Browsing Sars International Centre for Marine Molecular Biology by Title
Now showing items 1-20 of 113
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Active mode of excretion across digestive tissues predates the origin of excretory organs
(Journal article; Peer reviewed, 2019)Most bilaterian animals excrete toxic metabolites through specialized organs, such as nephridia and kidneys, which share morphological and functional correspondences. In contrast, excretion in non-nephrozoans is largely ... -
An ancient FMRFamide-related peptide-receptor pair induces defense behavior in a brachiopod larva
(Journal article, 2017)Animals show different behaviors that can consist of various spatially or temporally separated sub-reactions. Even less complex organisms, like ciliated larvae that display important behaviors (e.g. metamorphosis, defense, ... -
Ancora: a web resource for exploring highly conserved noncoding elements and their association with developmental regulatory genes
(Journal article; Peer reviewed, 2008-02-12)Metazoan genomes contain arrays of highly conserved noncoding elements (HCNEs) that span developmental regulatory genes and define regulatory domains. We describe Ancora http:// ancora.genereg.net, a web resource that ... -
The architecture of cell differentiation in choanoflagellates and sponge choanocytes
(Journal article; Peer reviewed, 2019-04-12)Although collar cells are conserved across animals and their closest relatives, the choanoflagellates, little is known about their ancestry, their subcellular architecture, or how they differentiate. The choanoflagellate ... -
Assembly and positioning of actomyosin rings by contractility and planar cell polarity
(Journal article; Peer reviewed, 2015-10-21)The actomyosin cytoskeleton is a primary force-generating mechanism in morphogenesis, thus a robust spatial control of cytoskeletal positioning is essential. In this report, we demonstrate that actomyosin contractility and ... -
Automated behavioural analysis reveals the basic behavioural repertoire of the urochordate Ciona intestinalis
(Journal article; Peer reviewed, 2019-02-20)Quantitative analysis of animal behaviour in model organisms is becoming an increasingly essential approach for tackling the great challenge of understanding how activity in the brain gives rise to behaviour. Here we used ... -
The Birth and Death of Toxins with Distinct Functions: A Case Study in the Sea Anemone Nematostella
(Journal article; Peer reviewed, 2019-05-27)The cnidarian Nematostella vectensis has become an established lab model, providing unique opportunities for venom evolution research. The Nematostella venom system is multimodal: involving both nematocytes and ectodermal ... -
Calcareous sponge genomes reveal complex evolution of α-carbonic anhydrases and two key biomineralization enzymes
(Journal article; Peer reviewed, 2014-11-25)Background: Calcium carbonate biominerals form often complex and beautiful skeletal elements, including coral exoskeletons and mollusc shells. Although the ability to generate these carbonate structures was apparently ... -
The cellular and molecular mechanisms of the notochord tubulogenesis in the marine invertebrate Ciona intestinalis
(Doctoral thesis, 2013-01-18)The biological tube is the fundamental structural design of most internal organs and body systems. Tubulogenesis involves a series of coordinated cellular processes, failure of any of which can cause severe dysfunctions ... -
Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels
(Journal article; Peer reviewed, 2020)Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ... -
Choanoflagellates and the ancestry of neurosecretory vesicles
(Journal article; Peer reviewed, 2021)Neurosecretory vesicles are highly specialized trafficking organelles that store neurotransmitters that are released at presynaptic nerve endings and are, therefore, important for animal cell–cell signalling. Despite ... -
Ciliary photoreceptors in the cerebral eyes of a protostome larva
(Peer reviewed; Journal article, 2011-03-01)Background: Eyes in bilaterian metazoans have been described as being composed of either ciliary or rhabdomeric photoreceptors. Phylogenetic distribution, as well as distinct morphologies and characteristic deployment of ... -
cis–regulation and mis–regulation – Insights into genomic regulatory mechanisms underlying the control of fgf8a in zebrafish Danio rerio
(Doctoral thesis, 2008-06-19)Fibroblast growth factor 8 (Fgf8) is a potent vertebrate morphogen that plays decisive roles in multiple developmental processes, such as cellular proliferation, survival, differentiation, growth and migration. Fgf8 ... -
Cleavage modification did not alter blastomere fates during bryozoan evolution
(Journal article; Peer reviewed, 2017-04-28)Background: Stereotypic cleavage patterns play a crucial role in cell fate determination by precisely positioning early embryonic blastomeres. Although misplaced cell divisions can alter blastomere fates and cause embryonic ... -
CNEr: A toolkit for exploring extreme noncoding conservation
(Journal article; Peer reviewed, 2019-08-26)Conserved Noncoding Elements (CNEs) are elements exhibiting extreme noncoding conservation in Metazoan genomes. They cluster around developmental genes and act as long-range enhancers, yet nothing that we know about their ... -
Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
(Journal article; Peer reviewed, 2020)The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ... -
Conservative route to genome compaction in a miniature annelid
(Journal article; Peer reviewed, 2021)The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ... -
Coordinated spatial and temporal expression of Hox genes during embryogenesis in the acoel Convolutriloba longifissura
(Journal article; Peer reviewed, 2009-10-01)Background: Hox genes are critical for patterning the bilaterian anterior-posterior axis. The evolution of their clustered genomic arrangement and ancestral function has been debated since their discovery. As acoels appear ... -
Cytoskeleton-mediated templating of complex cellulose-scaffolded extracellular structure and its association with oikosins in the urochordate Oikopleura
(Peer reviewed; Journal article, 2010)Oriented cellulose deposition is critical to plant patterning and models suggest microtubules constrain cellulose synthase movements through the plasma membrane. Though widespread in plants, urochordates are the only animals ... -
Detailed reconstruction of the musculature in Limnognathia maerski (Micrognathozoa) and comparison with other Gnathifera
(Journal article; Peer reviewed, 2014-10-01)Introduction: Limnognathia maerski is the single species of the recently described taxon, Micrognathozoa. The most conspicuous character of this animal is the complex set of jaws, which resembles an even more intricate ...