Department of Biomedicine: Nye registreringer
Viser treff 361-380 av 710
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Introduction to opportunities and pitfalls in functional mass spectrometry based proteomics
(Peer reviewed; Journal article, 2014-01)With the advent of mass spectrometry based proteomics, the identification of thousands of proteins has become commonplace in biology nowadays. Increasingly, efforts have also been invested toward the detection and localization ... -
Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
(Peer reviewed; Journal article, 2019-04-10)Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across ... -
Practical considerations for omics experiments in biomedical sciences
(Peer reviewed; Journal article, 2016)Modern analytical techniques provide an unprecedented insight to biomedical samples, allowing an in depth characterization of cells or body fluids, to the level of genes, transcripts, peptides, proteins, metabolites, or ... -
Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors
(Master thesis, 2014-02-28)The thesis has the title Single cell analysis of signal transduction in hematopoietic stem and progenitor cells from healthy donors". Flow cytometry enables complex biochemical signaling networks to be determined in ... -
The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice
(Peer reviewed; Journal article, 2019-05-23)Low-fat diets and energy restriction are recommended to prevent obesity and to induce weight loss, but high-protein diets are popular alternatives. However, the importance of the protein source in obesity prevention and ... -
Sub-atomic resolution crystal structures reveal conserved geometric outliers at functional sites
(Peer reviewed; Journal article, 2019-08-22)Myelin protein 2 (P2) is a peripheral membrane protein of the vertebrate nervous system myelin sheath, having possible roles in both lipid transport and 3D molecular organization of the multilayered myelin membrane. We ... -
Exploring the potential of public proteomics data
(Peer reviewed; Journal article, 2016)In a global effort for scientific transparency, it has become feasible and good practice to share experimental data supporting novel findings. Consequently, the amount of publicly available MS‐based proteomics data has ... -
The effect of omega-3 and mega-6 polyunsaturated fatty acids on the production of cyclooxygenase and lipoxygenase metabolites by human umbilical vein endothelial cells
(Peer reviewed; Journal article, 2019-04-27)Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the ... -
Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation
(Peer reviewed; Journal article, 2019)Fatty acid oxidation is a central fueling pathway for mitochondrial ATP production. Regulation occurs through multiple nutrient- and energy-sensitive molecular mechanisms. We explored if upregulated mRNA expression of the ... -
The Role of Axl in Cancer and Stem Cell Plasticity: in vivo Lineage Tracing and Imaging Mass Cytometry Analysis
(Master thesis, 2019-11-14) -
EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology
(Peer reviewed; Journal article, 2019)Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research ... -
Capacitance measurement of dendritic exocytosis in an electrically coupled inhibitory retinal interneuron: an experimental and computational study
(Peer reviewed; Journal article, 2019-08-04)Exocytotic release of neurotransmitter can be quantified by electrophysiological recording from postsynaptic neurons. Alternatively, fusion of synaptic vesicles with the cell membrane can be measured as increased capacitance ... -
Work participation in ADHD and associations with social characteristics, education, lifetime depression, and ADHD symptom severity
(Peer reviewed; Journal article, 2019-06)The literature refers to high rates of occupational failure in the population of adults with ADHD. The explanation for this is less known. The aim of the present study was to examine associations between social characteristics ... -
Novel loci associated with attention-deficit/hyperactivity disorder are revealed by leveraging polygenic overlap with educational attainment
(Peer reviewed; Journal article, 2018-02)Objective Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable psychiatric condition. By exploiting the reported relationship between ADHD and educational attainment (EA), we aimed to improve ... -
Molecular structure and function of myelin protein P0 in membrane stacking
(Peer reviewed; Journal article, 2019)Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin ... -
The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach
(Doctoral thesis, 2019-04-12)Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively). Myelin insulates axons, which increases nerve conduction ... -
Crystallographic home-source X-ray data for the atomic-resolution experimental phasing of the Shank3 SH3 domain structure from pseudomerohedrally twinned crystals
(Peer reviewed; Journal article, 2018-10)By far most macromolecular crystallographic data collection and experimental phasing is nowadays carried out using synchrotron radiation. Here, we present two crystallographic datasets collected on a home-source X-ray ... -
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
(Peer reviewed; Journal article, 2018-06-25)Background: Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific ... -
Event-related-potential (ERP) correlates of performance monitoring in adults with attention-deficit hyperactivity disorder (ADHD)
(Peer reviewed; Journal article, 2018-04-11)Introduction: Attention-deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental disorders in children and tends to persist into adulthood. Evidence from neuropsychological, neuroimaging, and ... -
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
(Peer reviewed; Journal article, 2018-11-29)Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, ...