Department of Biomedicine: Recent submissions
Now showing items 581-600 of 710
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Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways
(Peer reviewed; Journal article, 2014-03-11)Background: Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear. ... -
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
(Peer reviewed; Journal article, 2013-01-25)Background: The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats. Methods: Cognition was assessed using the Aversive Light Stimulus Avoidance Test (ALSAT). ... -
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets
(Peer reviewed; Journal article, 2014-06-21)Background: The dose-response relationship is a fundamental pharmacological parameter necessary to determine therapeutic thresholds. Epi-allelic hypomorphic analysis using RNA interference (RNAi) can similarly correlate ... -
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
(Peer reviewed; Journal article, 2014-07-11)Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ... -
Occupational issues of adults with ADHD
(Peer reviewed; Journal article, 2013-02-17)Background: ADHD is a common neurodevelopmental disorder that persists into adulthood. Its symptoms cause impairments in a number of social domains, one of which is employment. We wish to produce a consensus statement on ... -
Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe
(Master thesis, 2014-06-05)The incidence of malignant melanoma has increased steadily during the last decades. Large portions of individuals with this particular skin cancer develop multiple brain metastases, which is associated with a particular ... -
Assessment of Image Quality of a PET/CT scanner for a Standarized Image situation Using a NEMA Body Phantom. “The impact of Different Image Reconstruction Parameters on Image quality”
(Master thesis, 2013-09-01)Radiologists and medical practitioners are working daily with images from integrated Positron Emission Tomography/ Computed Tomography (PET/CT) scanners in order to detect potentially lethal diseases. It is thus very ... -
Biological responses of dental pulp stem cells to surfaces modified by collagen 1 and fibronectin
(Master thesis, 2014-01-18)Collagen 1 and fibronectin are extracellular matrix proteins that contribute in cell activity and involve in regulating dental pulp stem cells. The purpose of this in vitro study was to investigate the effect of collagen ... -
Arc protein-protein interactions in long-term potentiation in the rat dentate gyrus in vivo
(Master thesis, 2014-06-02)Synaptic plasticity is the ability of neuronal synapses to change in strength over time, and is considered to be a foundation for learning and memory. Long-term potentiation (LTP) is a widely studied form of synaptic ... -
POU3f2 in human gliomas - Expression pattern and functional role
(Master thesis, 2014-06-02)Gliomas are tumors of the central nervous system (CNS). They are responsible for about 28% of all central nervous system tumors and for 80% of all malignant brain tumors. The most commonly used classification and grading ... -
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(Master thesis, 2012-11-05)Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ... -
Identification of Dynamic Changes in Proteins Associated with the Cellular Cytoskeleton after Exposure to Okadaic Acid
(Peer reviewed; Journal article, 2013)Exposure of cells to the diarrhetic shellfish poison, okadaic acid, leads to a dramatic reorganization of cytoskeletal architecture and loss of cell-cell contact. When cells are exposed to high concentrations of okadaic ... -
Effective polyethylene glycol passivation for the inhibition of surface interactions of peripheral blood mononuclear cells and platelets
(Peer reviewed; Journal article, 2013-06-20)The inhibition of unspecific adhesion of human white blood cells is a prerequisite for applications requiring the control of defined surface interactions. In this study, a passivation agent based on polyethylene glycol ... -
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival
(Peer reviewed; Journal article, 2013-09-09)Glioblastoma (GBM) is the most malignant brain tumor where patients’ survival is only 14.6 months, despite multimodal therapy with debulking surgery, concurrent chemotherapy and radiotherapy. There is an urgent, unmet need ... -
Targeting the anti-inflammatory interplay promoting glioblastoma progression with combined natural killer cells and mab9.2.27 against NG2/CSPG4. A novel strategy to reveal glioblastoma to the immune system
(Doctoral thesis, 2013-06-19)Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. The patients’ median survival is only 14.6 months despite multimodal treatment, including surgery and concomitant radiation and chemotherapy. ... -
Novel method for isolating untouched rat natural killer cells with higher purity compared with positive selection and fluorescenceactivated cell sorting
(Peer reviewed; Journal article, 2010-11)Natural killer (NK) cells are important effectors of both innate and adaptive immune responses. Although human and mouse NK cells are extensively characterized, much less is known about the rat cells, partly because of the ... -
Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen
(Peer reviewed; Journal article, 2013-07-11)Background: The tumour suppressor and transcription factor p53 is a major determinant of the therapeutic response to anthracyclines. In healthy tissue, p53 is also considered pivotal for side effects of anthracycline ... -
Melanoma brain metastatis. Animal models, detection and therapy interventions
(Doctoral thesis, 2013-12-11) -
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
(Peer reviewed; Journal article, 2013)We show that cyclic AMP (cAMP) elevating agents protect blasts from patients with acute promyelocytic leukemia (APL) against death induced by first-line anti-leukemic anthracyclines like daunorubicin (DNR). The cAMP effect ... -
Abrogation of Anthracycline and Ischemia-Reperfusion Induced Injury by Cell Signaling Modulators
(Doctoral thesis, 2013-10-18)Chemotherapy has a long history in cancer treatment, and the anthracycline used in Paper I and II are among the most effective anti-cancer drugs developed. Unfortunately, the use of anthracyclines is dose-restricted due ...