Now showing items 43-62 of 113

    • Extreme Levels of Ocean Acidification Restructure the Plankton Community and Biogeochemistry of a Temperate Coastal Ecosystem: A Mesocosm Study 

      Spisla, Carsten; Taucher, Jan; Bach, Lennart T; Haunost, Mathias; Boxhammer, Tim; King, Andrew L; Jenkins, Bettany D.; Wallace, Joselynn R.; Ludwig, Andrea; Meyer, Jana; Stange, Paul; Minutolo, Fabrizio; Lohbeck, Kai T.; Nauendorf, Alice; Kalter, Verena; Lischka, Silke; Sswat, Michael; Dörner, Isabel; Ismar-Rebitz, Stefanie M. H.; Aberle, Nicole; Yong, Jaw C; Bouquet, Jean-Marie; Lechtenbörger, Anna K.; Kohnert, Peter; Krudewig, Michael; Riebesell, Ulf (Journal article; Peer reviewed, 2021)
      The oceans’ uptake of anthropogenic carbon dioxide (CO2) decreases seawater pH and alters the inorganic carbon speciation – summarized in the term ocean acidification (OA). Already today, coastal regions experience episodic ...
    • Five New Species of Guimaraesiella (Phthiraptera: Ischnocera) from Broadbills (Aves: Passeriformes: Calyptomenidae: Eurylaimidae) 

      Gustafsson, David; Malysheva, Olga D; Tolstenkov, Oleg; Bush, Sarah E (Journal article; Peer reviewed, 2019)
      Five new species of Guimaraesiella Eichler, 1949 are described and illustrated from hosts in the Eurylaimidae and Calyptomenidae. They are Guimaraesiella corydoni n. sp. from Corydon sumatranus laoensisMeyer de Schauensee, ...
    • Functional annotation of human long noncoding RNAs via molecular phenotyping 

      Ramilowski, Jordan; Yip, Chiu Wai Mickey; Agrawal, Saumya; Chang, Jen-Chien; Ciani, Yari; Kulakovskiy, Ivan; Mendez, Mickaël; Ching Ooi, Jasmine Li; Ouyang, John F; Parkinson, Nick; Kasukawa, Takeya; Kauppinen, Sakari; Kere, Juha; Lenhard, Boris; Schneider, Claudio; Suzuki, Harukazu; Yagi, Ken; De Hoon, Michiel J L; Shin, Jay W; Piero, Carninci (Journal article; Peer reviewed, 2020)
      Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...
    • Gap junction-dependent coordination of intercellular calcium signalling in the developing appendicularian tunicate Oikopleura dioica 

      Mikhaleva, Yana; Tolstenkov, Oleg; Glover, Joel (Journal article; Peer reviewed, 2019)
      We characterized spontaneous Ca2+ signals in Oikopleura dioica embryos from pre-fertilization to gastrula stages following injection of GCaMP6 mRNA into unfertilized eggs. The unfertilized egg exhibited regular, transient ...
    • Gene expression in bryozoan larvae suggest a fundamental importance of pre-patterned blastemic cells in the bryozoan life-cycle 

      Fuchs, Judith; Martindale, Mark Q.; Hejnol, Andreas (Peer reviewed; Journal article, 2011-06-06)
      Background: Bryozoa is a clade of aquatic protostomes. The bryozoan life cycle typically comprises a larval stage, which metamorphoses into a sessile adult that proliferates by asexual budding to form colonies. The homology ...
    • Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts 

      Lu, Tsai-Ming; Furuya, Hidetaka; Satoh, Noriyuki (Journal article; Peer reviewed, 2019-11-13)
      Metazoans have evolved a great variety of life histories in response to environmental conditions. A unique example is encountered in dicyemid mesozoans. In addition to a highly simplified adult body comprising only ~ 30 ...
    • Generating transgenic reporter lines for studying nervous system development in the cnidarian nematostella vectensis 

      Rentzsch, Fabian; Renfer, Eduard; Technau, Ulrich (Journal article; Peer reviewed, 2020)
      Neurons often display complex morphologies with long and fine processes that can be difficult to visualize, in particular in living animals. Transgenic reporter lines in which fluorescent proteins are expressed in defined ...
    • The genetic basis for PRC1 complex diversity emerged early in animal evolution 

      Gahan, James; Rentzsch, Fabian; Schnitzler, Christine E. (Journal article; Peer reviewed, 2020)
      Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about ...
    • Genomic features and computational identification of human microRNAs under long-range developmental regulation 

      Sheng, Ying; Previti, Christopher (Peer reviewed; Journal article, 2011-05-27)
      Background: Recent functional studies have demonstrated that many microRNAs (miRNAs) are expressed by RNA polymerase II in a specific spatiotemporal manner during the development of organisms and play a key role in ...
    • Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates 

      Kikuta, Hiroshi; Laplante, Mary; Navrátilová, Pavla; Komisarczuk, Anna Zofia; Engström, Pär G.; Fredman, David; Akalin, Altuna; Caccamo, Mario; Sealy, Ian; Howe, Kerstin; Ghislain, Julien; Pezeron, Guillaume; Mourrain, Philippe; Ellingsen, Staale; Oates, Andrew C.; Thisse, Christine; Thisse, Bernard; Foucher, Isabelle; Adolf, Birgit; Geling, Andrea; Lenhard, Boris; Becker, Thomas S. (Peer reviewed; Journal article, 2007-03-06)
      We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding ...
    • Genomic regulatory blocks underlie extensive microsynteny conservation in insects 

      Engström, Pär G.; Sui, Shannan J. Ho; Drivenes, Øyvind; Becker, Thomas S.; Lenhard, Boris (Journal article, 2007-11-07)
      Insect genomes contain larger blocks of conserved gene order (microsynteny) than would be expected under a random breakage model of chromosome evolution. We present evidence that microsynteny has been retained to keep large ...
    • Getting to the bottom of anal evolution 

      Hejnol, Andreas; Martin Duran, Jose Maria (Journal article; Peer reviewed, 2015-02-27)
      The digestive tract is an essential organ system that allows animals to efficiently digest food and take up nutrients to maintain growth and sustain the body. While some animal groups possess a sack-like gut, others possess ...
    • Glypican1/2/4/6 and sulfated glycosaminoglycans regulate the patterning of the primary body axis in the cnidarian Nematostella vectensis 

      Bause, Markus; van der Horst, Roddy; Rentzsch, Fabian (Journal article; Peer reviewed, 2016-06)
      Glypicans are members of the heparan sulfate (HS) subfamily of proteoglycans that can function in cell adhesion, cell crosstalk and as modulators of the major developmental signalling pathways in bilaterians. The evolutionary ...
    • Heterogenic Origin of Micro RNAs in Atlantic Salmon (Salmo salar) Seminal Plasma 

      Bizuayehu, Teshome Tilahun; Babiak, Igor (Journal article; Peer reviewed, 2020)
      The origin and contribution of seminal plasma RNAs into the whole semen RNA repertoire are poorly known, frequently being overlooked or neglected. In this study, we used high-throughput sequencing and RT-qPCR to profile ...
    • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis 

      Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)
      Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ...
    • Histone variant innovation in a rapidly evolving chordate lineage 

      Moosmann, Alexandra; Campsteijn, Coen; Jansen, Pascal W. T. C.; Nasrallah, Carole; Raasholm, Martina; Stunnenberg, Henk G; Thompson, Eric M. (Peer reviewed; Journal article, 2011-07-15)
      Background: Histone variants alter the composition of nucleosomes and play crucial roles in transcription, chromosome segregation, DNA repair, and sperm compaction. Modification of metazoan histone variant lineages occurs ...
    • Hox gene expression during development of the phoronid Phoronopsis harmeri 

      Gasiorowski, Ludwik; Hejnol, Andreas H. (Journal article; Peer reviewed, 2020)
      Background: Phoronida is a small group of marine worm-like suspension feeders, which together with brachiopods and bryozoans form the clade Lophophorata. Although their development is well studied on the morphological ...
    • Hox gene expression in postmetamorphic juveniles of the brachiopod Terebratalia transversa 

      Gasiorowski, Ludwik; Hejnol, Andreas (Journal article; Peer reviewed, 2019-01-08)
      Background: Hox genes encode a family of homeodomain containing transcription factors that are clustered together on chromosomes of many Bilateria. Some bilaterian lineages express these genes during embryogenesis in spatial ...
    • In Silico Detection of Sequence Variations Modifying Transcriptional Regulation 

      Andersen, Malin C.; Engström, Pär G.; Lithwick, Stuart; Lithwick, David; Eriksson, Per; Lenhard, Boris; Wasserman, Wyeth W.; Odeberg, Jacob (Journal article; Peer reviewed, 2008-01-18)
      Identification of functional genetic variation associated with increased susceptibility to complex diseases can elucidate genes and underlying biochemical mechanisms linked to disease onset and progression. For genes linked ...
    • Increased taxon sampling reveals thousands of hidden orthologs in flatworms 

      Martin Duran, Jose Maria; Ryan, Joseph Francis; Vellutini, Bruno Cossermelli; Pang, Kevin Scott; Hejnol, Andreas (Journal article; Peer reviewed, 2017)
      Gains and losses shape the gene complement of animal lineages and are a fundamental aspect of genomic evolution. Acquiring a comprehensive view of the evolution of gene repertoires is limited by the intrinsic limitations ...