Now showing items 1141-1160 of 1183

    • UGT1A4 og UGT2B15 enkeltnukleotidpolymorfismer. Etablering av real time PCR metoder og betydning for tamoxifen metabolisme 

      Ness, Ole-Johan (Master thesis, 2008-06-02)
      Brystkreft er den vanligste kreftformen blant kvinner i Norge og adjuvant tamoxifenbehandling er vist å øke tilbakefallsfri og total overlevelse. Den interinidividuelle varaiasjonen i effekt og bivirkninger av tamoxifen ...
    • Ultrasonography of major salivary glands in primary and juvenile Sjögren’s syndrome 

      Hammenfors, Daniel S. (Doctoral thesis, 2019-06-07)
      Background: Primary Sjögrens’s syndrome (pSS) is a systemic autoimmune disease, mainly affecting the salivary and lacrimal glands. Primary SS can also affect the younger population and when it does, the denomination is ...
    • Ultrasound in Crohn’s Disease - bowel wall characteristics and perfusion estimates using microbubbles 

      Nylund, Kim (Doctoral thesis; Peer reviewed, 2013-01-18)
      Crohn’s disease (CD) is a chronic inflammatory bowel disease which often presents early in life and sometimes can be debilitating. The patients need frequent diagnostic work-up to assess disease activity, location, extent ...
    • Ultrasound- and Microbubble-Assisted Gemcitabine Delivery to Pancreatic Cancer Cells 

      Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen; Kamceva, Tina; Gjertsen, Bjørn Tore; Gilja, Odd Helge; Schjøtt, Jan; Riedel, Bettina; McCormack, Emmet (Journal article; Peer reviewed, 2020)
      Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death worldwide. Poor drug delivery to tumours is thought to limit chemotherapeutic treatment efficacy. Sonoporation combines ultrasound (US) and microbubbles ...
    • Undersøke sammenhengen mellom jernstatus og jernabsorpsjon. Sammenligning av friske og pasienter med hemokromatose 

      Bø, Eirik Svandal (Master thesis, 2008-06-01)
      Jern er et essensielt spormetall som vi har ca 3-4 g av i kroppen. Jern inngår i flere proteiner, der hemoglobin er det viktigste. Jern er også delaktig i flere redoksreaksjoner i kroppen vår. Vi trenger daglig et tilskudd ...
    • Unexplained chronic liver disease in Ethiopia: a cross-sectional study 

      Orlien, Stian Magnus Staurung; Ismael, Nejib Yusuf; Ahmed, Tekabe Abdosh; Berhe, Nega; Lauritzen, Trine; Roald, Borghild; Goldin, Robert David; Stene-Johansen, Kathrine; Dyrhol-Riise, Anne Ma; Gundersen, Svein Gunnar; Morgan, Marsha Yvonne; Johannessen, Asgeir (Peer reviewed; Journal article, 2018-02-13)
      Background: Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence ...
    • Unexplained, self-reported food hypersensitivity. Explorative studies on mechanisms of abdominal symptom generation 

      Valeur, Jørgen (Doctoral thesis, 2010-10-08)
      Background: Self-reported food hypersensitivity remains unexplained in most cases. Abdominal symptoms, typically consistent with the irritable bowel syndrome (IBS), are common in patients with such unexplained, self-reported ...
    • Unperturbed cytotoxic lymphocyte phenotype and function in myalgic encephalomyelitis/chronic fatigue syndrome patients 

      Theorell, Jakob; Bileviciute-Ljungar, Indre; Tesi, Bianca; Schlums, Heinrich; Johnsgaard, Mette Sophie; Asadi-Azarbaijani, Babak; Strand, Elin Bolle; Bryceson, Yenan (Peer reviewed; Journal article, 2017-06-26)
      Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a debilitating disorder linked to diverse intracellular infections as well as physiological stress. Cytotoxic lymphocytes combat intracellular infections. ...
    • Unsupervised clustering of missense variants in HNF1A using multidimensional functional data aids clinical interpretation 

      Althari, Sara; Najmi, Laeya Abdoli; Bennett, Amanda J.; Aukrust, Ingvild; Rundle, Jana K.; Colclough, Kevin; Molnes, Janne; Kaci, Alba; Nawaz, Sameena; van der Lugt, Timme; Hassanali, Neelam; Mahajan, Anubha; Molven, Anders; Ellard, Sian; McCarthy, Mark I.; Bjørkhaug, Lise; Njølstad, Pål Rasmus; Gloyn, Anna L. (Journal article; Peer reviewed, 2020-10-01)
      Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A variants can cause maturity-onset diabetes of the young (MODY), ...
    • Update on primary sclerosing cholangitis 

      Karlsen, Tom Hemming; Boberg, Kirsten Muri (Peer reviewed; Journal article, 2013-09)
      Primary sclerosing cholangitis (PSC) remains one of the most challenging conditions of clinical hepatology. There has been a steady growth in research to overcome this fact and the present review aims at summarizing the ...
    • The urban-rural gradient in asthma: A population-based study in Northern Europe 

      Timm, Signe; Frydenberg, Morten; Janson, Christer; Campbell, Brittany; Forsberg, Bertil; Gíslason, Þórarinn; Holm, Mathias; Jõgi, Rain; Omenaas, Ernst; Sigsgaard, Torben; Svanes, Cecilie; Schlünssen, Vivi (Peer reviewed; Journal article, 2015-12-30)
      The early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate ...
    • Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial 

      Borowczyk, Kamila; Piechocka, Justyna; Głowacki, Rafał; Dhar, Indu; Midttun, Øivind; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Jakubowski, Hieronim (Peer reviewed; Journal article, 2018)
      Objectives: No individual homocysteine (Hcy) metabolite has been studied as a risk marker for coronary artery disease (CAD). Our objective was to examine Hcy‐thiolactone, a chemically reactive metabolite generated by ...
    • Use of conditional centiles of middle cerebral artery pulsatility index and cerebroplacental ratio in the prediction of adverse perinatal outcomes 

      Karlsen, Henriette Odland; Ebbing, Cathrine; Rasmussen, Svein; Kiserud, Torvid; Johnsen, Synnøve L. (Journal article, 2016-06)
      Introduction. Centiles of middle cerebral artery pulsatility index and cerebroplacental ratio are useful for predicting adverse perinatal outcomes. A ‘conditional centile’ is conditioned by a previous measurement reflecting ...
    • Use of loop diuretics is associated with increased mortality in patients with suspected coronary artery disease, but without systolic heart failure or renal impairment: an observational study using propensity score matching 

      Schartum-Hansen, Hall; Løland, Kjetil Halvorsen; Svingen, Gard Frodahl Tveitevåg; Seifert, Reinhard; Pedersen, Eva Ringdal; Nordrehaug, Jan Erik; Bleie, Øyvind; Ebbing, Marta; Berge, Christ; Nilsen, Dennis W.T.; Nygård, Ottar (Peer reviewed; Journal article, 2015-06-01)
      Background Loop diuretics are widely used in patients with heart and renal failure, as well as to treat hypertension and peripheral edema. However, there are no randomized, controlled trials (RCT) evaluating their long ...
    • Use of microbiology tests in the era of increasing AMR rates- a multicentre hospital cohort study 

      Skodvin, Brita; Wathne, Jannicke Slettli; Lindemann, Paul Christoffer; Harthug, Stig; Nilsen, Roy Miodini; Charani, Esmita; Syre, Heidi; Kittang, Bård Reiakvam; Kleppe, Lars Kåre Selland; Smith, Ingrid (Peer reviewed; Journal article, 2019-02-04)
      Background: Effective use of microbiology test results may positively influence patient outcomes and limit the use of broad-spectrum antibiotics. However, studies indicate that their potential is not fully utilized. We ...
    • Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study 

      Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laupsa-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Meyer, Klaus; McCann, Adrian; Andersen, Lene Frost; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2019-04-26)
      Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ...
    • Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice 

      Wohlbold, Teddy John; Nachbagauer, Raffael; Xu, Haoming; Tan, Gene S.; Hirsh, Ariana; Brokstad, Karl Albert; Cox, Rebecca Jane; Palese, Peter; Krammer, Florian (Peer reviewed; Journal article, 2015-03-10)
      In an attempt to assess the cross-protective potential of the influenza virus neuraminidase (NA) as a vaccine antigen, different subtypes of recombinant NA were expressed in a baculovirus system and used to vaccinate mice ...
    • Validation of Chichewa short musculoskeletal function assessment (SMFA) questionnaire: A cross-sectional study 

      Chokotho, Linda; Lau, Brian C.; Conway, Devin; Wu, Hao-Hua; Shearer, David; Hallan, Geir; Gjertsen, Jan-Erik; Mkandawire, Nyengo; Young, Sven (Peer reviewed; Journal article, 2019-03)
      Background: The Short Musculoskeletal Function Assessment (SMFA) tool measures function and quality of life in patients with musculoskeletal conditions. Objective: This study aimed to translate and adapt culturally the ...
    • Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration 

      Liu, Xueping; Helenius, Dorte; Skotte, Line; Beaumont, Robin N.; Wielscher, Matthias; Geller, Frank; Juodakis, Julius; Mahajan, Anubha; Bradfield, Jonathan P.; Lin, Frederick T.J.; Vogelezang, Suzanne; Bustamante, Mariona; Ahluwalia, Tarunveer S.; Pitkänen, Niina; Wang, Carol A.; Bacelis, Jonas; Borges, Maria C.; Zhang, Ge; Bedell, Bruce A.; Rossi, Robert M.; Skogstrand, Kristin; Peng, Shouneng; Thompson, Wesley Kurt; Appadurai, Vivek; Lawlor, Debbie A.; Kalliala, Ilkka; Power, Christine; McCarthy, Mark I.; Boyd, Heather A.; Marazita, Mary L.; Hakonarson, Hakon; Hayes, M. Geoffrey; Scholtens, Denise M.; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Vinding, Rebecca K.; Bisgaard, Hans; Knight, Bridget A.; Pahkala, Katja; Raitakari, Olli; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Fadista, João; Schork, Andrew J.; Nudel, Ron; Miller, Daniel E.; Chen, Xiaoting; Weirauch, Matthew T.; Mortensen, Preben Bo; Børglum, Anders D.; Nordentoft, Merete; Mors, Ole; Hao, Ke; Ryckman, Kelli K.; Hougaard, David M.; Kottyan, Leah C.; Pennell, Craig E.; Lyytikäinen, Leo-Pekka; Bønnelykke, Klaus; Vrijheid, Martine; Felix, Janine F.; Lowe, William L.; Grant, Struan F.A.; Hyppönen, Elina; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Muglia, Louis J.; Murray, Jeffrey C.; Freathy, Rachel M.; Werge, Thomas M.; Melbye, Mads; Buil, Alfonso; Feenstra, Bjarke (Peer reviewed; Journal article, 2019-09-02)
      The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ...
    • Variasjoner i bruk av psykofarmaka ved sykehjem i Trondheim kommune 

      Hjortland, Anja (Master thesis, 2019-06-22)
      Sykehjemspasientene er blant den skjøreste pasientpopulasjonen, mer enn 80% av sykehjemspasienter har demens, og flere av disse bruker en eller flere psykotrope legemidler daglig. Når kroppen blir eldre er det mye som ...