Browsing Department of Clinical Science by Title
Now showing items 443-462 of 2348
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Contextual factors influencing medicines-related interventions to support safe transitions for care home residents post hospital discharge: a systematic review and meta-ethnographic synthesis
(Journal article; Peer reviewed, 2022)Background Residents of care or nursing homes are at a higher risk of medication-related harm, especially during care transitions. No medicines-related intervention has been identified that supports the safe transition ... -
Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours: a multicentre retrospective observational cohort study
(Journal article; Peer reviewed, 2022)Background Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence ... -
Continuity of care after percutaneous coronary intervention: The patient's perspective across secondary and primary care settings
(Peer reviewed; Journal article, 2017)Background: Although patients may experience a quick recovery followed by rapid discharge after percutaneous coronary interventions (PCIs), continuity of care from hospital to home can be particularly challenging. Despite ... -
Continuity of care and its associations with self-reported health, clinical characteristics and follow-up services after percutaneous coronary intervention
(Journal article; Peer reviewed, 2020)Aims Complexity of care in patients with coronary artery disease is increasing, due to ageing, improved treatment, and more specialised care. Patients receive care from various healthcare providers in many settings. Still, ... -
Continuous positive airway pressure for bronchiolitis in a general paediatric ward; a feasibility study
(Peer reviewed; Journal article, 2014-05-12)Background: Continuous positive airway pressure (CPAP) is commonly used to relieve respiratory distress in infants with bronchiolitis, but has mostly been studied in an intensive care setting. Our prime aim was to evaluate ... -
Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison’s Disease: A Randomized Clinical Trial
(Peer reviewed; Journal article, 2014)Context: Conventional glucocorticoid replacement therapy fails to mimic the physiological cortisol rhythm, which may have implications for morbidity and mortality in patients with Addison’s disease. Objective: The objective ... -
Contrast stress echocardiography in hypertensive heart disease
(Peer reviewed; Journal article, 2011-11-18)Hypertension is associated with atherosclerosis and cardiac and vascular structural and functional changes. Myocardial ischemia may arise in hypertension independent of coronary artery disease through an interaction between ... -
The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations
(Journal article; Peer reviewed, 2023)Aims/hypothesis: We examined the contribution of rare HNF1A variants to type 2 diabetes risk and age of diagnosis, and the extent to which their impact is affected by overall genetic susceptibility, across three ancestry ... -
Conundrums in the breathless athlete; exercise-induced laryngeal obstruction or asthma?
(Journal article; Peer reviewed, 2022)Purpose: Exercise-induced bronchoconstriction (EIB) and exercise-induced laryngeal obstruction (EILO) are the two disorders commonly considered when athletes complain of exertional dyspnea. They are highly different but ... -
Convergence of virulence and MDR in a single plasmid vector in MDR Klebsiella pneumoniae ST15
(Peer reviewed; Journal article, 2019)Background: MDR and hypervirulence (hv) are typically observed in separate Klebsiella pneumoniae populations. However, convergent strains with both properties have been documented and potentially pose a high risk to public ... -
Coordination of Metabolism and Virulence Factors Expression of Extraintestinal Pathogenic Escherichia coli Purified from Blood Cultures of Patients with Sepsis
(Peer reviewed; Journal article, 2016-09)One of the trademarks of extraintestinal pathogenic Escherichia coli is adaptation of metabolism and basic physiology to diverse host sites. However, little is known how this common human pathogen adapts to permit survival ... -
COPD - do the right thing
(Journal article; Peer reviewed, 2021)A gap exists between guidelines and real-world clinical practice for the management and treatment of chronic obstructive pulmonary disease (COPD). Although this has narrowed in the last decade, there is room for improvement ... -
Coping with a disruptive life caused by obstetric fistula: Perspectives from Malawian women
(Peer reviewed; Journal article, 2019)Background: The main symptom of obstetric fistula is urinary and or fecal incontinence. Incontinence, regardless of the type is debilitating, socially isolating, and psychologically depressing. The objective of this study ... -
Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD
(Journal article; Peer reviewed, 2020)Patients diagnosed with chromosome microdeletions or duplications, known as copy number variants (CNVs), present a unique opportunity to investigate the relationship between patient genotype and cell phenotype. CNVs have ... -
The core clock transcription factor BMAL1 drives circadian β-cell proliferation during compensatory regeneration of the endocrine pancreas
(Journal article; Peer reviewed, 2020)Circadian clocks in pancreatic islets participate in the regulation of glucose homeostasis. Here we examined the role of these timekeepers in β-cell regeneration after the massive ablation of β cells by doxycycline-induced ... -
Correlating local and systemic tumor-associated inflammation in colon cancer : CRP and the tumor immune microenvironment
(Doctoral thesis, 2023-12-14)Bakgrunn: Markører for systemisk inflammasjon er assosiert med dårlig prognose i en rekke ulike kreft typer, inkludert tykk- og endetarms kreft (CRC). I dette prosjektet fokuseres på betydningen av systemisk tumor-assosiert ... -
Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables
(BMC Bioinformatics 7(198), Peer reviewed; Journal article, 2006-04-10)Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique to examine post-translational modifications of complexly modulated proteins. Currently, spot detection is a necessary step to assess relations ... -
Correlation between Murmurs and Echocardiographic Findings; From an Imaging Cardiologist Point of View
(Journal article; Peer reviewed, 2023)A heart murmur in adults is a common reason for referral for echocardiography at most general cardiology clinics in Europe. A murmur may indicate either a mild age-related valvular calcification or regurgitation, or represent ... -
Cortical thickness changes after computerized working memory training in patients with mild cognitive impairment
(Journal article; Peer reviewed, 2022-04-04)Background: Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related ... -
Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation
(Journal article; Peer reviewed, 2022)Objectives To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, and the impact of dexamethasone as standard therapy. Methods This multicentre, observational, ...