Browsing Sars International Centre for Marine Molecular Biology by Title
Now showing items 75-94 of 105
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Oikopleura
(Journal article; Peer reviewed, 2020) -
Owenia fusiformis – a basally branching annelid suitable for studying ancestral features of annelid neural development
(Journal article; Peer reviewed, 2016-06-16)Background Comparative investigations on bilaterian neurogenesis shed light on conserved developmental mechanisms across taxa. With respect to annelids, most studies focus on taxa deeply nested within the annelid tree, ... -
Pairwise comparisons across species are problematic when analyzing functional genomic data
(Journal article; Peer reviewed, 2018-01-04)There is considerable interest in comparing functional genomic data across species. One goal of such work is to provide an integrated understanding of genome and phenotype evolution. Most comparative functional genomic ... -
Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction
(Journal article; Peer reviewed, 2020)Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ... -
Posterior eyespots in larval chitons have a molecular identity similar to anterior cerebral eyes in other bilaterians
(Journal article; Peer reviewed, 2015-12-22)Background: Development of cerebral eyes is generally based on fine-tuned networks and closely intertwined with the formation of brain and head. Consistently and best studied in insects and vertebrates, many signaling ... -
The Potent Respiratory System of Osedax mucofloris (Siboglinidae, Annelida) - A Prerequisite for the Origin of Bone-Eating Osedax?
(Peer reviewed; Journal article, 2012-04-25)Members of the conspicuous bone-eating genus, Osedax, are widely distributed on whale falls in the Pacific and Atlantic Oceans. These gutless annelids contain endosymbiotic heterotrophic bacteria in a branching root system ... -
Prediction of CpG-island function: CpG clustering vs. sliding-window methods
(Peer reviewed; Journal article, 2010-05-26)Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ... -
Profile analysis and prediction of tissue-specific CpG island methylation classes
(Journal article; Peer reviewed, 2009-04-21)Background: The computational prediction of DNA methylation has become an important topic in the recent years due to its role in the epigenetic control of normal and cancer-related processes. While previous prediction ... -
RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells
(Journal article; Peer reviewed, 2020-03-18)The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ... -
RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions
(Journal article; Peer reviewed, 2020)Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ... -
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
(Journal article; Peer reviewed, 2015-10-06)Notch signalling, SoxB and Group A bHLH ‘proneural’ genes are conserved regulators of the neurogenic program in many bilaterians. However, the ancestry of their functions and interactions is not well understood. We address ... -
Regulatory RNA at the root of animals: dynamic expression of developmental lincRNAs in the calcisponge Sycon ciliatum
(Journal article; Peer reviewed, 2015-12-23)Long non-coding RNAs (lncRNAs) play important regulatory roles during animal development, and it has been hypothesized that an RNA-based gene regulation was important for the evolution of developmental complexity in animals. ... -
Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes
(Journal article; Peer reviewed, 2007-10-31)A large-scale enhancer detection screen was performed in the zebrafish using a retroviral vector carrying a basal promoter and a fluorescent protein reporter cassette. Analysis of insertional hotspots uncovered areas around ... -
A safer, urea-based in situ hybridization method improves detection of gene expression in diverse animal species
(Journal article, 2017)In situ hybridization is a widely employed technique allowing spatial visualization of gene expression in fixed specimens. It has proven to be essential to our understanding of biological processes, including developmental ... -
Some like it hot: population-specific adaptations in venom production to abiotic stressors in a widely distributed cnidarian
(Journal article; Peer reviewed, 2020-09)Background: In cnidarians, antagonistic interactions with predators and prey are mediated by their venom, whose synthesis may be metabolically expensive. The potentially high cost of venom production has been hypothesized ... -
The study of Priapulus caudatus reveals conserved molecular patterning underlying different gut morphogenesis in the Ecdysozoa
(Journal article; Peer reviewed, 2015-04-21)Background The digestive systems of animals can become highly specialized in response to their exploration and occupation of new ecological niches. Although studies on different animals have revealed commonalities in gut ... -
Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes
(Journal article; Peer reviewed, 2009-08-21)Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into ... -
Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom
(Journal article; Peer reviewed, 2020)The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ... -
Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR
(Journal article; Peer reviewed, 2019)Background: In phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans-spliced with a spliced leader (SL) RNA. The functions of SL trans-splicing, however, remain largely enigmatic. Results: We ... -
Transcription start site mapping using super-low input carrier-CAGE
(Journal article; Peer reviewed, 2019-06-26)Cap analysis of gene expression (CAGE) is a method used for single-nucleotide resolution detection of RNA polymerase II transcription start sites (TSSs). Accurate detection of TSSs enhances identification and discovery of ...