor for more than thirteen cancer types. In breast cancer context, obesity is strongly associated with higher incidence and poorer prognosis in postmenopausal patients. The management of ...

    • C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer 

      Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung; Pedersen, Line; Lepland, Johanna; Takle, Sina Thorsen; Madeleine, Noëlly; Peters, Stacey D'mello; Wogsland, Cara Ellen; Grøndal, Sturla Magnus; Lorens, James Bradley; Goodarzi, Hani; Lønning, Per Eystein; Knappskog, Stian; Molven, Anders; Halberg, Nils Henrik (Journal article; Peer reviewed, 2022)
      Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal breast cancer. Moreover, it is known that obesity promotes stem cell-like properties of breast cancer ...

    • High-dimensional immunotyping of tumors grown in obese and non-obese mice 

      Wogsland, Cara Ellen; Lien, Hilde Eide; Pedersen, Line; Hanjra, Pahul; Grøndal, Sturla Magnus; Brekken, Rolf A; Lorens, James Bradley; Halberg, Nils Henrik (Journal article; Peer reviewed, 2021)
      Obesity is a disease characterized by chronic low-grade systemic inflammation and has been causally linked to the development of 13 cancer types. Several studies have been undertaken to determine whether tumors evolving ...

    • Diet, Physical Activity, and Disinhibition in Middle-Aged and Older Adults: A UK Biobank Study 

      Schweren, Lizanne J.S.; van Rooij, Daan; Shi, Huiqing; Larsson, Henrik; Arias-Vasquez, Alejandro; Li, Lin; Kvalvik, Liv Grimstvedt; Haavik, Jan; Buitelaar, Jan; Hartman, Catharina (Journal article; Peer reviewed, 2021)
      Disinhibition is a prominent feature of multiple psychiatric disorders, and has been associated with poor long-term somatic outcomes. Modifiable lifestyle factors including diet and moderate-to-vigorous physical activity ...

    • Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants 

      Uusitalo, Maiju; Klenow, Martin Berg; Laulumaa, Saara; Blakeley, Matthew P.; Simonsen, Adam Cohen; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2021)
      Peripheral myelin protein 2 (P2) is a fatty acid-binding protein expressed in vertebrate peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of P2 include membrane stacking and lipid ...

    • Temporal variations in the nutrient content of Norwegian farmed Atlantic salmon (Salmo salar), 2005–2020 

      Reksten, Amalie Moxness; Ho, Quang Tri; Nøstbakken, Ole Jakob; Markhus, Maria Wik; Kjellevold, Marian; Bøkevoll, Annbjørg; Hannisdal, Rita; Frøyland, Livar; Madsen, Lise; Dahl, Lisbeth (Journal article; Peer reviewed, 2022)
      The changes in the feed of farmed Atlantic salmon (Salmo salar) towards a more plant-based diet affect the nutritional value of the fillets. By compiling the contents of a range of nutrients in 1108 samples of Norwegian ...

    • The balance between NAD+ biosynthesis and consumption in ageing 

      Strømland, Øyvind; Diab, Joseph; Ferrario, Eugenio; Sverkeli, Lars Jansen; Ziegler, Mathias (Journal article; Peer reviewed, 2021)
      Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme in redox reactions. NAD+ is also important in cellular signalling as it is consumed by PARPs, SARM1, sirtuins and CD38. Cellular NAD+ levels regulate several ...

    • Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease 

      Khramova, Alina; Boi, Roberto; Fridén, Vincent; Granqvist, Anna Björnson; Nilsson, Ulf; Tenstad, Olav; Oveland, Eystein; Haraldsson, Börje; Ebefors, Kerstin; Nyström, Jenny (Journal article; Peer reviewed, 2021)
      All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ...

    • XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase 

      Sharma, Abhishek; Erasimus, Hélène; Pinto, Lia; Caron, Marie-Christine; Gopaul, Diyavarshini; Peterlini, Thibault; Neumann, Katrin; Nazarov, Petr V.; Fritah, Sabrina; Klink, Barbara; Herold-Mende, Christel C.; Niclou, Simone Pierrette; Pasero, Philippe; Calsou, Patrick; Masson, Jean-Yves; Britton, Sébastien; Van Dyck, Eric (Journal article; Peer reviewed, 2021)
      Replication-associated single-ended DNA double-strand breaks (seDSBs) are repaired predominantly through RAD51-mediated homologous recombination (HR). Removal of the non-homologous end-joining (NHEJ) factor Ku from resected ...

    • Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach 

      Dublang, Leire; Underhaug, Jarl; Flydal, Marte Innselset; Velasco-Carneros, Lorea; Maréchal, Jean-Didier; Moro, Fernando; Boyano, Maria Dolores; Martinez, Aurora; Muga, Arturo (Journal article; Peer reviewed, 2021)
      Heat shock protein (Hsp) synthesis is upregulated in a wide range of cancers to provide the appropriate environment for tumor progression. The Hsp110 and Hsp70 families have been associated to cancer cell survival and ...

    • Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat 

      Mullins, Linda; Ivy, Jessica; Ward, Mairi; Tenstad, Olav; Wiig, Helge; Kitada, Kento; Manning, Jon; Rakova, Natalia; Müller, Dominik; Mullins, John (Journal article; Peer reviewed, 2021)
      We discovered high Na+ and water content in the skin of newborn Sprague–Dawley rats, which reduced ~ 2.5-fold by 7 days of age, indicating rapid changes in extracellular volume (ECV). Equivalent changes in ECV post birth ...

    • Glioblastomas with primitive neuronal component harbor a distinct methylation and copy‑number profle with inactivation of TP53, PTEN, and RB1 

      Suwala, Abigail K.; Stichel, Damian; Schrimpf, Daniel; Maas, Sybren L. N.; Sill, Martin; Dohmen, Hildegard; Banan, Rouzbeh; Reinhardt, Annekathrin; Sievers, Philipp; Hinz, Felix; Blattner-Johnson, Mirjam; Hartmann, Christian; Schweizer, Leonille; Boldt, Henning B.; Kristensen, Bjarne Winther; Schittenhelm, Jens; Wood, Matthew D.; Chotar, Guillaume; Bjerkvig, Rolf; Das, Anirban; Tabori, Uri; Hasselblatt, Martin; Korshunov, Andrey; Abdullaev, Zied; Quezado, Martha; Aldape, Kenneth; Harter, Patrick N.; Snuderl, Matija; Hench, Jürgen; Frank, Stephan; Acker, Till; Brandner, Sebastian; Winkler, Frank; Wesseling, Pieter; Pfister, Stefan M.; Reuss, David E.; Wick, Wolfgang; von Deimling, Andreas; Jones, David T. W.; Sahm, Felix (Journal article; Peer reviewed, 2021)
      Glioblastoma IDH-wildtype presents with a wide histological spectrum. Some features are so distinctive that they are considered as separate histological variants or patterns for the purpose of classification. However, these ...

    • Elevated body weight modulates subcortical volume change and associated clinical response following electroconvulsive therapy 

      Opel, Nils; Narr, Katherine L; Abbott, Christopher; Argyelan, Miklos; Espinoza, Randall; Emsell, Louise; Bouckaert, Filip; Sienaert, Pascal; Vandenbulcke, Mathieu; Nordanskog, Pia; Repple, Jonathan; Kavakbasi, Erhan; Jorgensen, Martin B.; Paulson, Olaf B.; Hanson, Lars G.; Dols, Annemieke; van Exel, Eric; Oudega, Mardien L.; Takamiya, Akihiro; Kishimoto, Taishiro; Ousdal, Olga Therese; Haavik, Jan; Hammar, Åsa Karin; Ødegaard, Ketil Joachim; Kessler, Ute; Bartsch, Hauke; Dale, Anders M.; Baune, Bernhard T; Dannlowski, Udo; Oltedal, Leif; Redlich, Ronny (Journal article; Peer reviewed, 2021)
      Background: Obesity is a frequent somatic comorbidity of major depression, and it has been associated with worse clinical outcomes and brain structural abnormalities. Converging evidence suggests that electroconvulsive ...

    • Challenges and Prospects for Designer T and NK Cells in Glioblastoma Immunotherapy 

      Arnesen, Victoria Smith; Gras Navarro, Andrea; Enger, Martha (Journal article; Peer reviewed, 2021)
      Glioblastoma (GBM) is the most prevalent, aggressive primary brain tumour with a dismal prognosis. Treatment at diagnosis has limited efficacy and there is no standardised treatment at recurrence. New, personalised treatment ...