Blar i Department of Biomedicine på tittel
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Characterization of porphobilinogen deaminase mutants reveals that arginine-173 is crucial for polypyrrole elongation mechanism
(Journal article; Peer reviewed, 2021)Porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthesis, catalyzes the sequential coupling of four porphobilinogen (PBG) molecules into a heme precursor. Mutations in PBGD are associated with acute ... -
Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes
(Peer reviewed; Journal article, 2019-08-01)Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and ... -
Characterization of the PLP-dependent decarboxylases GADL1 and CSAD
(Doctoral thesis, 2022-03-31)Pyridoxal 5’-phosphate (PLP) -dependent enzymes constitute an essential superfamily of enzymes for all living organisms. Due to the chemistry of their cofactor, PLP, these enzymes catalyze a wide variety of reactions. ... -
Characterization of the renal function in Epac1 (RapGef3) knockout mice
(Master thesis, 2014-06-03)The discovery of the exchange proteins directly activated by cAMP (Epac) has renewed our knowledge of intracellular cAMP signaling. The Epac1 isoform (RapGef3) shows high expression level in the kidney. In vitro studies ... -
Characterizing the heterogeneous course of inattention and hyperactivity‑impulsivity from childhood to young adulthood
(Journal article; Peer reviewed, 2021)To advance understanding of the heterogeneity in the course of ADHD, joint symptom trajectories of inattention and hyperactivity-impulsivity from childhood to young adulthood were modelled and associated with genetic, ... -
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice
(Peer reviewed; Journal article, 2011-09-23)Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet ... -
Chronic mild stress - an anmial model of depression : from behavior to molecules
(Doctoral thesis, 2006-11-03) -
A co-culture model with brain tumor-specific bioluminescence demonstrates astrocyte-induced drug resistance in glioblastoma
(Peer reviewed; Journal article, 2014-10-04)Background: Although several studies suggest that stromal fibroblasts mediate treatment resistance in several cancer types, little is known about how tumor-associated astrocytes modulate the treatment response in brain ... -
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
(Peer reviewed; Journal article, 2019)Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases (NATs) and expanded the known functions of these enzymes beyond their roles as ribosome-associated co-translational modifiers. For ... -
Cognitive and psychosocial problems in children with epilepsy : a population-based approach
(Doctoral thesis, 2007-01-12) -
Collagen Assembly at the Cell Surface: Dogmas Revisited
(Journal article; Peer reviewed, 2021)With the increased awareness about the importance of the composition, organization, and stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to understand the details of how cells ... -
Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture
(Peer reviewed; Journal article, 2014-07-11)Background: Organotypic tumor spheroids, a 3D in vitro model derived from patient tumor material, preserve tissue heterogeneity and retain structural tissue elements, thus replicating the in vivo tumor more closely than ... -
Combining microiontophoresis and multiphoton excitation microscopy to investigate neuronal signaling
(Neuromethods, Chapter; Peer reviewed, 2019)Multiphoton excitation (MPE) microscopy allows subcellular structural and functional imaging of neurons and can be combined with techniques for activating postsynaptic receptors at spatial and temporal scales that mimic ... -
Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma
(Peer reviewed; Journal article, 2014)Glioblastoma is a deadly brain cancer with limited treatment options. Targeting chondroitin sulfate proteoglycan 4 (CSPG4, best known as NG2) with the monoclonal antibody mAb9.2.27 and activated natural killer (NK) cells ... -
Common variants in the ARC gene are not associated with cognitive abilities
(Peer reviewed; Journal article, 2015-09-03)Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic ... -
Comparing Efficiency of Lysis Buffer Solutions and Sample Preparation Methods for Liquid Chromatography–Mass Spectrometry Analysis of Human Cells and Plasma
(Journal article; Peer reviewed, 2022)The use of a proper sample processing methodology for maximum proteome coverage and high-quality quantitative data is an important choice to make before initiating a liquid chromatography–mass spectrometry (LC–MS)-based ... -
Comparing Tumor Cell Invasion and Myeloid Cell Composition in Compatible Primary and Relapsing Glioblastoma
(Journal article; Peer reviewed, 2021)Glioblastoma (GBM) recurrence after treatment is almost inevitable but addressing this issue with adequate preclinical models has remained challenging. Here, we introduce a GBM mouse model allowing non-invasive and scalable ... -
Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains
(Peer reviewed; Journal article, 2011-01-24)Background: The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study we ... -
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
(Journal article; Peer reviewed, 2022)Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)-markers creatinine or cystatin C. A recommendation to use both markers in parallel ... -
Compomics-utilities: an open-source Java library for computational proteomics
(Peer reviewed; Journal article, 2011-03-08)Background The growing interest in the field of proteomics has increased the demand for software tools and applications that process and analyze the resulting data. And even though the purpose of these tools can vary ...