Blar i Department of Clinical Medicine på tittel

Viser treff 1802-1821 av 2062

    • A simple versatile solution for collecting multidimensional clinical data based on the CakePHP web application framework 

      Biermann, Martin (Peer reviewed; Journal article, 2014-04)
      Clinical trials aiming for regulatory approval of a therapeutic agent must be conducted according to Good Clinical Practice (GCP). Clinical Data Management Systems (CDMS) are specialized software solutions geared toward ...

    • Simplifying the clinical classification of polymerase gamma (POLG) disease based on age of onset; studies using a cohort of 155 cases 

      Hikmat, Omar; Naess, Karin; Engvall, Martin; Klingenberg, Claus; Rasmussen, Magnhild; Tallaksen, Chantal; Brodtkorb, Eylert; Østergaard, Elsebet; de Coo, Irenaeus F.M.; Pias-Peleteiro, Leticia; Isohanni, Pirjo; Uusimaa, Johanna; Darin, Niklas; Rahman, Shamima; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      Background Variants in POLG are one of the most common causes of inherited mitochondrial disease. Phenotypic classification of POLG disease has evolved haphazardly making it complicated and difficult to implement in ...

    • Simulation-based team-training in acute stroke: Is it safe to speed up? 

      Høllesli, Liv Jorunn; Ajmi, Soffien Chadli; Kurz, Friedrich Martin Wilhelm; Tysland, Thomas Bailey; Hagir, Morten; Dalen, Ingvild; Qvindesland, Sigrun Anna; Ersdal, Hege Langli; Kurz, Kathinka Dæhli (Journal article; Peer reviewed, 2022)
      Background In acute ischemic stroke (AIS), rapid treatment with intravenous thrombolysis (IVT) is crucial for good clinical outcome. Weekly simulation-based team-training of the stroke treatment team was implemented, ...

    • Simultaneous bilateral aqueous misdirection following certolizumab therapy for rheumatoid arthritis 

      Hynnekleiv, Leif; Thrane, Alexander Stanley; Krohn, Jørgen (Journal article; Peer reviewed, 2020)
      Aqueous misdirection syndrome is a rare, incompletely understood, sight-threatening eye condition that is difficult to diagnose and treat. We present a case of simultaneous bilateral aqueous misdirection following the ...

    • Simultaneous Resection of Primary Colorectal Cancer and Synchronous Liver Metastases: Contemporary Practice, Evidence and Knowledge Gaps 

      Kleive, Dyre; Aas, Eline; Angelsen, Jon-Helge; Bringeland, Erling Audun; Nesbakken, Arild; Nymo, Linn Såve; Schultz, Johannes Kurt; Søreide, Kjetil; Yaqub, Sheraz (Journal article; Peer reviewed, 2021)
      The timing of surgical resection of synchronous liver metastases from colorectal cancer has been debated for decades. Several strategies have been proposed, but high-level evidence remains scarce. Simultaneous resection ...

    • Single use flexible ureteroscopes: Current status and future directions 

      Juliebø-Jones, Patrick; Ventimiglia, Eugenio; Somani, Bhaskar K.; Æsøy, Mathias S.; Gjengstø, Peder; Beisland, Christian; Ulvik, Øyvind (Journal article; Peer reviewed, 2023)
      Introduction: Single use ureteroscopes are a technological innovation that have become available in the past decade and gained increased popularity. To this end, there are now an increasing number of both benchside and ...

    • Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse 

      Taavitsainen, S.; Engedal, Nikolai; Cao, S.; Handle, Florian; Erickson, A.; Prekovic, Stefan; Wetterskog, D.; Tolonen, Teemu T.; Vuorinen, E.M.; Kiviaho, A.; Nätkin, R.; Häkkinen, T.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M.; Cremaschi, P.; Claessens, Frank; Visakorpi, Tapio; Tammela, T.L.J.; Murtola, T.; Granberg, K.J.; Lamb, Alastair D.; Ketola, Kirsi; Mills, Ian; Attard, Gerhardt; Wang, W.; Nykter, Matti; Urbanucci, Alfonso (Journal article; Peer reviewed, 2021)
      Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and ...

    • Six versus 2 weeks treatment with doxycycline in European Lyme neuroborreliosis: a multicentre, noninferiority, double-blinded, randomised and placebocontrolled trial 

      Solheim, Anne Marit; Lorentzen, Åslaug Rudjord; Dahlberg, Audun Olav; Flemmen, Heidi Øyen; Brune, Synne; Forselv, Kristine Johanne Nordstrøm; Pripp, Are Hugo; Bø, Margrete Halvorsen; Eikeland, Randi; Reiso, Harald; Mygland, Åse Daasvand; Ljøstad, Unn (Journal article; Peer reviewed, 2022)
      Background There is limited evidence regarding optimal duration of antibiotic treatment in neuroborreliosis. We aimed to compare efficacy and safety of oral doxycycline for 2 and 6 weeks in European Lyme neuroborreliosis ...

    • Six versus two weeks treatment with doxycycline in Lyme neuroborreliosis: the protocol of a multicentre, non-inferiority, double-blinded and randomised controlled trial 

      Solheim, Anne Marit; Ljøstad, Unn; Mygland, Åse (Peer reviewed; Journal article, 2019)
      Introduction: Current treatment guidelines for European Lyme neuroborreliosis (LNB) recommend cephalosporins, penicillin or doxycycline for 14–28 days but evidence for optimal treatment length is poor. Treatment lengths ...

    • Sixteen-week multicentre randomised controlled trial to study the effect of the consumption of an oat beta-glucanenriched bread versus a whole-grain wheat bread on glycaemic control among persons with pre-diabetes: a study protocol of the CarbHealth study 

      Hjorth, Therese; Schadow, Alena; Revheim, Ingrid; Spielau, Ulrike; Thomassen, Lise M.; Meyer, Klara; Piotrowski, Katja; Rosendahl-Riise, Hanne; Rieder, Anne; Varela, Paula; Lysne, Vegard; Ballance, Simon; Koerner, Antje; Landberg, Rikard; Buyken, Anette E.; Dierkes, Jutta (Journal article; Peer reviewed, 2022)
      Introduction In 2012, the estimated global prevalence of pre-diabetes was 280 million, and the prevalence is expected to rise to 400 million by 2030. Oat-based foods are a good source of beta-glucans, which have been ...

    • Sjögren’s syndrome: studying the disease in mice 

      Delaleu, Nicolas Hervé; Nguyen, Cuong Q.; Peck, Ammon B.; Jonsson, Roland (Peer reviewed; Journal article, 2011-06-13)
      Sjögren’s syndrome (SS), a systemic autoimmune disease, is characterized by infl ammation of exocrine tissues accompanied by a signifi cant loss of their secretory function. Clinical symptoms develop late and there are no ...

    • Sjøfolks syn- har vi riktig fokus på helsekrav og undersøkelsesmetode? 

      Koefoed, Vilhelm F (Journal article, 2008)
      En vanlig synsundersøkelse måler skarpsyn, men sier ingenting om evnen til å se kontraster. Spesielt i mørke, tåke eller motlys er godt kontrastsyn vel så viktig, når man holder utkikk på broen.

    • Sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study 

      Engstrøm, Morten; Hagen, Knut; Bjørk, Marte Helene; Stovner, Lars Jacob; Gravdahl, Gøril Bruvik; Stjern, Marit; Sand, Trond (Peer reviewed; Journal article, 2013-02-14)
      Background: Our aim was to compare subjective and objective sleep quality and arousal in migraine and to evaluate the relationship between sleep quality and pain thresholds (PT) in controls, interictal, preictal and postictal ...

    • Sleep-related and non-sleep-related migraine: interictal sleep quality, arousals and pain thresholds 

      Engstrøm, Morten; Hagen, Knut; Bjørk, Marte Helene; Gravdahl, Gøril Bruvik; Sand, Trond (Peer reviewed; Journal article, 2013-08-06)
      Background: The mechanisms associating sleep and migraine are unknown. No previous polysomnographic (PSG) or pain-threshold (PT) study has compared patients with sleep-related migraine attacks (SM), non-sleep related ...

    • Social media in surgery: evolving role in research communication and beyond 

      Grossman, Rebecca; Sgarbura, Olivia; Hallet, Julie; Søreide, Kjetil (Journal article; Peer reviewed, 2021)
      Purpose To present social media (SoMe) platforms for surgeons, how these are used, with what impact, and their roles for research communication. Methods A narrative review based on a literature search regarding social ...

    • SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma? 

      Kotopoulis, Spiros; Popa, Mihaela-Lucia; Mayoral Safont, Mireia; Murvold, Elsa Thodesen; Haugse, Ragnhild; Langer, Anika; Dimcevski, Georg Gjorgji; Lam, Christina; Bjånes, Tormod Karlsen; Gilja, Odd Helge; Mccormack, Emmet Matin (Journal article; Peer reviewed, 2022)
      The use of ultrasound and microbubbles to enhance therapeutic efficacy (sonoporation) has shown great promise in cancer therapy from in vitro to ongoing clinical studies. The fastest bench-to-bedside translation involves ...

    • Sosiale skilnadar i kostvanar blant ungdom i Sogn og Fjordane i perioden 1997 - 2009 

      Stokstad, Janette Moland (Master thesis, 2014-05-15)
      Social disparities in health follow a gradient through the whole population, the social gradient in health. People with higher education, better occupational status and income live on average longer lives and have better ...

    • Source control in emergency general surgery: WSES, GAIS, SIS-E, SIS-A guidelines 

      Coccolini, Federico; Sartelli, Massimo; Sawyer, Robert; Rasa, Kemal; Viaggi, Bruno; Abu-Zidan, Fikri; Søreide, Kjetil; Hardcastle, Timothy; Gupta, Deepak; Bendinelli, Cino; Ceresoli, Marco; Shelat, Vishal G.; Broek, Richard ten; Baiocchi, Gian Luca; Moore, Ernest E.; Sall, Ibrahima; Podda, Mauro; Bonavina, Luigi; Kryvoruchko, Igor A.; Stahel, Philip; Inaba, Kenji; Montravers, Philippe; Sakakushev, Boris; Sganga, Gabriele; Ballestracci, Paolo; Malbrain, Manu L. N. G.; Vincent, Jean-Louis; Pikoulis, Manos; Beka, Solomon Gurmu; Doklestic, Krstina; Chiarugi, Massimo; Falcone, Marco; Bignami, Elena; Reva, Viktor; Demetrashvili, Zaza; Di Saverio, Salomone; Tolonen, Matti; Navsaria, Pradeep; Bala, Miklosh; Balogh, Zsolt; Litvin, Andrey; Hecker, Andreas; Wani, Imtiaz; Fette, Andreas; De Simone, Belinda; Ivatury, Rao; Picetti, Edoardo; Khokha, Vladimir; Tan, Edward; Ball, Chad; Tascini, Carlo; Cui, Yunfeng; Coimbra, Raul; Kelly, Michael; Martino, Costanza; Agnoletti, Vanni; Boermeester, Marja A.; De’Angelis, Nicola; Chirica, Mircea; Biffl, Walt L.; Ansaloni, Luca; Kluger, Yoram; Catena, Fausto; Kirkpatrick, Andrew W. (Journal article; Peer reviewed, 2023)
      Intra-abdominal infections (IAI) are among the most common global healthcare challenges and they are usually precipitated by disruption to the gastrointestinal (GI) tract. Their successful management typically requires ...

    • Spastic paraplegia type 7 is associated with multiple mitochondrial DNA deletions 

      Wedding, Iselin Marie; Koht, Jeanette; Tran, Gia Tuong Thi; Misceo, Doriana; Selmer, Kaja Kristine; Holmgren, Asbjørn; Frengen, Eirik; Bindoff, Laurence; Tallaksen, Chantal; Tzoulis, Charalampos (Peer reviewed; Journal article, 2014-01-22)
      Spastic paraplegia 7 is an autosomal recessive disorder caused by mutations in the gene encoding paraplegin, a protein located at the inner mitochondrial membrane and involved in the processing of other mitochondrial ...

    • Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer 

      Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S.M.; Elfving, Hedvig; Brunnström, Hans; O'Reilly, Aine; Bosic, Martina; Gulyas, Miklos; Isaksson, Johan; Botling, Johan; Kärre, Klas; Jirström, Karin; Lamberg, Kristina; Pontén, Fredrik; Leandersson, Karin; Mezheyeuski, Artur; Micke, Patrick (Journal article; Peer reviewed, 2023)
      Introduction: Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune phenotypes in the mutational and clinicopathological ...