Browsing Department of Clinical Medicine by Title
Now showing items 761-780 of 1354
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Labour onset and early labour. An exploration of first-time mothers’ and midwives’ experiences
(Doctoral thesis, 2011-10-28)This dissertation is about how women experience waiting for the onset of labour, and how first-time mothers and midwives communicate during the early phases of labour. Most women in Norway give birth in public hospitals, ... -
Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson’s Disease Cohorts
(Journal article; Peer reviewed, 2021)Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson’s disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on ... -
Lactate is associated with mortality in very old intensive care patients suffering from COVID-19: results from an international observational study of 2860 patients
(Journal article; Peer reviewed, 2021)Purpose: Lactate is an established prognosticator in critical care. However, there still is insufficient evidence about its role in predicting outcome in COVID-19. This is of particular concern in older patients who have ... -
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero – the Norwegian Mother and Child Cohort Study
(Peer reviewed; Journal article, 2020)Background and purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study ... -
Large-scale resting state network correlates of cognitive impairment in Parkinson’s disease and related dopaminergic deficits
(Peer reviewed; Journal article, 2014-04-03)Cognitive impairment is a common non-motor feature of Parkinson’s disease (PD). Understanding the neural mechanisms of this deficit is crucial for the development of efficient methods for treatment monitoring and augmentation ... -
Laryngeal response patterns influence the efficacy of mechanical assisted cough in amyotrophic lateral sclerosis
(Peer reviewed; Journal article, 2017)Background: Most patients with amyotrophic lateral sclerosis (ALS) are treated with mechanical insufflation–exsufflation (MI-E) in order to improve cough. This method often fails in ALS with bulbar involvement, allegedly ... -
Larynx during exercise: the unexplored bottleneck of the airways
(Peer reviewed; Journal article, 2014-07-18)Exercise-induced shortness of breath is not uncommon in otherwise healthy young people. Based on the presenting symptoms alone, it is challenging to distinguish exercise-induced asthma (EIA) from exercise-induced obstruction ... -
Larynx in exercising humans. The unexplored bottleneck of the airways
(Doctoral thesis; Peer reviewed, 2012-06-21) -
Late Onset Myasthenia Gravis Is Associated with HLA DRB1*15:01 in the Norwegian Population
(Peer reviewed; Journal article, 2012-05-09)Background: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic ... -
Late-Stage Prostate Cancer and Prostate Cancer Mortality : A Population-Based Study
(Doctoral thesis, 2019-11-29)AIMS OF THE THESIS The aim of this thesis was to provide a better understanding of the final stages of PCa, metastatic castration resistant PCa and PCa death. We further aimed to address the consequences of possible ... -
Left ventricular ejection fraction and adjudicated, cause-specific hospitalizations after myocardial infarction complicated by heart failure or left ventricular dysfunction
(Peer reviewed; Journal article, 2019)Background: Reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (MI) increases risk of cardiovascular (CV) hospitalizations, but evidence regarding its association with non-CV outcome is ... -
Left ventricular geometry and function in Tanzanian patients with hypertension and diabetes
(Doctoral thesis; Peer reviewed, 2013-02-15)From echocardiographic studies in hypertension, African Americans have been found to be more prone to develop cardiac target-organ damage than Caucasians. Hypertension is among the major upcoming health problems in Africa. ... -
Left ventricular systolic deformation in subclinical metabolic cardiomyopathies
(Doctoral thesis; Peer reviewed, 2013-02-21)Cardiovascular disease is a significant contributor to morbidity and mortality in patients with inherited metabolic disorders or chronic kidney disease. Conventional echocardiography typically identifies cardiac involvement ... -
Leg cramps in pregnancy caused by chronic compartment syndrome and relieved by fasciotomy after childbirth
(Peer reviewed; Journal article, 2014-06)Key Clinical Message A case of intolerable leg pain in pregnancy, caused by Chronic Compartment Syndrome (CCS), is presented. Increasing amounts of opioids were given throughout the pregnancy. Anesthetical dilemmas and ... -
Leptin receptor signaling regulates protein synthesis pathways and neuronal differentiation in pluripotent stem cells
(Journal article; Peer reviewed, 2020)The role of leptin receptor (OB-R) signaling in linking pluripotency with growth and development and the consequences of dysfunctional leptin signaling on progression of metabolic disease is poorly understood. Using a ... -
Leukocyte transmigration into tissue-engineered constructs is influenced by endothelial cells through Toll-like receptor signaling
(Peer reviewed; Journal article, 2014-12-20)Introduction Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial ... -
The level of inflammatory tear cytokines is elevated in congenital Aniridia and associated with meibomian gland dysfunction
(Peer reviewed; Journal article, 2018-04)Purpose: To investigate the tear cytokine profile in congenital aniridia, and correlate cytokine levels with ophthalmologic findings. Methods: We examined 35 patients with aniridia and 21 healthy controls. Tear fluid was ... -
The levels of IL-6 and soluble IL-33R are increased in the renal vein during surgery for clear cell renal cell carcinoma
(Journal article; Peer reviewed, 2021)Purpose The main aim was to map serum levels of IL-1/IL-6 family cytokines and relevant receptors from serum samples taken across treatment in patients with Renal Cell Carcinoma (RCC). Additionally, we explored the possible ... -
Linear and non-linear analyses of Conner’s Continuous Performance Test-II discriminate adult patients with attention deficit hyperactivity disorder from patients with mood and anxiety disorders
(Peer reviewed; Journal article, 2016-08-11)Background: Attention Deficit Hyperactivity Disorder (ADHD) is a heterogeneous disorder. Therefore it is important to look for factors that can contribute to better diagnosis and classification of these patients. The aims ...