Blar i Department of Biomedicine på emneord "Biomedisin"
Viser treff 1-6 av 6
-
The in vivo effect of integrin α11-deficiency and PDGFR inhibition in breast cancer
(Master thesis, 2018-10-19)Background: The tumor microenvironment is a major contributor to breast cancer progression. The abnormal composition of the extracellular matrix and its deregulated interactions with stromal cells, which is characterizing ... -
Investigating the role of vitamin K in Axl-mediated melanoma progression and chemotherapeutic resistance
(Master thesis, 2018-06-29)Metastatic melanoma is a highly aggressive cancer with a very poor prognosis and current therapies remain inadequate. Norway is among the top five countries with the highest incidence of melanoma. Malignant cells carry ... -
Investigation of protein signalling pathways activated by sonoporation in cancer
(Master thesis, 2018-06-29)Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. patients with a metastatic PDAC only survive 3 – 5 months if left untreated and less than 25% of diagnosed patients are eligible for ... -
Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma
(Master thesis, 2018-06-29)Glioblastomas (GBM), a grade IV astrocytoma, is the most common and aggressive primary brain tumors in adults, associated with short survival and uniformly fatal outcome irrespective of treatment. GBM is highly heterogeneous ... -
Sensing foul AIRE: Investigating possible reporter genes for AIRE mutations
(Master thesis, 2018-06-29)The autoimmune regulator protein, known as AIRE, is a potent transcriptional regulator active in medullary thymic epithelial cells (mTECs) of the thymus, where it is able to switch on the expression of thousands of genes ... -
Toxicity and tropism of oncolytic VSV vectors in glioblastoma gene therapy
(Master thesis, 2012-11-05)Glioblastoma multiforme is the most common and most fatal primary brain tumor in adults. Despite using advanced conventional therapeutic approaches like surgical resection, radiotherapy and chemotherapy only marginal ...