Department of Biomedicine: Nye registreringer

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    • Thiabendazole Inhibits Glioblastoma Cell Proliferation and Invasion Targeting Mini-chromosome Maintenance Protein 2 

      Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Feng, Zichao; Zhang, Yulin; Liu, Xiaofei; Li, Wenjie; Zhang, Qing; Chen, Anjing; Huang, Bin; Wang, Jian (Journal article; Peer reviewed, 2022)
      Thiabendazole (TBZ), approved by the US Food and Drug Administration (FDA) for human oral use, elicits a potential anticancer activity on cancer cells in vitro and in animal models. Here, we evaluated the efficacy of TBZ ...

    • Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention 

      Wang, Xu; Han, Mingzhi; Wang, Shuai; Sun, Yanfei; Zhao, Wenbo; Xue, Zhiyi; Liang, Xiangjun; Huang, Bin; Li, Gang; Chen, Anjing; Li, Xingang; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background: Splicing factors are essential for nascent pre-mRNA processing and critical in cancer progression, suggesting that proteins with splicing functions represent potential molecular targets for cancer therapy. Here, ...

    • Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells 

      Kropotov, Andrey; Kulikova, Veronika; Solovjeva, Ljudmila; Yakimov, Alexander; Nerinovski, Kirill; Svetlova, Maria; Sudnitsyna, Julia; Plusnina, Alena; Antipova, Maria; Khodorkovskiy, Mikhail; Migaud, Marie E.; Gambaryan, Stepan; Ziegler, Mathias; Nikiforov, Andrey (Journal article; Peer reviewed, 2022)
      Nicotinamide riboside (NR) is an effective precursor of nicotinamide adenine dinucleotide (NAD) in human and animal cells. NR supplementation can increase the level of NAD in various tissues and thereby improve physiological ...

    • Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma 

      Yabo, Yahaya A.; Niclou, Simone Pierrette; Golebiewska, Anna (Journal article; Peer reviewed, 2022)
      Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells display prominent intrinsic plasticity and ...

    • SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner 

      Zhang, Shouji; Zhao, Shulin; Qi, Yanhua; Li, Boyan; Wang, Huizhi; Pan, Ziwen; Xue, Hao; Jin, Chuandi; Qiu, Wei; Chen, Zihang; Guo, Qindong; Fan, Yang; Xu, Jianye; Gao, Zijie; Wang, Shaobo; Guo, Xing; Deng, Lin; Ni, Shilei; Xue, Fuzhong; Wang, Jian; Zhao, Rongrong; Li, Gang (Journal article; Peer reviewed, 2022)
      As one of the most common post-transcriptional modifications of mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect of RNA metabolism. Evidence indicates that dysregulation of m6A ...

    • Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma 

      Zhang, Xun; Yao, Zhong; Xue, Zhiyi; Wang, Shuai; Liu, Xuemeng; Hu, Yaotian; Zhang, Yan; Wang, Jian; Li, Xingang; Chen, Anjing (Journal article; Peer reviewed, 2022)
      Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying ...

    • Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development 

      Larrieu, Claire M.; Storevik, Simon Humberto; Guyon, Joris; Pagano Zottola, Antonio C.; Bouchez, Cyrielle L.; Derieppe, Marie-Alix; Tan, Tuan Zea; Miletic, Hrvoje; Lorens, James; Tronstad, Karl Johan; Daubon, Thomas; Røsland, Gro Vatne (Journal article; Peer reviewed, 2022)
      Glioblastoma (GB) are the most frequent brain cancers. Aggressive growth and limited treatment options induce a median survival of 12–15 months. In addition to highly proliferative and invasive properties, GB cells show ...

    • Human myelin proteolipid protein structure and lipid bilayer stacking 

      Ruskamo, Salla; Raasakka, Arne; Pedersen, Jan Skov; Martel, Anne; Škubník, Karel; Darwish, Tamim; Porcar, Lionel; Kursula, Petri (Journal article; Peer reviewed, 2022)
      The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of ...

    • Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone 

      Støve, Svein Isungset; Skjevik, Åge Aleksander; Teigen, Knut; Martinez, Aurora (Journal article; Peer reviewed, 2022)
      Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent neurotransmission. VMAT2 inhibitors are approved for symptomatic treatment ...

    • Structural insights into Charcot–Marie–Tooth disease-linked mutations in human GDAP1 

      Sutinen, Aleksi; Nguyen, Giang Thi Tuyet; Raasakka, Arne; Muruganandam, Gopinath; Loris, Remy; Ylikallio, Emil; Tyynismaa, Henna; Bartesaghi, Luca; Ruskamo, Salla; Kursula, Petri (Journal article; Peer reviewed, 2022)
      Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral polyneuropathy in humans, and its different subtypes are linked to mutations in dozens of different genes. Mutations in ganglioside-induced ...

    • Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis 

      Kong, Yang; Xue, Zhiwei; Wang, Haiying; Cui, Guangqiang; Chen, Anjing; Liu, Jie; Wang, Jian; Li, Xingang; Huang, Bin (Journal article; Peer reviewed, 2022)
      Rigorous molecular analysis of the immune cell environment and immune response of human tumors has led to immune checkpoint inhibitors as one of the most promising strategies for the treatment of human cancer. However, in ...

    • ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead 

      Misawa, Takuma; Wagner, Marek; Koyasu, Shigeo (Journal article; Peer reviewed, 2022)
      Group 2 innate lymphoid cells (ILC2s) were initially identified as a new type of lymphocytes that produce vigorous amounts of type 2 cytokines in adipose tissue. Subsequent studies revealed that ILC2s are present not only ...

    • Right ventricular postsystolic shortening: Resolution after opening a totally occluded right coronary artery 

      Saeed, Sahrai; Karaji, Iman; Skromme, Kaia; Øksnes, Anja; Larsen, Terje Hjalmar; Bleie, Øyvind (Journal article; Peer reviewed, 2022)
      Acute myocardial ischemia induces reduced systolic shortening and causes postsystolic shortening (PSS). Right ventricular (RV) PSS in coronary artery disease has been less studied. We present here the case of a 51-year-old ...

    • Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency 

      Pires-Afonso, Yolanda; Muller, Arnaud; Grzyb, Kamil; Oudin, Anaïs; Yabo, Yahaya A.; Sousa, Carole; Scafidi, Andrea; Poli, Aurélie; Cosma, Antonio; Halder, Rashi; Coowar, Djalil; Golebiewska, Anna; Skupin, Alexander; Niclou, Simone Pierrette; Michelucci, Alessandro (Journal article; Peer reviewed, 2022)
      In glioblastoma (GBM), tumour-associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising ...

    • TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein 

      Yang, Xu; Zhang, Yan; Xue, Zhiwei; Hu, Yaotian; Zhou, Wenjing; Xue, Zhiyi; Liu, Xuemeng; Liu, Guowei; Li, Wenjie; Liu, Xiaofei; Li, Xingang; Han, Mingzhi; Wang, Jian (Journal article; Peer reviewed, 2022)
      Background The tripartite motif (TRIM) family of proteins plays a key role in the developmental growth and therapeutic resistance of many tumors. However, the regulatory mechanisms and biological functions of TRIM proteins ...

    • The cooperative folding of annexin A2 relies on a transient nonnative intermediate 

      Hollås, Hanne; Ramirez, Juan; Nominé, Yves; Kostmann, Camille; Toto, Angelo; Gianni, Stefano; Travé, Gilles; Vedeler, Anni (Journal article; Peer reviewed, 2022)
      Annexins (Anxs) are a family of highly homologous proteins that bind and aggregate lipid vesicles in the presence of calcium. All members of the family contain a variable N-terminus determining specific functions, followed ...

    • Heparan sulfate dependent binding of plasmatic von Willebrand factor to blood circulating melanoma cells attenuates metastasis 

      Wang, Yuanyuan; Liu, Xiaobo; Obser, Tobias; Bauer, Alexander T.; Heyes, Martin; Starzonek, Sarah; Zulal, Mina; Opitz, Karena; Ott, Leonie; Riethdorf, Sabine; Lange, Tobias; Pantel, Klaus; Bendas, Gerd; Schneider, Stefan W.; Gullberg, Marion Kusche; Gorzelanny, Christian (Journal article; Peer reviewed, 2022)
      Heparan sulfate (HS), a highly negatively charged glycosaminoglycan, is ubiquitously present in all tissues and also exposed on the surface of mammalian cells. A plethora of molecules such as growth factors, cytokines or ...

    • Genome Guided Personalized Drug Therapy in Attention Deficit Hyperactivity Disorder 

      Haavik, Jan (Journal article; Peer reviewed, 2022)
      ADHD is a common behavioral syndrome with a heritability of 70–80%. Genome wide sequencing and association studies indicate that ADHD risk variants are distributed across a wide range of allele frequencies and relative ...

    • Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells 

      Ferreira, Tiago; Kulkarni, Amit; Bretscher, Clemens; Nazarov, Petr V.; Hossain, Md Jubayer al; Ystaas, Lars Andreas Rømo; Miletic, Hrvoje; Röth, Ralph; Niesler, Beate; Marchini, Antonio (Journal article; Peer reviewed, 2022)
      Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the ...

    • Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation 

      Bueno-Carrasco, María Teresa; Cuellar, Jorge; Flydal, Marte Innselset; Santiago, Cesar; Kråkenes, Trond-André; Kleppe, Rune; Jose R, Lopez-Blanco; Marcilla, Miguel; Teigen, Knut; Alvira, Sara; Chacón, Pablo; Martinez, Aurora; Valpuesta, José M (Journal article; Peer reviewed, 2022)
      Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines, and its dysfunction leads to DA deficiency and parkinsonisms. Inhibition by catecholamines and ...