Blar i Department of Clinical Medicine på tittel
Viser treff 513-532 av 2095
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Differential transcript usage in the Parkinson’s disease brain
(Peer reviewed; Journal article, 2020)Studies of differential gene expression have identified several molecular signatures and pathways associated with Parkinson’s disease (PD). The role of isoform switches and differential transcript usage (DTU) remains, ... -
Differentiating traits and states identifies the importance of chronic neuropsychiatric symptoms for cognitive prognosis in mild dementia
(Journal article; Peer reviewed, 2021)Introduction Neuropsychiatric symptoms (NPS) in dementia are associated with poor cognitive outcomes in longitudinal studies. Whether this is due to differences in symptom burden between persons (BP) or changes within ... -
Difficult birth is the main contributor to birth‐related fracture and accidents to other neonatal fractures
(Journal article; Peer reviewed, 2020)Aim Specific birth-related fractures have been studied; underestimates might be a problem. We aimed to assess all fractures diagnosed as birth-related as well as other neonatal fractures. Methods A population-based ... -
Digital Breast Tomosynthesis : - the future screening tool for breast cancer?
(Doctoral thesis, 2022-10-31)Bakgrunn: Brystkreft er den vanligste kreftformen blant kvinner og en av de hyppigste årsakene til kreftdødsfall i Norge og globalt. Målsettingen med mammografiscreening er å oppdage brystkreft i et tidlig stadium og ... -
Digital Image Analysis of the Proliferation Markers Ki67 and Phosphohistone H3 in Gastroenteropancreatic Neuroendocrine Neoplasms: Accuracy of Grading Compared with Routine Manual Hot Spot Evaluation of the Ki67 Index
(Journal article; Peer reviewed, 2021)Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare epithelial neoplasms. Grading is based on mitotic activity or the percentage of Ki67-positive cells in a hot spot. Routine methods have poor intraobserver ... -
Disc and nerve root findings on lumbar MRI with straightened vs flexed hips and knees—pilot study
(Journal article, 2019)Objective: To compare disc and nerve root findings, image quality, and pain between supine lumbar MRI positions with straightened vs flexed hips and knees. Methods: In this prospective pilot study, 14 adults with sciatica ... -
Discovery and initial verification of differentially abundant proteins between multiple sclerosis patients and controls using iTRAQ and SID-SRM
(Peer reviewed; Journal article, 2013-01)In the present study, we aimed to discover cerebrospinal fluid (CSF) proteins with significant abundance difference between early multiple sclerosis patients and controls, and do an initial verification of these proteins ... -
Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies
(Peer reviewed; Journal article, 2011-06-28)Background: Cervical intraepithelial neoplasia (CIN) grades 2 and 3 are usually grouped and treated in the same way as “high grade”, in spite of their different risk to cancer progression and spontaneous regression rates. ... -
Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies
(Peer reviewed; Journal article, 2010-09-23)Background: To investigate disease progression the first 12 months after diagnosis in children with type 1 diabetes negative (AAB negative) for pancreatic autoantibodies [islet cell autoantibodies(ICA), glutamic acid ... -
Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation
(Journal article; Peer reviewed, 2022)Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ... -
Disease-modifying treatments for multiple sclerosis – a review of approved medications
(Peer reviewed; Journal article, 2015-11-13)Background and purpose: There is still no curative treatment for multiple sclerosis (MS), but during the last 20 years eight different disease-modifying compounds have been approved for relapsing remitting MS (RRMS). ... -
Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations
(Journal article; Peer reviewed, 2020)Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using ... -
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
(Journal article; Peer reviewed, 2022)Migraine is three times more prevalent in people with bipolar disorder or depression. The relationship between schizophrenia and migraine is less certain although glutamatergic and serotonergic neurotransmission are ... -
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
(Journal article; Peer reviewed, 2021-10-14)Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the shift ... -
Diurnal variation of motor activity in adult ADHD patients analyzed with methods from graph theory
(Journal article; Peer reviewed, 2020-11)Attention-deficit /hyperactivity disorder (ADHD) is a common neurodevelopmental syndrome characterized by age-inappropriate levels of motor activity, impulsivity and attention. The aim of the present study was to study ... -
Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction
(Journal article; Peer reviewed, 2022)Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ... -
Dixon T2 imaging of vertebral bone edema: reliability and comparison with short tau inversion recovery
(Journal article; Peer reviewed, 2022)Background It is uncertain whether T2-weighted Dixon water images (DixonT2w) and short tau inversion recovery (STIR) are interchangeable when evaluating vertebral bone edema, or if one method is superior or visualizes the ... -
Dizziness and physical health are associated with pain in dizzy patients—A cross‐sectional study
(Journal article; Peer reviewed, 2021)Background and Purpose Associations between dizziness, health-related quality of life, and musculoskeletal pain have not been systematically explored in patients with vestibular disorders. Such knowledge may be important ... -
DNA Methylation Age Acceleration Is Not Associated with Age of Onset in Parkinson's Disease
(Journal article; Peer reviewed, 2023)Background Epigenetic clocks using DNA methylation (DNAm) to estimate biological age have become popular tools in the study of neurodegenerative diseases. Notably, several recent reports have shown a strikingly similar ... -
DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion
(Journal article; Peer reviewed, 2021)Mutations in POLG, encoding POLγA, the catalytic subunit of the mitochondrial DNA polymerase, cause a spectrum of disorders characterized by mtDNA instability. However, the molecular pathogenesis of POLG-related diseases ...