Browsing Department of Clinical Science by Title
Now showing items 1686-1705 of 2348
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Physiotherapy improves symptoms of exercise-induced laryngeal obstruction in young elite athletes: A case series
(Peer reviewed; Journal article, 2019)Objective: A constricted, upper chest breathing pattern and postural dealignments habitually accompany exercise-induced laryngeal obstruction (EILO), but there are few effective treatments for athletes presenting with EILO. ... -
Phytochemical Observations on European Mistletoe (Viscum album L.)
(Master thesis, 2009-06-12)Non-polar constituents were extracted from Viscum album with hexane, by Soxhlet extraction. The extract was analysed by gas chromatography - mass spectrometry, and the following fatty acids, methyl esters and triterpenes ... -
Phytochemicals as a Source of Novel Drugs Against Prostate Cancer - Preparation of Animal Experiments and Isolation and Identification of Flavonoid Glycosides from Abies pindrow
(Master thesis, 2012-05-21)Introduction: Plants and herbs have been utilized for centuries by traditional medicinal systems (e.g. TCM, Ayurveda) to alleviate minor illnesses and major diseases. In recent decades, interest in traditional medicine has ... -
The PI3K-Akt-mTOR intracellular signaling pathway in human acute myeloid leukemia
(Doctoral thesis, 2019-03-08)Acute myeloid leukemia (AML) is a heterogeneous malignancy where disruption of normal intracellular signaling occurs due to mutations or abnormal external signaling. Many pathways have emerged as potential targets for ... -
The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal ... -
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer
(Peer reviewed; Journal article, 2017-08-31)Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship ... -
PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2023-03-21)Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to ... -
A Pilot Evaluation of p53 Activating Therapy as a Novel Strategy in the Treatment of Acute Myeloid Leukaemia
(Master thesis, 2008-06-08)p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. While mutations in p53 ... -
A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies.
(Journal article; Peer reviewed, 2020)Background and Objectives: Autologous and allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies, and monocytes are probably involved in hematological reconstitution as well ... -
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation
(Peer reviewed; Journal article, 2018-07)Interleukin (IL)‐6 is an important regulator of immunity and inflammation in many diseases. Single nucleotide polymorphisms (SNPs) in the IL‐6 gene influence outcome after allogeneic stem cell transplantation (ASCT), but ... -
Place of upbringing in early childhood as related to inflammatory bowel diseases in adulthood: A population-based cohort study in Northern Europe
(Peer reviewed; Journal article, 2014-06)Background The two inflammatory bowel diseases (IBD), ulcerative colitis and Crohn's disease, has increased rapidly during the twentieth century, but the aetiology is still poorly understood. Impaired immunological competence ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
(Journal article; Peer reviewed, 2018)Introduction Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ... -
Placental weight centiles adjusted for age, parity and fetal sex
(Journal article; Peer reviewed, 2022)Introduction The weight of the placenta can be indicative of efficacy in nutrient and oxygen supply. Furthermore, it has been suggested that a measure of the placenta's ability to adequately supply nutrients to the fetus ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
(Journal article; Peer reviewed, 2021)Objective: Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ... -
Plasma Cholesterol- and Body Fat-Lowering Effects of Chicken Protein Hydrolysate and Oil in High-Fat Fed Male Wistar Rats
(Journal article; Peer reviewed, 2022)Rest raw materials provide a new source of bioactive dietary ingredients, and this study aimed to determine the health effects of diets with chicken protein hydrolysate (CPH) and chicken oil (CO) generated from deboned ... -
Plasma cotinine is positively associated with homocysteine in smokers but not in users of smokeless tobacco
(Journal article; Peer reviewed, 2021)Plasma total homocysteine (tHcy) is a risk marker, and smoking is an established risk factor for cardiovascular disease. It is unclear if the effect of smoked tobacco on homocysteine is mediated by nicotine or other ... -
Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris
(Peer reviewed; Journal article, 2018)Background: Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, ... -
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris
(Peer reviewed; Journal article, 2015)Background Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. ... -
Plasma growth differentiation factor-15 is an independent marker for aggressive disease in endometrial cancer
(Peer reviewed; Journal article, 2019)Objective: Better biomarkers are needed in order to identify patients with endometrial carcinoma at risk of recurrence and who may profit from a more aggressive treatment regimen. Our objective was to explore the applicability ... -
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
(Journal article; Peer reviewed, 2020)Background The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic ...