Browsing Department of Clinical Medicine by Title
Now showing items 1403-1422 of 2233
-
Molecular approaches to the diagnosis and evaluation of follicular lymphoma
(Doctoral thesis, 2015-05-27)Background: Molecular studies of immunoglobulin (IG) genes have provided insights into the pathogenesis of different lymphoid malignancies and allowed the development of useful diagnostic tools as well as powerful prognostic ... -
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
(Peer reviewed; Journal article, 2019)Background: Novel technology has enabled researchers to better characterize pancreatic cancers at the molecular level. We wanted to explore some of the emerging discoveries, such as molecular subclassification, use of ... -
Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
(Peer reviewed; Journal article, 2012)We characterized tumor microenvironment (TME) components of mobile tongue (MT) cancer patients in terms of overall inflammatory infiltrate, focusing on the protumorigenic/anti-inflammatory phenotypes and on cancer-associated ... -
Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNA Leu(UUR))) gene
(Peer reviewed; Journal article, 2006-11-27)The gene encoding mt-tRNALeu(UUR), MT-TL1, is a hotspot for pathogenic mtDNA mutations. Amongst the first to be described was the 3302A>G transition which resulted in a substantial accumulation in patient muscle of RNA19, ... -
Molecular mechanisms of mitochondrial dysfunction in neurodegenerative diseases
(Doctoral thesis, 2024-06-05)Bakgrunn Nevrodegenerative lidelser er komplekse lidelser i sentralnervesystemet som er typisk preget av akkumulering av feilfoldede proteiner og progressiv degenerasjon og død av sårbare cellepopulasjoner i de berørte ... -
Molecular pathogenesis of polymerase gamma-related neurodegeneration
(Peer reviewed; Journal article, 2014-07)Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration ... -
Molecular subtypes in stage II-III colon cancer defined by genomic instability: Early recurrence-risk associated with a high copy-number variation and loss of RUNX3 and CDKN2A
(Peer reviewed; Journal article, 2015-04-16)Objective: We sought to investigate various molecular subtypes defined by genomic instability that may be related to early death and recurrence in colon cancer. Methods: We sought to investigate various molecular subtypes ... -
Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences
(Peer reviewed; Journal article, 2016-12)Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 women ... -
Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
(Peer reviewed; Journal article, 2013-08)Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ... -
Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man
(Doctoral thesis, 2009-12-04)Exocrine and endocrine pancreatic disease is often observed to occur together. The close colocalization of the endocrine and exocrine tissues within one organ, as well as their common embryological ancestry, have given ... -
Month of birth and risk of multiple sclerosis: confoundingand adjustments
(Peer reviewed; Journal article, 2014-02)A month of birth effect on multiple sclerosis (MS) risk has been reported from different countries. Recent critics have suggested that this finding is caused by confounding and that adequately adjusting for year and place ... -
Morbidity and Mortality after Emergency and Urgent Colorectal Surgery for Malignant and Benign Disease
(Peer reviewed; Journal article, 2009)Abstract: Aim: The aim of this study was to determine short and long-term morbidity and mortality rates after emergency colorectal surgery for benign and malignant disease in a high volume tertiary referral hospital in ... -
More Than Fish—Framing Aquatic Animals within Sustainable Food Systems
(Journal article; Peer reviewed, 2022)Aquatic animals are diverse in terms of species, but also in terms of production systems, the people involved, and the benefits achieved. In this concept piece, we draw on literature to outline how the diversity of aquatic ... -
Mortality after hospital admission for trauma in Norway: A retrospective observational national cohort study
(Journal article; Peer reviewed, 2023)Background: National quality data for trauma care in Norway have not previously been reported. We have therefore assessed crude and risk-adjusted 30-day mortality in trauma cases after primary hospital admission on national ... -
Mortality among retired offshore divers in Norway
(Peer reviewed; Journal article, 2015)Background: Health effects of diving have been observed in divers who have not experienced any diving related accidents. The aim of the study was to study total, and cause specific mortality, in Norwegian retired professional ... -
Mortality and burden of disease associated with kidney stone disease in children and young persons (<20 years): Trends in Europe between 1990–2019 according to the Global Burden of Disease database
(Journal article; Peer reviewed, 2024)Introduction The incidence of urolithiasis in children has increased. However, research regarding the associated mortality burden group is lacking. Our objective was to evaluate trends across Europe. Material and methods ... -
Mortality and cause of death in multiple sclerosis in western Norway 1950-2021: A registry-based linkage study
(Journal article; Peer reviewed, 2022)Background Persons with multiple sclerosis (pwMS) have higher risk of mortality compared with the general population. Longitudinal studies are important for understanding the evolution of survival in pwMS. Objective ... -
Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study
(Journal article; Peer reviewed, 2021)Background: In society at large, it is debated whether use of antipsychotic drugs is associated with increased or decreased mortality among patients with schizophrenia. Large register studies have demonstrated an increased ... -
Mortality in epilepsy and the influence of comorbid conditions and antiepileptic drugs
(Doctoral thesis, 2013-05-31)Purpose: Based on a clinical observation, this study was initiated to examine whether treatment with lamotrigine (LTG) is associated with an increased risk of sudden unexpected death in epilepsy (SUDEP) in sub-groups of ...