Browsing Department of Clinical Medicine by Document Types "Doctoral thesis"
Now showing items 21-40 of 286
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Brain MRI changes in Parkinson’s disease A cross sectional study
(Doctoral thesis, 2007-11-09)Background: Cognitive impairment is common even in newly diagnosed Parkinson’s disease (PD), and characteristically involves executive and visuospatial functions with deficits also in the memory domain. There is an increased ... -
Breast cancer of the young: Exploring age-related breast cancer biology
(Doctoral thesis, 2023-11-30)Brystkreft er en sykdom som i en økende grad rammer kvinner i Norge og den vestlige verden. Brystkreft blant yngre kvinner er også økende, og dessuten assosiert med mer aggressiv tumor type og verre klinisk utfall sammenlignet ... -
Burkitt Lymphoma in Uganda. A study of some biological and epidemiological aspects of endemic Burkitt lymphoma
(Doctoral thesis, 2011-08-25) -
C- reactive protein in schizophrenia-spectrum disorders; relationship to cognitive functions and medications
(Doctoral thesis, 2019-12-05)Background: Schizophrenia spectrum disorders are severe mental illnesses characterized by psychotic symptoms, cognitive dysfunction and functional decline. Cognitive impairments have been recognized as core features of ... -
Cancer and Total Hip Replacement. Cancer as a risk factor for prosthesis and prosthesis as a risk factor for cancer
(Doctoral thesis, 2015-09-18)Annually, 14 million new cancer cases are detected worldwide; the numbers are expected to rise by 70% over the next decades. In Norway, 30,000 new cancer cases are detected every year. Because of screenings and increased ... -
Cancer Stem Cell-Related Markers in Normal and Neoplastic Oral Mucosa. A study on human samples and experimental models
(Doctoral thesis, 2014-06-04)The existence of cancer stem cells (CSCs) in solid cancers is still a controversial issue. Several markers were successfully used to enrich for cells with stem cell-like properties in oral squamous cell carcinoma (OSCC). ... -
Cancer-Associated Ischemic Stroke: The Bergen NORSTROKE Study
(Doctoral thesis, 2018-05-25)Background: Stroke and cancer are both leading causes of death and disability in the Western world. Cancer can lead to a hypercoagulable state that can cause ischemic stroke. Mechanisms include disturbance of the coagulation ... -
Carboxyl ester lipase in pancreatic disease : In vitro and in vivo studies of human pathogenic CEL mutations
(Doctoral thesis, 2023-03-21)Karboksylester-lipase (CEL) er et fordøyelsesenzym som hovedsakelig er uttrykt i bukspytt-kjertelen. Det siste eksonet i CEL-genet inneholder et variabelt antall tandem repetisjoner (VNTR), altså en region av repeterte ... -
Carboxyl-ester lipase in human pancreatic disease. A study with focus on genetics, glycosylation and ABO blood groups
(Doctoral thesis, 2018-09-28)Glycosylation is a post-translational modification where carbohydrates are attached to a protein or other organic molecule. Defects in glycosylation are seen in many human pathologies and may even be the underlying cause ... -
Cardiac Arrest in a Community: Epidemiology, Treatment, and Outcome
(Doctoral thesis, 2017-09-01)Background: Incidence and mortality from sudden cardiac arrest is high, making it a prevalent cause of death. Both incidence and survival rates show great variability between populations. In order to improve survival from ... -
Carotid intima-media thickness and cerebrovascular vasoreactivity in patients with intracranial aneurysms : A sonographic study of potential predictors for aneurysm rupture risk and delayed cerebral ischemia
(Doctoral thesis, 2020-04-03)Background and aims Intracranial aneurysms can rupture and cause an aneurysmal subarachnoid hemorrhage (aSAH), a bleeding under the arachnoid meninges covering the brain. This is a devastating event, in which delayed ... -
Cerebellar degeneration-related proteins in anti-Yo associated paraneoplastic cerebellar degeneration
(Doctoral thesis, 2021-06-25)Background: Paraneoplastic neurological syndromes (PNS) are rare immune-mediated diseases triggered by cancer, and characterized by circulating onconeural antibodies directed against antigens expressed by neurons and tumor ... -
Cerebral magnetic resonance imaging in children with prenatal drug exposure. Structural and functional aspects of the opioid-exposed brain
(Doctoral thesis, 2018-02-02)Background: Over the last few decades brain imaging studies have made important contributions to our understanding of how prenatal drug exposure can impact normal brain development. The teratogenic potential of alcohol has ... -
Changing paradigms of anterior cruciate ligament surgery. From transtibial to a more anatomic approach
(Doctoral thesis, 2015-10-09)The current thesis consists of four papers evaluating results after anterior cruciate ligament reconstruction using two different surgical techniques. Paper I and II evaluate long-term outcomes after a transtibial technique ... -
Characterisation of genomic imbalances in patients with mental retardation
(Doctoral thesis, 2009-03-20)A major cause of mental retardation is chromosomal abnormalities, but due to low sensitivity of conventional chromosomal karyotyping, these abnormalities may stay undetected, and the etiology of the impairment remains ... -
Child injuries in Bergen, Norway : identifying high-risk groups and activity specific injuries
(Doctoral thesis, 2006-11-24)Sammendrag (Norwegian summary) Formålet med denne studien var å undersøke forekomsten av barneulykker i Bergen sammenliknet med forekomsten andre steder innenlands og utenlands. Vi ønsket å undersøke hvilke barn, karakterisert ... -
Chronic fatigue syndrome. Health and impairment, treatment and prognosis
(Doctoral thesis, 2008-06-06)Chronic fatigue syndrome (CFS) has been known as “neurasthenia” for more than hundred years and is today often called ME (myalgic encephalopathy), CFS/ME. The illness is characterized by excessive, prolonged and disabling ... -
Clinical and molecular studies of disease caused by mutations of the mitochondrial DNA polymerase gamma (POLG).
(Doctoral thesis, 2010-11-26)Background: Mutations in the gene encoding the DNA-polymerase gamma (POLG), the enzyme that replicates and repairs the mitochondrial genome, are an important cause of human disease and disability. Over 130 pathogenic ... -
Clinical aspects in the late stage of whiplash injury
(Doctoral thesis, 2009-11-13)