Browsing Department of Clinical Medicine by Title
Now showing items 1940-1959 of 2057
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Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report
(Journal article; Peer reviewed, 2020)Background The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and ... -
Tumor HPV status, level of regulatory T cells and macrophage infiltration predict up to 20-year non-disease-specific survival in oropharynx squamous cell carcinoma patients
(Journal article; Peer reviewed, 2022)Oropharynx squamous cell carcinoma (OPSCC) is of special interest because human papilloma virus (HPV) and/or smoking cause this disease. Influxes of inflammatory cells into such tumors are known to vary with prognoses. ... -
Tumor infiltration levels of CD3, Foxp3 (+) lymphocytes and CD68 macrophages at diagnosis predict 5-year disease-specific survival in patients with oropharynx squamous cell carcinoma
(Journal article; Peer reviewed, 2022)Head and neck cancer (HNC) is the sixth most common cancer worldwide. Oropharyngeal (OP) cancers are of special interest because of possible underlying HPV infection which is tied to prognosis. Influxes of inflammatory ... -
Tumor necrosis is associated with increased alphav beta3 integrin expression and poor prognosis in nodular cutaneous melanomas
(Peer reviewed; Journal article, 2008-12-05)Background: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ... -
Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer
(Journal article; Peer reviewed, 2021)The tumor microenvironment plays a critical role in breast cancer progression. Here, we investigated tumor-infiltrating lymphocytes (TILs) and associations with macrophage numbers, tumor stromal elastosis, vascular invasion, ... -
Tumour texture features from preoperative CT predict high-risk disease in endometrial cancer
(Journal article; Peer reviewed, 2021-01)Background: To enable more individualised treatment of endometrial cancer, improved methods for preoperative tumour characterization are warranted. Texture analysis is a method for quantification of heterogeneity in images, ... -
Turnover of IPS employment specialists: Rates and predictors
(Journal article; Peer reviewed, 2022)Background: There are anecdotal reports of high job turnover of Individual Placement and Support employment specialists. However, no studies have addressed this issue. Objective: To explore whether turnover rates among ... -
Tweeting the meeting: Quantitative and qualitative twitter activity during the 38th ESSO conference
(Peer reviewed; Journal article, 2019-02)Introduction: Social media is increasingly used to share information with the potential for fast and wide reach. Data on use during surgical oncology conferences is limited. We aimed to monitor twitter usage during a ... -
Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases
(Journal article; Peer reviewed, 2022)Context Maturity onset diabetes of the young, type 8 (MODY8) is associated with mutations in the CEL gene, which encodes the digestive enzyme carboxyl ester lipase. Several diabetes cases and families have in recent years ... -
Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
(Peer reviewed; Journal article, 2019)Background: Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast ... -
A two-year longitudinal follow-up of cognitive performance assessed by BICAMS in newly diagnosed patients with MS
(Journal article; Peer reviewed, 2020)Background: Cognitive impairment is common in patients with multiple sclerosis (MS) and may occur at any stage and with any subtype of the disease. Screening and monitoring of cognitive function should therefore be implemented ... -
Type 1 plasminogen activator inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC) and its impact on angiogenesis, progression and patient survival after radical nephrectomy
(Peer reviewed; Journal article, 2010-12-03)Background To examine the expression of type 1 plasminogen inhibitor (PAI-1) in clear cell renal cell carcinoma (CCRCC), and its possible association with microvessel density (MVD), the expression of thrombospondin-1 ... -
Type 2 diabetes genes : present status and data from Norwegian studies
(Peer reviewed; Journal article, 2013)The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as ... -
Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
(Journal article; Peer reviewed, 2022)While DNA methylation is established as a major regulator of gene expression in the nucleus, the existence of mitochondrial DNA (mtDNA) methylation remains controversial. Here, we characterized the mtDNA methylation landscape ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
(Journal article; Peer reviewed, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasonographic evaluation of disease activity in Crohn’s Disease
(Doctoral thesis, 2020-09-21)Background: Crohn's disease (CD) is a chronic inflammatory disorder in the gastrointestinal (GI) tract, characterized by alternating periods of remission and relapse. Patients’ symptoms do not reliably represent inflammatory ... -
Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys
(Journal article; Peer reviewed, 2021-11-29)The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path ... -
Ultrasound Detection of Pneumothorax. Development of a porcine pneumothorax model to assess and teach lung ultrasound diagnostics.
(Doctoral thesis, 2013-10-21)Background: Pneumothorax (PTX) is common after blunt chest injury, and failure to diagnose and rapidly treat an enlarging PTX may cause patient death. The anteroposterior supine chest x-ray (CXR) is the least sensitive of ... -
Ultrasound echo-intensity predicts severe Pancreatic affection in cystic fibrosis patients
(Peer reviewed; Journal article, 2015-03-24)Background: Pancreatic destruction affects the majority of patients with cystic fibrosis. We aimed to relate ultrasound findings to exocrine pancreatic function and cystic fibrosis genotype. Methods: Patients with cystic ... -
Ultrasound imaging for assessing functions of the GI tract
(Journal article; Peer reviewed, 2021)Objective: In the following review we outline how ultrasound can be used to measure physiological processes in the gastrointestinal tract. Approach: We have investigated the potential of ultrasound in assessing ...