Browsing Department of Clinical Science by Title
Now showing items 1851-1870 of 2404
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Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study
(Peer reviewed; Journal article, 2015-03)n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ... -
Problemresepter i sykehusapotek - forekomst, oppfølging og dokumentasjon av potensielt kliniske problemer.
(Master thesis, 2020-06-30)Apotekfarmasøyter har som nøkkeloppgaver å sikre riktig og trygg legemiddelbruk hos befolkningen, og de utgjør ofte et av de siste leddene i kontroll og kvalitetssikring av legers forskrivninger, før legemidlene når ... -
Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
(Journal article; Peer reviewed, 2023)Background: Extracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type ... -
Produksjon av EPA- og DHA-konsentrat fra frysetørket silderogn og sildemelke ved hjelp av ureakompleksering
(Master thesis, 2012-08-29)Herring roe and milt are high in omega-3 fatty acids that are proven to have various health benefits. The effects are best documented for cardiovascular disease, as well as inflammatory disorders such as arthritis. The ... -
Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area
(Journal article; Peer reviewed, 2022)Objective: We hypothesised that patients with asymptomatic aortic stenosis (AS) who remain with discordantly graded aortic valve stenosis (DGAS) after adjustment for pressure recovery in the aortic root represents a subgroup ... -
Prognostic impact of vitamin B6 metabolism in lung cancer
(Peer reviewed; Journal article, 2012-08-30)Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ... -
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
(Peer reviewed; Journal article, 2016-08)Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ... -
Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway
(Peer reviewed; Journal article, 2015)BACKGROUND: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist. OBJECTIVES: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients ... -
Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy – The randomized NORDIC9-study
(Journal article; Peer reviewed, 2023)Introduction Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Peer reviewed; Journal article, 2012-01-25)Background: Today’s clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced ... -
The prognostic value of pre-treatment circulating biomarkers of systemic inflammation (CRP, dNLR, YKL-40, and IL-6) in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—The Randomized NORDIC9-Study
(Journal article; Peer reviewed, 2022)Appropriate patient selection for palliative chemotherapy is crucial in patients with metastatic colorectal cancer (mCRC). We investigated the prognostic value of C-reactive protein (CRP), derived neutrophil-to-lymphocyte ... -
Prognostic value of the diversity of nuclear chromatin compartments in gynaecological carcinomas
(Journal article; Peer reviewed, 2020)Statistical texture analysis of cancer cell nuclei stained for DNA has recently been used to develop a pan-cancer prognostic marker of chromatin heterogeneity. In this study, we instead analysed chromatin organisation by ... -
The progression of acute myeloid leukemia from first diagnosis to chemoresistant relapse: A comparison of proteomic and phosphoproteomic profiles
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of the patients who receive the most intensive treatment develop chemoresistant leukemia relapse. Although the leukemogenic events leading ... -
Progression of renal disease. Pathogenetic aspects and treatment options
(Doctoral thesis, 2012-02-17) -
Prolonged and persistent diarrhoea is not restricted to children with acute malnutrition: an observational study in Ethiopia
(Peer reviewed; Journal article, 2019)Objectives: To assess the prevalence of prolonged and persistent diarrhoea, to estimate their co‐occurrence with acute malnutrition and association with demographic and clinical factors. Methods: Case–control study where ... -
Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice
(Journal article; Peer reviewed, 2023)Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ... -
A proposed method to investigate reliability throughout a questionnaire
(Peer reviewed; Journal article, 2011-10-05)Background: Questionnaires are used extensively in medical and health care research and depend on validity and reliability. However, participants may differ in interest and awareness throughout long questionnaires, which ... -
A prospective observational study on newborn resuscitation in a high-resource setting
(Doctoral thesis, 2022-10-28)Bakgrunn: Omkring åtte prosent av verdens nyfødte har behov for pustehjelp for å klare overgangen fra intra- til ekstrauterint liv. Nøyaktig forekomst er usikker og varierer antagelig mellom ulike settinger, men resuscitering ... -
A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19
(Journal article; Peer reviewed, 2023)COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ...