Blar i Department of Clinical Medicine på tittel

Viser treff 1270-1289 av 2045

    • Metallionenivåer i blod fra pasienter med metall-mot-metall-hofteprotese 

      Høl, Paul Johan; Hallan, Geir; Indrekvam, Kari (Journal article; Peer reviewed, 2021)
      Bakgrunn: BHR-protese (Birmingham hip resurfacing) er satt inn i hoften til 445 personer i Norge. Bivirkninger av metallfrigjøring fra metall-mot-metall-leddflater av kobolt-krom-legering kan forekomme. Målet med studien ...

    • A method for dierentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96‐well microplates 

      Balafkan, Novin; Mostafavi, Sepideh; Schubert, Manja; Siller, Richard; Liang, Xiao; Sullivan, Gareth; Bindoff, Laurence (Journal article; Peer reviewed, 2020)
      The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards cardiomyocytes ...

    • Microarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cysts 

      Aarhus, Mads; Helland, Christian Andre; Lund-Johansen, Morten; Wester, Knut; Knappskog, Per (Peer reviewed; Journal article, 2010-02-26)
      Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the temporal fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and ...

    • Microemboli detection in acute ischemic stroke 

      Aarli, Sander Johan (Doctoral thesis, 2021-12-10)
      Microembolic signals (MES) are detectable by transcranial Doppler monitoring and represent small, clinically silent particles in the cerebral circulation. MES are related to increased risk of first or recurrent ischemic ...

    • Microemboli-monitoring during the acute phase of ischemic stroke: Is it worth the time? 

      Idicula, Titto T.; Næss, Halvor; Thomassen, Lars (Peer reviewed; Journal article, 2010-09-10)
      Background The prevalence of microembolic signals (MES) during the acute phase of ischemic stroke and its influence on outcome is not well studied. The aim of our study was to determine the prevalence of MES, the different ...

    • MicroRNA Alterations and Associated Aberrant DNA Methylation Patterns across Multiple Sample Types in Oral Squamous Cell Carcinoma 

      Wiklund, Erik D.; Gao, Shan; Hulf, Toby; Sibbritt, Tennille; Nair, Shalima; Costea, Daniela Elena; Villadsen, Sune B.; Bakholdt, Vivi; Bramsen, Jesper B.; Sørensen, Jens A.; Krogdahl, Annelise; Clark, Susan J.; Kjems, Jørgen (Peer reviewed; Journal article, 2011-11-22)
      Background: MicroRNA (miRNA) expression is broadly altered in cancer, but few studies have investigated miRNA deregulation in oral squamous cell carcinoma (OSCC). Epigenetic mechanisms are involved in the regulation of .30 ...

    • MicroRNA-138 abates fibroblast motility with effect on invasion of adjacent cancer cells 

      Rajthala, Saroj; Parajuli, Himalaya; Dongre, Harsh Nitin; Ljøkjel, Borghild; Hoven, Kristin Marie; Kvalheim, Arild; Lybak, Stein; Neppelberg, Evelyn; Sapkota, Dipak; Johannessen, Anne Christine; Costea, Daniela Elena (Journal article; Peer reviewed, 2022-03-17)
      Background: Recent studies have shown aberrant expression of micro-RNAs in cancer-associated fibroblasts (CAFs). This study aimed to investigate miR-138 dysregulation in CAFs in oral squamous cell carcinoma (OSCC) and its ...

    • MicroRNAs as important players and biomarkers in oral carcinogenesis 

      Min, Anjie; Zhu, Chao; Peng, Shuping; Rajthala, Saroj; Costea, Daniela Elena; Sapkota, Dipak (Peer reviewed; Journal article, 2015)
      Oral cancer, represented mainly by oral squamous cell carcinoma (OSCC), is the eighth most common type of human cancer worldwide. The number of new OSCC cases is increasing worldwide, especially in the low-income countries, ...

    • MicroRNAs in Differentiation of Embryoid Bodies and the Teratoma Subtype of Testicular Cancer 

      Myklebust, Mette Pernille; Søviknes, Anne Mette; Halvorsen, Ole Johan; Thor, Anna; Dahl, Olav; Ræder, Helge (Journal article; Peer reviewed, 2022)
      Background: Testicular germ cell tumours (TGCTs) are the most frequent tumour type among young, adult men. TGCTs can be efficiently treated, but metastases of the teratoma subtype, for which there are no circulating ...

    • Microsatellite instability at tetranucleotides (EMAST) in colorectal cancer: clinical relevance, mechanisms and immune markers 

      Watson, Martin M (Doctoral thesis, 2020-06-18)
      Colorectal cancer (CRC) is the second-leading cause of cancer-related death and a global burden in terms of incidence, person-years of life lost and public health costs. About 10-20% of sporadic CRCs develop through a ...

    • Microvascular proliferation in luminal Aand basal-like breast cancer subtypes 

      Kraby, Maria Ryssdal; Krüger, Kristi; Opdahl, Signe; Vatten, Lars Johan; Akslen, Lars A.; Bofin, Anna M. (Peer reviewed; Journal article, 2015)
      Aims: The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their ...

    • Microvascular proliferation is associated with aggressive tumour features and reduced survival in lung adenocarcinoma 

      Ramnefjell, Maria; Aamelfot, Christina; Aziz, Sura Mohammed; Helgeland, Lars; Akslen, Lars A. (Peer reviewed; Journal article, 2017-10)
      Despite new treatment options in lung cancer, there is still a need for better biomarkers to assist in therapy decisions. Angiogenesis has been associated with tumour growth and dissemination, and the vascular proliferation ...

    • Microvascular proliferation is associated with high tumour blood flow by mpMRI and disease progression in primary prostate cancer 

      Børretzen, Astrid; Reisæter, Lars Anders Rokne; Ringheim, Anders; Gravdal, Karsten; Haukaas, Svein Andreas; Fasmer, Kristine Eldevik; Haldorsen, Ingfrid S.; Beisland, Christian; Akslen, Lars Andreas; Halvorsen, Ole Johan (Journal article; Peer reviewed, 2023)
      Active angiogenesis may be assessed by immunohistochemistry using Nestin, a marker of newly formed vessels, combined with Ki67 for proliferating cells. Here, we studied microvascular proliferation by Nestin-Ki67 co-expression ...

    • Minimal important change was on the lower spectrum of previous estimates and responsiveness was sufficient for core outcomes in chronic low back pain 

      Bråten, Lars Christian Haugli; Grøvle, Lars; Wigemyr, Monica; Wilhelmsen, Maja; Gjefsen, Elisabeth; Espeland, Ansgar; Haugen, Anne Julsrud; Skouen, Jan Sture; Brox, Jens Ivar; Zwart, John Anker Henrik; Storheim, Kjersti; Ostelo, Raymond WJG.; Grotle, Margreth (Journal article; Peer reviewed, 2022)
      Objectives: The objective of this study was to estimate the minimal important change (MIC) and responsiveness of core patient reported outcome measures for chronic low back pain (LBP) and Modic changes. Study Design and ...

    • Minimally invasive pancreatic surgery-where are we going? 

      Sahakyan, Mushegh; Labori, Knut Jørgen; Primavesi, Florian; Søreide, Kjetil; Stättner, Stefan; Edwin, Bjørn (Peer reviewed; Journal article, 2019-03-13)
      Background Introduced in the mid-1990s, minimally invasive pancreatic surgery (MIPS) developed slowly over the next two decades, and its real-life benefits remained unclear. Methods In this review, the current status and ...

    • Minimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps 

      Ghotbi, Jacob; Sahakyan, Mushegh; Søreide, Kjetil; Fretland, Åsmund Avdem; Røsok, Bård Ingvald; Tholfsen, Tore; Waage, Anne; Edwin, Bjørn von Gohren; Labori, Knut Jørgen; Yakub, Sheraz; Kleive, Dyre (Journal article; Peer reviewed, 2022)
      Minimally invasive pancreatoduodenectomy has gained popularity throughout the last decade. For laparoscopic pancreatoduodenectomy, some high-level evidence exists, but with conflicting results. There are currently no ...

    • Mitochondrial biomarkers and biomarkers of mitochondrial disease 

      Varhaug, Kristin Nielsen (Doctoral thesis, 2021-11-26)
      Background: Biomarkers are objective and reproducible tools that are essential for making the diagnosis and following disease development in clinical practice. Mitochondria are multifunctional organelles and the major site ...

    • Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease 

      Flønes, Irene Hana; Ricken, Gerda; Klotz, Sigrid; Lang, Alexandra; Ströbel, Thomas; Dölle, Christian; Kovacs, Gabor G.; Tzoulis, Charalampos (Journal article; Peer reviewed, 2020)
      Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual ...

    • Mitochondrial respiratory chain dysfunction—A hallmark pathology of idiopathic Parkinson’s disease? 

      Flønes, Irene Hana; Tzoulis, Charalampos (Journal article; Peer reviewed, 2022)
      Parkinson’s disease (PD) is the most common age-dependent neurodegenerative synucleinopathy. Loss of dopaminergic neurons of the substantia nigra pars compacta, together with region- and cell-specific aggregations of ...

    • Mitokondriesykdom forårsaket av m.3243A>G-mutasjonen 

      Varhaug, Kristin Nielsen; Hikmat, Omar; Bindoff, Laurence Albert (Journal article; Peer reviewed, 2022)
      Mitokondriesykdom er blant de vanligste metabolske sykdommene og er relevant for mange medisinske spesialiteter. Denne kliniske oversiktsartikkelen omtaler en av de vanligste mutasjonene bak mitokondriesykdom: m.3243A>G. ...