Department of Biomedicine: Nye registreringer

Viser treff 61-80 av 709

    • Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation 

      Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset; Santiago, Cesar; Kråkenes, Trond-André; Kleppe, Rune; Jose R, Lopez-Blanco; Marcilla, Miguel; Teigen, Knut; Alvira, Sara; Chacón, Pablo; Martinez, Aurora; Valpuesta, José M (Journal article; Peer reviewed, 2022)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and ...

    • A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation 

      Missaghian, Parisa; Dierker, Tabea; Khosrowabadi, Elham; Axling, Fredrik; Eriksson, Inger; Ghanem, Abdurrahman; Gullberg, Marion Kusche; Kellokumpu, Sakari; Kjellén, Lena (Journal article; Peer reviewed, 2022)
      NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 ...

    • Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition 

      Engelsen, Agnete Svendsen Tenfjord; Lotsberg, Maria Lie; Khouzam, Raefa Abou; Thiery, Jean Paul; Lorens, James; Chouaib, Salem; Terry, Stéphane (Journal article; Peer reviewed, 2022)
      The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical oncology have significantly improved the survival of a subset of cancer patients with metastatic disease previously considered uniformly ...

    • Upregulated integrin α11 in the stroma of cutaneous squamous cell carcinoma promotes skin carcinogenesis 

      Martínez-Nieto, Guillermo A.; Teppo, Hanna-Riikka; Petrelius, Noora; Izzi, Valerio; Devarajan, Raman; Petäistö, Tiina; Liu, Hengshuo; Kim, Kris S.; Karppinen, Sanna-Maria; Ruotsalainen, Heli; Koivunen, Jarkko; Mäki, Joni M.; Walker, Gilbert C.; Pihlajaniemi, Taina; Gullberg, Elon Donald; Heljasvaara, Ritva Leena (Journal article; Peer reviewed, 2022)
      Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated ...

    • Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97 

      Bothe, Sebastian; Hänzelmann, Petra; Böhler, Stephan; Kehrein, Josef; Zehe, Markus; Wiedemann, Christoph; Hellmich, Ute A.; Brenk, Ruth; Schindelin, Hermann; Sotriffer, Christoph (Journal article; Peer reviewed, 2022)
      Biosensor techniques have become increasingly important for fragment-based drug discovery during the last years. The AAA+ ATPase p97 is an essential protein with key roles in protein homeostasis and a possible target for ...

    • Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders 

      Fanelli, Giuseppe; Franke, Barbara; De Witte, Ward; Ruisch, I. Hyun; Haavik, Jan; van Gils, Veerle; Jansen, Willemijn J.; Vos, Stephanie J. B.; Lind, Lars; Buitelaar, Jan K.; Banaschewski, Tobias; Dalsgaard, Søren; Serretti, Alessandro; Mota, Nina Roth; Poelmans, Geert; Bralten, Janita (Journal article; Peer reviewed, 2022)
      The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer’s disease (AD), autism spectrum disorder (ASD), and obsessive-compulsive ...

    • Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker? 

      Zeltz, Cedric; Navab, Roya; Heljasvaara, Ritva Leena; Gullberg, Marion Kusche; Lu, Ning; Tsao, Ming-Sound; Gullberg, Elon Donald (Journal article; Peer reviewed, 2022)
      There is currently an increased interest in understanding the role of the tumor microenvironment (TME) in tumor growth and progression. In this context the role of integrins in cancer-associated fibroblasts (CAFs) will ...

    • Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics 

      Yadrykhinsky, Vladyslav; Georgiou, Charis; Brenk, Ruth (Journal article; Peer reviewed, 2022)
      Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of ...

    • The life cycle and enigmatic egress of coronaviruses 

      Prydz, Kristian; Saraste, Jaakko (Journal article; Peer reviewed, 2022)
      There has been considerable recent interest in the life cycle of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the causative agent of the Covid-19 pandemic. Practically every step in CoV replication—from ...

    • Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis 

      Guyon, Joris; Fernandez-Moncada, Ignacio; Larrieu, Claire M; Bouchez, Cyrielle L; Pagano Zottola, Antonio C; Galvis, Johanna; Chouleur, Tiffanie; Burban, Audrey; Joseph, Kevin; Ravi, Vidhya M; Espedal, Heidi; Røsland, Gro Vatne; Daher, Boutaina; Barre, Aurélien; Dartigues, Benjamin; Karkar, Slim; Rudewicz, Justine; Romero-Garmendia, Irati; Klink, Barbara; Grützmann, Konrad; Derieppe, Marie-Alix; Molinié, Thibaut; Obad, Nina; Léon, Céline; Seano, Giorgio; Miletic, Hrvoje; Heiland, Dieter Henrik; Marsicano, Giovanni; Nikolski, Macha; Bjerkvig, Rolf; Bikfalvi, Andreas; Daubon, Thomas (Journal article; Peer reviewed, 2022)
      Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, ...

    • High-affinity anti-Arc nanobodies provide tools for structural and functional studies 

      Markusson, Sigurbjörn; Hallin, Erik Ingmar; Bustad, Helene J.; Raasakka, Arne; Xu, Ju; Muruganandam, Gopinath; Loris, Remy; Martinez, Aurora; Bramham, Clive Raymond Evjen; Kursula, Petri (Journal article; Peer reviewed, 2022)
      Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals. However, the mechanistic ...

    • Activation-induced chromatin reorganization in neurons depends on HDAC1 activity 

      Grabowska, Agnieszka; Sas-Nowosielska, Hanna; Wojtas, Bartosz; Holm-Kaczmarek, Dagmara; Januszewicz, Elzbieta; Yushkevich, Yana; Czaban, Iwona; Trzaskoma, Pawel; Krawczyk, Katarzyna; Gielniewski, Bartlomiej; Martin-Gonzalez, Ana; Filipkowski, Robert Kuba; Olszynski, Krzysztof Hubert; Bernas, Tytus; Szczepankiewicz, Andrzej Antoni; Sliwinska, Malgorzata Alicja; Kanhema, Tambudzai; Bramham, Clive Raymond Evjen; Bokota, Grzegorz; Plewczynski, Dariusz; Wilczynski, Grzegorz Marek; Magalska, Adriana (Journal article; Peer reviewed, 2022)
      Spatial chromatin organization is crucial for transcriptional regulation and might be particularly important in neurons since they dramatically change their transcriptome in response to external stimuli. We show that ...

    • Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors 

      Knudsen, Arnon Møldrup; Halle, Bo; Cédile, Oriane; Burton, Mark; Baun, Christina; Thisgaard, Helge; Anand, Atul; Hubert, Christopher; Thomassen, Mads; Michaelsen, Signe Regner; Olsen, Birgitte Brinkmann; Dahlrot, Rikke Hedegaard; Bjerkvig, Rolf; Lathia, Justin Durla; Kristensen, Bjarne Winther (Journal article; Peer reviewed, 2022)
      Background Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical tumor resection is a cornerstone in glioblastoma therapy, but its ...

    • Tumor-associated macrophages in gliomas—basic insights and treatment opportunities 

      Andersen, Johannes Kaasa; Miletic, Hrvoje; Hossain, Md Jubayer al (Journal article; Peer reviewed, 2022)
      Glioma refers to a group of primary brain tumors which includes glioblastoma (GBM), astrocytoma and oligodendroglioma as major entities. Among these, GBM is the most frequent and most malignant one. The highly infiltrative ...

    • HIDEA syndrome is caused by biallelic, pathogenic, rare or founder P4HTM variants impacting the active site or the overall stability of the P4H-TM protein 

      Kraatari-Tiri, Minna; Soikkonen, Leila; Myllykoski, Matti Aukusti; Jamshidi, Yalda; Karimiani, Ehsan G.; Komulainen-Ebrahim, Jonna; Kallankari, Hanna; Mignot, Cyril; Depienne, Christel; Keren, Boris; Nougues, Marie-Christine; Alsahlawi, Zahra; Romito, Antonio; Martini, Javier; Toosi, Mehran B.; Carroll, Christopher J.; Tripolszki, Kornelia; Bauer, Peter; Uusimaa, Johanna; Bertoli-Avella, Aida M.; Koivunen, Peppi; Rahikkala, Elisa (Journal article; Peer reviewed, 2022)
      HIDEA syndrome is caused by biallelic pathogenic variants in P4HTM. The phenotype is characterized by muscular and central hypotonia, hypoventilation including obstructive and central sleep apneas, intellectual disability, ...

    • The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation 

      Malmgren, Linnea; Öberg, Carl; den Bakker, Emil; Leion, Felicia; Siódmiak, Joanna; Åkesson, Anna; Lindström, Veronica; Herou, Erik; Dardashti, Alain; Xhakollari, Liana; Grubb, Gabriel; Strevens, Helena; Abrahamson, Magnus; Helmersson-Karlqvist, Johanna; Magnusson, Martin; Björk, Jonas; Nyman, Ulf; Ärnlöv, Johan; Ridefeldt, Peter; Åkerfeldt, Torbjörn; Hansson, Magnus; Sjöström, Anna; Mårtensson, Johan; Itoh, Yoshihisa; Grubb, David; Tenstad, Olav; Hansson, Lars-Olov; Olafsson, Isleifur; Campos, Araceli Jarquin; Risch, Martin; Risch, Lorenz; Larsson, Anders; Nordin, Gunnar; Pottel, Hans; Christensson, Anders; Bjursten, Henrik; Bökenkamp, Arend; Grubb, Anders (Journal article; Peer reviewed, 2022)
      Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel ...

    • Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder: A cross-national cohort study of over 4.5 million individuals and their siblings in Finland, Norway, and Sweden 

      Hegvik, Tor-Arne; Klungsøyr, Kari; Kuja-Halkola, Ralf; Remes, Hanna; Haavik, Jan; D*Onofrio, Brian M.; Metsä-Simola, Niina; Engeland, Anders; Fazel, Seena; Lichtenstein, Paul; Martikainen, Pekka; Larsson, Henrik; Sariaslan, Amir (Journal article; Peer reviewed, 2023)
      Background A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder. Subsequent replication attempts have lacked sufficient power to confidently ...

    • Automated splitting into batches for observational biomedical studies with sequential processing 

      Burger, Bram; Vaudel, Marc; Barsnes, Harald (Journal article; Peer reviewed, 2022)
      Experimental design usually focuses on the setting where treatments and/or other aspects of interest can be manipulated. However, in observational biomedical studies with sequential processing, the set of available samples ...

    • Excitatory and inhibitory signaling in the rod pathway of the retina: Functional properties and activation of synaptic and extrasynaptic receptors 

      Beltrán Matas, Pablo (Doctoral thesis, 2021-01-29)
      The visual system is arguably one of the most complex and studied sensory systems. The processing of visual information starts in the retina, where photoreceptors transduce light stimuli (photons) to electrochemical signals ...

    • Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC 

      Van Damme, Petra; Osberg, Camilla; Jonckheere, Veronique; Glomnes, Nina; Gevaert, Kris; Arnesen, Thomas; Aksnes, Henriette (Journal article; Peer reviewed, 2022)
      N-terminal acetylation is a conserved protein modification among eukaryotes. The yeast Saccharomyces cerevisiae is a valuable model system for studying this modification. The bulk of protein N-terminal acetylation in S. ...