Department of Biomedicine: Recent submissions
Now showing items 461-480 of 710
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Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy
(Peer reviewed; Journal article, 2016-01)Background and aims: Peripheral neuropathic pain is described as a pain state caused by an injury or dysfunction of the nervous system, and could have clinical manifestations such as hyperalgesia, allodynia and spontaneous ... -
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
(Peer reviewed; Journal article, 2017-02)Aim: Maintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine ... -
Androgen receptor as potential therapeutic target in metastatic endometrial cancer
(Peer reviewed; Journal article, 2016-06-30)Purpose: The expression and involvement of estrogen (ER) and progesterone receptor (PR) is extensively studied in endometrial cancer. Androgen receptor (AR) is a hormone receptor less studied in female cancers, and we here ... -
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
(Peer reviewed; Journal article, 2016-07-27)Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural, and regulatory levels, and the preparation of ... -
Online interactive analysis of protein structure ensembles with Bio3D-web
(Peer reviewed; Journal article, 2016-11)Bio3D-web is an online application for analyzing the sequence, structure and conformational heterogeneity of protein families. Major functionality is provided for identifying protein structure sets for analysis, their ... -
Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling
(Peer reviewed; Journal article, 2016-11-28)Background: Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This ... -
Effects of dietary Lactobacillus plantarum and AHL lactonase on the control of Aeromonas hydrophila infection in tilapia
(Peer reviewed; Journal article, 2016-08)This study addressed the effects of dietary Lactobacillus plantarum or/and N-acylated homoserine lactonase (AHL lactonase) on controlling Aeromonas hydrophila infection in juvenile hybrid tilapia (Oreochromis niloticus♀ × ... -
AII amacrine cells: quantitative reconstruction and morphometric analysis of electrophysiologically identified cells in live rat retinal slices imaged with multi-photon excitation microscopy
(Peer reviewed; Journal article, 2016-02)AII amacrine cells have been found in all mammalian retinas examined and play an important role for visual processing under both scotopic and photopic conditions. Whereas ultrastructural investigations have provided a ... -
Stromal integrin α11β1 affects RM11 prostate and 4T1 breast xenograft tumors differently
(Peer reviewed; Journal article, 2016-03-18)Purpose It has been implied that the collagen binding integrin α11β1 plays a role in carcinogenesis. As still relatively little is known about how the stromal integrin α11β1 affects different aspects of tumor development, ... -
The effect of stromal integrin β3-deficiency on two different tumors in mice
(Peer reviewed; Journal article, 2016-01-12) -
A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study
(Peer reviewed; Journal article, 2016-08)Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate ... -
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins
(Peer reviewed; Journal article, 2016-05)Tyrosine hydroxylase (TH) is regulated by members of the 14-3-3 protein family. However, knowledge about the variation between 14-3-3 proteins in their regulation of TH is still limited. We examined the binding, effects ... -
BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis
(Peer reviewed; Journal article, 2016-02-18)Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology. Brain-derived neurotrophic factor (BDNF) represents a major player in ... -
Matrix metalloproteinase-2 knockout and heterozygote mice are protected from hydronephrosis and kidney fibrosis after unilateral ureteral obstruction
(Peer reviewed; Journal article, 2015-12-16)Matrix Metalloproteinase-2 (Mmp2) is a collagenase known to be important in the development of renal fibrosis. In unilateral ureteral obstruction (UUO) the obstructed kidney (OK) develops fibrosis, while the contralateral ... -
Targeting the AKT Pathway in Glioblastoma Multiforme
(Master thesis, 2016-06-01)In this study, the therapeutic efficacy of AKT allosteric and ATP competitive inhibitors was investigated in EGFR-amplified SKMG-3 and EGFR-low U-87 cell lines. The IC50 values of AKT inhibitors were determined by cellular ... -
In vitro and in vivo studies of a novel blood brain barrier permeabilizing peptide K16ApoE
(Master thesis, 2016-05-30)Brain metastasis is a common and severe complication arising in up to 40 % of cancer patients. The prognoses for patients with brain metastases are dismal, with a median treated survival of around 10 months. Treatment of ... -
Human tyrosine hydroxylase: Oxygen dependence and role in Dopa responsive dystonia
(Doctoral thesis, 2016-10-07)The aromatic amino acid hydroxylases (AAHs); phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), tryptophan hydroxylase 1 and 2 (TPH 1/TPH 2); are structurally and functionally related enzymes. All AAHs require ... -
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models
(Peer reviewed; Journal article, 2016-08-19)Background: Glioblastomas (GBMs) are highly malignant brain tumours with a poor prognosis, and current cytotoxic regimens provide only a limited survival benefit. The PI3K/Akt/mTOR pathway has been an attractive target for ... -
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control study
(Peer reviewed; Journal article, 2015-11-05)Background: The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several ... -
The effect of hyperbaric oxygen treatment on malignant progression in different breast cancer models in vivo
(Master thesis, 2016-07-01)Background: Hypoxia is an important feature of most solid tumors and has shown to serve as a mediator for aggressive tumor growth and malignant progression of cancer. A correlation between low oxygen tension in tumors and ...