Browsing Department of Clinical Science by Title
Now showing items 1634-1653 of 2343
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Patterns of genomic evolution in advanced melanoma
(Peer reviewed; Journal article, 2018-07-10)Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ... -
Påvirkning av stabilisator i phytantriol-baserte kubosomer og dens potensielle anvendelse som intravenøs levering av lumefantrin
(Master thesis, 2023-06-05)Malaria er en parasittsykdom som tar livet av nesten av en halv million mennesker hvert år. Malariabyrden har gått betraktelig ned på verdensbasis, men for 84 land gjenstår det å utrydde sykdommen. Lumefantrin (LUM) i ... -
Påvising av aminoglykosidresistens ved hjelp av massespektrometri. Utvikling av metode for deteksjon, stabilitet av aminoglykosid og molekylær karakterisering av teststammer
(Master thesis, 2014-05-20)Aminoglykosid er potente antibiotika som vert brukt til behandling av alvorlege infeksjonar med aerobe bakteriar. Dei er baktericide og verkar ved å binda til ribosoma i bakteriane og på denne måten forstyrra den normale ... -
PCR based Malaria diagnostics : – Method development and application
(Doctoral thesis, 2019-11-12)Background Almost half of the world’s population is at risk of malaria. Malaria is a parasitic vector borne disease spread by infected female Anopheles mosquitos. The protozoan parasite belongs to the genus Plasmodium ... -
PCR targeting Plasmodium mitochondrial genome of DNA extracted from dried blood on filter paper compared to whole blood
(Peer reviewed; Journal article, 2014-04-07)Background: Monitoring mortality and morbidity attributable to malaria is paramount to achieve elimination of malaria. Diagnosis of malaria is challenging and PCR is a reliable method for identifying malaria with high ... -
Peak oxygen uptake and breathing pattern in COPD patients – a four-year longitudinal study
(Peer reviewed; Journal article, 2015-08-19)Background: Activities of daily living in patients with chronic obstructive pulmonary disease (COPD) are limited by exertional dyspnea and reduced exercise capacity. The aims of the study were to examine longitudinal changes ... -
Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage: Kinetic profile, relationship to interleukin 6 and infarct size
(Journal article; Peer reviewed, 2020)Background: The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic ... -
Peptide receptor radionuclide therapy in gastroenteropancreatic NEN G3: A multicenter cohort study
(Peer reviewed; Journal article, 2019)Peptide receptor radionuclide therapy (PRRT) is an established treatment of metastatic neuroendocrine tumors grade 1–2 (G1–G2). However, its possible benefit in high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms ... -
Perceived barriers in family-based behavioural treatment of paediatric obesity – Results from the FABO study
(Journal article; Peer reviewed, 2023)Background: To date, few studies have investigated perceived barriers among those who participate in and drop out of family-based behavioural treatment (FBT) for paediatric obesity. Examining experienced barriers during ... -
Perceived Health Status: Is Obesity Perceived as a Risk Factor and Disease?
(Peer reviewed; Journal article, 2017)One might expect that a perception of obesity being a risk factor and disease, contributes to effective obesity prevention and management strategies. However, obesity rates continue to increase worldwide. The question ... -
Perceived risk profile and treatment optimization in heart failure: an analysis from BIOlogy Study to TAilored Treatment in chronic heart failure
(Journal article; Peer reviewed, 2021)Background Achieving target doses of angiotensin-converting-enzyme inhibitor/angiotensin-receptor blockers (ACEi/ARB) and beta-blockers in heart failure with reduced ejection fraction (HFrEF) is often underperformed. In ... -
Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study
(Journal article; Peer reviewed, 2022)Objective: To determine patient perceptions of generic medicines 2 and 6 months after percutaneous coronary intervention (PCI), and to determine whether these perceptions moderate medication adherence. Design: Prospective ... -
Perfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: association with fish consumption and unfavorable lipid profile
(Journal article; Peer reviewed, 2020)Objectives To examine concentrations of perfluoroalkyl substances (PFASs) and lifestyle factors that may contribute to higher levels of pollutants in never-pregnant women of fertile age. Design Observational ... -
Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimen
(Peer reviewed; Journal article, 2015-02)Personalized cancer care requires reliable biomarkers. While the BRAF V600E mutation is implemented in the clinic, no method for its detection has so far been established as reference. We aimed to perform a comprehensive ... -
Performance of an active fixation bipolar left ventricular lead vs passive fixation quadripolar leads in cardiac resynchronization therapy, a randomized trial
(Journal article; Peer reviewed, 2021)Background Usage of active fixation bipolar left ventricular (LV) leads represents an alternative approach to the more commonly used passive fixation quadripolar leads in cardiac resynchronization therapy (CRT). We compared ... -
The Performances of Three Commercially Available Assays for the Detection of SARS‐CoV‐2 Antibodies at Different Time Points Following SARS‐CoV‐2 Infection
(Journal article; Peer reviewed, 2022)The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points ... -
The Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome in children. Clinical and immunological aspects
(Doctoral thesis, 2015-09-11)Background: The Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis (PFAPA) syndrome, first described in 1987, is defined by clinical criteria. With onset during early childhood, the affected children ... -
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
(Peer reviewed; Journal article, 2017-07-10)Background Delirium is common in hip fracture patients and many risk factors have been identified. Controversy exists regarding the possible impact of intraoperative control of blood pressure upon acute (delirium) and long ... -
Peripheral and central macrophages in obesity
(Journal article; Peer reviewed, 2023)Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ... -
Peripheral blood cells from patients with autoimmune Addison's disease poorly respond to interferons in vitro, despite elevated serum levels of interferon-inducible chemokines
(Peer reviewed; Journal article, 2015-05-15)Autoimmune Addison's disease (AAD) is a disorder caused by an immunological attack on the adrenal cortex. The interferon (IFN)-inducible chemokine CXCL10 is elevated in serum of AAD patients, suggesting a peripheral IFN ...