Browsing Department of Clinical Science by Title
Now showing items 537-556 of 2348
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Development of lung diffusion to adulthood following extremely preterm birth
(Journal article; Peer reviewed, 2022)Background: Gas exchange in extremely preterm (EP) infants must take place in fetal lungs. Childhood lung diffusing capacity of the lung for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been ... -
Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma
(Journal article; Peer reviewed, 2020-02-10)Background In endometrioid endometrial cancer (EEC), current clinical algorithms do not accurately predict patients with lymph node metastasis (LNM), leading to both under- and over-treatment. We aimed to develop models ... -
Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension
(Journal article; Peer reviewed, 2022)We developed three ultra-high pressure liquid chromatography coupled to mass spectrometry detection (UHPLC-MS/MS) methods to quantify 25 antihypertensive drugs in serum samples. Patient-reported drug lists were collected, ... -
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
(Journal article; Peer reviewed, 2021)Dihydroorotate dehydrogenase (DHODH) is essential for the de novo synthesis of pyrimidine ribonucleotides, and as such, its inhibitors have been long used to treat autoimmune diseases and are in clinical trials for cancer ... -
Diabetes mellitus impact on fetal liver circulation, and new diagnostic options
(Journal article; Peer reviewed, 2023)While biometry and Doppler have proved useful in the management of fetal growth restriction, the same battery has been of less help in diabetic pregnancies. It is not surprising since the underlying pathophysiology is ... -
Diabetes mellitus type 2; The incretin effect and interaction with the autonomic nervous system
(Doctoral thesis, 2023-09-22)Bakgrunn: Inkretineffekten er kroppens evne til økt insulinsekresjon når glukose inntas peroralt sammenliknet med administrert intravenøst, utløst av spesifikke hormoner fra tarmen. En redusert inkretineffekt leder til ... -
Diagnosing pediatric malaria in Dar es Salaam, Tanzania. Clinical and laboratorial perspectives
(Doctoral thesis, 2014-05-20)Malaria is an extensive global health issue with high morbidity and mortality. Diagnostics of malaria are challenging. Clinically malaria is indistinguishable from various other infectious diseases. Microscopy of blood ... -
Diagnosis and follow-up of treatment of latent tuberculosis; the utility of the QuantiFERON-TB Gold In-tube assay in outpatients from a tuberculosis low-endemic country
(Peer reviewed; Journal article, 2010-03-08)Background Interferon-gamma (IFN-γ) Release Assays (IGRA) are more specific than the tuberculosis skin test (TST) in the diagnosis of latent tuberculosis (TB) infection (LTBI). We present the performance of the QuantiFERON®-TB ... -
Diagnostic accuracy of liquid biopsy in endometrial cancer
(Journal article; Peer reviewed, 2021)Background: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in ... -
Diagnostic stewardship aiming at expectorated or induced sputum promotes microbial diagnosis in community-acquired pneumonia
(Journal article; Peer reviewed, 2022)Purpose: Studies on aetiology of community-acquired pneumonia (CAP) vary in terms of microbial sampling methods, anatomical locations, and laboratory analyses, since no gold standard exists. In this large, multicentre, ... -
Diagnostic testing of autonomous cortisol secretion in adrenal incidentalomas
(Journal article; Peer reviewed, 2020)Objective: Autonomous cortisol secretion (ACS) is a condition with ACTH-independent cortisol overproduction from adrenal incidentalomas (AI) or adrenal hyperplasia. The hypercortisolism is often mild, and most patients ... -
The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing
(Journal article; Peer reviewed, 2023)This prospective study assessed the value of initial microscopy evaluation of sputum samples submitted for rapid syndromic PCR-based testing. Bacterial detections by the BioFire FilmArray Pneumonia Panel plus in 126 high- ... -
Diagnostic validity of fatal cerebral strokes and coronary deaths
(Peer reviewed; Journal article, 2011-03)Mortality statistics represent important endpoints in epidemiological studies. The diagnostic validity of cerebral stroke and ischemic heart disease recorded as the underlying cause of death in Norwegian mortality statistics ... -
Diagnostikk og behandling av autoimmun hepatitt
(Journal article; Peer reviewed, 2021)Autoimmun hepatitt er en kronisk leversykdom som ubehandlet kan føre til levercirrhose og leversvikt. Majoriteten av pasientene responderer godt på standard immunsuppressiv behandling, men noen opplever bivirkninger eller ... -
Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat
(Peer reviewed; Journal article, 2014-05-27)Aim: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate ... -
Diet and effects of diet management on symptoms and quality of life in patients with irritable bowel syndrome
(Master thesis, 2011-05-16)Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder manifested by abdominal discomfort or pain, bloating and abdominal distension, and changes in the defecation pattern between diarrhoea and constipation. ... -
Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study
(Peer reviewed; Journal article, 2013-10-08)Background: A beneficial effect of a high n-3 long-chain polyunsaturated fatty acid (LCPUFA) intake has been observed in heart failure patients, who are frequently insulin resistant. We investigated the potential influence ... -
Dietary linoleic acid induces obesity through excessive endocannabinoid activity
(Doctoral thesis, 2012-03-23)Background: Dietary intakes of the n-6 fatty acid linoleic acid (LA, 18:2n-6) have increased dramatically during the 20th century. Replacing fish oil (FO) with vegetable oil (VO) in feed for farmed fish introduces LA and ... -
Dietary predictors of bone mineral density, hip fractures, mobility and muscle strength - in community-dwelling older persons
(Doctoral thesis, 2018-10-23)Background: The aging process involves decline of both muscle and bone mass. The loss of muscle mass is associated with decreased muscle strength and mobility, while loss of bone mass leads to osteoporosis and increased ... -
Dietary RNA (s. Cerevisiae) stimulated cytokine secretion in human immune cells: involvement of p38 MAPK, and co-stimulation with LPS or PHA
(Master thesis, 2009-07-01)Dietary nucleotides and nucleic acids are known to affect immune functions in animals and humans, both in vitro and in vivo. In this thesis I wanted to investigate the effect of dietary RNA from baker’s yeast on cytokine ...