Department of Biomedicine: Nye registreringer
Viser treff 381-400 av 710
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The interstitium conducts extrarenal storage of sodium and represents a third compartment essential for extracellular volume and blood pressure homeostasis
(Peer reviewed; Journal article, 2018-03)The role of salt in the pathogenesis of arterial hypertension is not well understood. According to the current understanding, the central mechanism for blood pressure (BP) regulation relies on classical studies linking BP ... -
Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches
(Peer reviewed; Journal article, 2017-12)For most therapeutic antibodies, the interstitium is the target space. Although experimental methods for measuring antibody pharmacokinetics (PK) in this space are not well established, thus making quantitative assessment ... -
Electrotonic signal processing in AII amacrine cells: compartmental models and passive membrane properties for a gap junction-coupled retinal neuron
(Peer reviewed; Journal article, 2018-09)Amacrine cells are critical for processing of visual signals, but little is known about their electrotonic structure and passive membrane properties. AII amacrine cells are multifunctional interneurons in the mammalian ... -
A study on features and markers of cellular metabolic rewiring
(Doctoral thesis, 2019-02-15)Mammalian cells regulate energy metabolism through molecular responses linked to the microenvironment and nutrient supply. Context dependent abnormalities of energy metabolism are important in disorders such as cancer, ... -
Gender Differences in Psychiatric Comorbidity: Population-based study of 40,000 Adults with Attention-Deficit Hyperactivity Disorder
(Peer reviewed; Journal article, 2017-12-21)OBJECTIVE: We aimed at determining whether gender modified associations between ADHD and psychiatric comorbidities in adults. METHOD: We identified adults with ADHD by linking Norwegian national registries and compared ... -
An overview of deep learning in medical imaging focusing on MRI
(Peer reviewed; Journal article, 2018-12-13)What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started ... -
Nutritional properties of protein sources on diet-induced obesity, hepatic lipid accumulation, and fatty acid composition in mice
(Doctoral thesis, 2018-10-26)The prevalence of obesity has increased rapidly, and excess adiposity is associated with comorbidities that increase the risk of mortality. An energy-dense diet that is high in sugar and fat is one of the major explanations ... -
Effects of Frozen Storage on Phospholipid Content in Atlantic Cod Fillets and the Influence on Diet-Induced Obesity in Mice
(Peer reviewed; Journal article, 2018-05-30)A large fraction of the n-3 polyunsaturated fatty acids (PUFAs) in cod fillet is present in the form of phospholipids (PLs). Freezing initiates hydrolysis of the PLs present in the fillet. Here, we compared the effects of ... -
Characterization of the renal function in Epac1 (RapGef3) knockout mice
(Master thesis, 2014-06-03)The discovery of the exchange proteins directly activated by cAMP (Epac) has renewed our knowledge of intracellular cAMP signaling. The Epac1 isoform (RapGef3) shows high expression level in the kidney. In vitro studies ... -
The in vivo effect of integrin α11-deficiency and PDGFR inhibition in breast cancer
(Master thesis, 2018-10-19)Background: The tumor microenvironment is a major contributor to breast cancer progression. The abnormal composition of the extracellular matrix and its deregulated interactions with stromal cells, which is characterizing ... -
PKU mutation p.G46S prevents the stereospecific binding of l-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
(Peer reviewed; Journal article, 2017-02)Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric ... -
Structural similarities and functional differences clarify evolutionary relationships between tRNA healing enzymes and the myelin enzyme CNPase
(Peer reviewed; Journal article, 2017-05-16)Background: Eukaryotic tRNA splicing is an essential process in the transformation of a primary tRNA transcript into a mature functional tRNA molecule. 5′-phosphate ligation involves two steps: a healing reaction catalyzed ... -
Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma
(Peer reviewed; Journal article, 2017)Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy ... -
Apicomplexan actin polymerization depends on nucleation
(Peer reviewed; Journal article, 2017-09-22)Filamentous actin is critical for apicomplexan motility and host cell invasion. Yet, parasite actin filaments are short and unstable. Their kinetic characterization has been hampered by the lack of robust quantitative ... -
EXT proteins: Role in heparan sulfate Assembly and in Tumor biology
(Doctoral thesis, 2018-08-24)The exostosin family of proteins is necessary for heparan sulfate biosynthesis. Heparan sulfate polysaccharide biosynthesis is one of several different forms of proteinglycosylation processes that take place in the Golgi ... -
Arc interacts with the integral endoplasmic reticulum protein, calnexin
(Peer reviewed; Journal article, 2017-09-20)Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum ... -
Associations between attention-deficit/hyperactivity disorder and autoimmune diseases are modified by sex: a population-based cross-sectional study
(Peer reviewed; Journal article, 2018-05)Several studies have demonstrated associations between neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD), and the immune system, including autoimmune diseases. Since ADHD and many autoimmune ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Investigation of protein signalling pathways activated by sonoporation in cancer
(Master thesis, 2018-06-29)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ...