Browsing Department of Clinical Science by Title
Now showing items 1666-1685 of 2348
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Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response
(Journal article; Peer reviewed, 2021)Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 ... -
Personal Cancer Genome Reporter: Variant interpretation report for precision oncology
(Peer reviewed; Journal article, 2018-05)Individual tumor genomes pose a major challenge for clinical interpretation due to their unique sets of acquired mutations. There is a general scarcity of tools that can (i) systematically interrogate cancer genomes in the ... -
Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial
(Journal article; Peer reviewed, 2023)Imipenem/cilastatin/relebactam is approved for the treatment of serious gram-negative bacterial infections in adults. This study assessed the pharmacokinetics (PK), safety, and tolerability of a single dose of imipenem/c ... -
Pharmacokinetics, transcriptional changes and oxidative stress in pink shrimp (Pandalus montagui) exposed to teflubenzuron
(Master thesis, 2017-06-28)In the recent years, infestation with salmon lice has become a major problem in salmonid farms, and has resulted in great economic losses and reduced welfare for farmed salmonids. To enhance the salmon lice combat, there ... -
Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
(Peer reviewed; Journal article, 2019)Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ... -
Pharmacological treatment of Autoimmune Polyendocrine Syndrome type I with Rapamycin, a mTOR inhibitor
(Master thesis, 2020-06-12) -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
(Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Phenazine 5,10-dioxide analogues as drugs against acute myeloid leukaemia. -Preclinical documentation for lead selection
(Master thesis, 2018-06-29)Background: Acute Myeloid Leukaemia (AML) is a form of cancer that is associated with low survival rates, and where the current treatment is impaired by low tolerance and severe side-effects. Thus, novel treatments are ... -
Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods
(Journal article; Peer reviewed, 2021)Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ... -
Phenotypic diversity of human adipose tissue-resident NK cells in obesity
(Journal article; Peer reviewed, 2023-02-22)Natural killer (NK) cells have emerged as key mediators of obesity-related adipose tissue inflammation. However, the phenotype of NK cell subsets residing in human adipose tissue are poorly defined, preventing a detailed ... -
The pholcodine Case. Cough Medicines, IgE-Sensitization, and Anaphylaxis: A Devious Connection
(Peer reviewed; Journal article, 2012-07-15)The Scandinavian data on pholcodine (PHO) strongly indicates that there is a biological chain from PHO exposure through IgE-sensitization to IgE-mediated anaphylaxis to neuromuscular blocking agents (NMBA). PHO is probably ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
(Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
(Peer reviewed; Journal article, 2015-07-16)Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have ... -
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
(Peer reviewed; Journal article, 2014-05-17)Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. ... -
Physical activity and exercise capacity in survivors of preterm birth : A population-based cohort study of long-term consequences of prematurity
(Doctoral thesis, 2022-05-19)Background: Physical activity (PA) is an important mediator of health. Extremely preterm (EP) (<28 weeks’ gestation) and extremely low birth weight (ELBW) (<1000 g) subjects are at increased risk of long-term sequelae that ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
(Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Physical activity, exercise and cardiac troponins: Clinical implications
(Peer reviewed; Journal article, 2019)Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are ... -
Physical and cognitive performance after blood donation : A clinical study to investigate donor safety in walking blood banks
(Doctoral thesis, 2023-06-13)De siste 20 årene har fullblod til pasienter i blødningssjokk blitt re-lansert som foretrukket behandling. I vandrende blodbanker blir blodet oppbevart i original forpakningen inntil behovet oppstår. Konseptet har logistiske ...