Department of Biomedicine: Recent submissions
Now showing items 621-640 of 710
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Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells
(Peer reviewed; Journal article, 2012-03-27)Human mesenchymal stem cells are primary multipotent cells capable of differentiating into several cell types including adipocytes when cultured under defined in vitro conditions. In the present study we investigated the ... -
Increased Fibrosis and Interstitial Fluid Pressure in Two Different Types of Syngeneic Murine Carcinoma Grown in Integrin β3-Subunit Deficient Mice
(Peer reviewed; Journal article, 2012-03-30)Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that αVβ3 expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), ... -
Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes
(Peer reviewed; Journal article, 2012-03-22)Background: Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of ... -
Effect of Topical Anaesthetics on Interstitial Colloid Osmotic Pressure in Human Subcutaneous Tissue Sampled by Wick Technique
(Peer reviewed; Journal article, 2012-02-14)Objectives: To measure colloid osmotic pressure in interstitial fluid (COPi) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. ... -
Differential expression patterns of conserved miRNAs and isomiRs during Atlantic halibut development
(Peer reviewed; Journal article, 2012-01-10)Background: MicroRNAs (miRNAs) play a major role in animal ontogenesis. Size variants of miRNAs, isomiRs, are observed along with the main miRNA types, but their origin and possible biological role are uncovered yet. ... -
Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
(Peer reviewed; Journal article, 2012-01-17)Background The tumor microenvironment is pivotal in tumor progression. Thus, we aimed to develop a mammary tumor model to elucidate molecular characteristics in the stroma versus the tumor cell compartment by global gene ... -
Proteogenomic Analysis of Polymorphisms and Gene Annotation Divergences in Prokaryotes using a Clustered Mass Spectrometry-Friendly Database
(Peer reviewed; Journal article, 2011-01)Precise annotation of genes or open reading frames is still a difficult task that results in divergence even for data generated from the same genomic sequence. This has an impact in further proteomic studies, and also ... -
Cellular responses to metabolic stress. A study on the role of mitochondria in the crosstalk between cell metabolism and survival signaling
(Doctoral thesis, 2012-08-31)Metabolic imbalance is associated with increased risk of several diseases, including cancer. Metabolism affects or is affected by virtually all other cellular processes, which is not surprising considering their conserved ... -
Effects of oil compounds and persistent organic pollutants (POPs) on phospholipid composition in liver and brain of Atlantic cod (Gadus morhua)
(Doctoral thesis, 2012-10-12)The work in this thesis is part of a project led by the Institute of Marine Research (IMR), with partners at the Department of Biomedicine (University of Bergen, UiB), the National Institute of Nutrition and Seafood Research ... -
Role of gingival lymphatics in tissue fluid balance and periodontal disease development
(Doctoral thesis, 2012-05-25)Background: The gingiva is frequently challenged to oral bacteria which are able to induce inflammatory responses with increased fluid filtration and edema formation in the tissue. Under given circumstances periodontal ... -
The effect of hyperbaric oxygen treatment, alone or in combination with 5-FU, on a MDA-MB-231 human mammary tumor model
(Master thesis, 2012-06-20)Background: Previous studies of hyperbaric oxygen (HBO) treatment on chemically induced and murine breast cancer models have shown promising results. This study was performed to elucidate the effects of HBO on a human ... -
Autoimmune Addison's Disease and DNA Methylation. Identification of Differentially Methylated Regions and Development of Methylation Specific PCR for Selected Genes
(Master thesis, 2012-07-01)Autoimmune Addison's Disease (AAD) is a classical organ-specific autoimmune disease (AID) that is characterized by autoreactivity towards the adrenal cortex, leading to insufficient production of steroid hormones and death ... -
Association between the number of CAG repeats in polymerase gamma and Parkinson disease in the Norwegian population
(Master thesis, 2012-06-01)Parkinson disease (PD) is a common neurodegenerative movement disorder that increases in prevalence with age. It is characterized clinically by resting tremor, rigidity, bradykinesia, and failing balance, and is due to the ... -
The role of autoantibodies in cell mediated autoimmune Addison`s disease
(Master thesis, 2012-05-31)Background: Addison`s disease (primary adrenal insufficiency) is a prototypic organ-specific autoimmune disease affecting the adrenal cortex. Autoimmune Addison`s disease (AAD) is often characterized by autoantibodies ... -
Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo
(Master thesis, 2012-05-30)Synaptic plasticity is defined as the ability of a neuronal synapse to change in strength, and is believed to be the basis of learning and memory. An example of synaptic plasticity, by far the most studied, is long-term ... -
Mass spectrometry-based proteomics of human cerebrospinal fluid. Biomarker discovery and verification in multiple sclerosis
(Master thesis, 2012-06-01)The main focus of this study was to use mass spectrometry-based proteomics to study protein abundance in cerebrospinal fluid (CSF) to reveal proteins that could serve as biomarker candidates in multiple sclerosis (MScl). ... -
Multi-national Gene Expression Profiling of Oral Squamous Cell Carcinomas. Biological Pathways Regardless of Differences Related to Life-style and Ethnicity
(Doctoral thesis, 2012-02-02)Oral squamous cell carcinoma (OSCC) is a major health problem in many developing countries, representing more than 25% of all new cancer cases in some countries such as India and Sri Lanka. Cigarette smoking, smokeless ... -
Development of an RNA Interference Tool, Characterization of Its Target, and an Ecological Test of Caste Differentiation in the Eusocial Wasp Polistes
(Peer reviewed; Journal article, 2011-11-01)Recent advancements in genomics provide new tools for evolutionary ecological research. The paper wasp genus Polistes is a model for social insect evolution and behavioral ecology. We developed RNA interference (RNAi)-mediated ... -
The Regulatory Subunit of PKA-I Remains Partially Structured and Undergoes b-Aggregation upon Thermal Denaturation
(Peer reviewed; Journal article, 2011-03-04)Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic ... -
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice
(Peer reviewed; Journal article, 2011-09-23)Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ...