Blar i Department of Clinical Science på tittel
Viser treff 1674-1693 av 2347
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Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Phenazine 5,10-dioxide analogues as drugs against acute myeloid leukaemia. -Preclinical documentation for lead selection
(Master thesis, 2018-06-29)Background: Acute Myeloid Leukaemia (AML) is a form of cancer that is associated with low survival rates, and where the current treatment is impaired by low tolerance and severe side-effects. Thus, novel treatments are ... -
Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods
(Journal article; Peer reviewed, 2021)Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ... -
Phenotypic diversity of human adipose tissue-resident NK cells in obesity
(Journal article; Peer reviewed, 2023-02-22)Natural killer (NK) cells have emerged as key mediators of obesity-related adipose tissue inflammation. However, the phenotype of NK cell subsets residing in human adipose tissue are poorly defined, preventing a detailed ... -
The pholcodine Case. Cough Medicines, IgE-Sensitization, and Anaphylaxis: A Devious Connection
(Peer reviewed; Journal article, 2012-07-15)The Scandinavian data on pholcodine (PHO) strongly indicates that there is a biological chain from PHO exposure through IgE-sensitization to IgE-mediated anaphylaxis to neuromuscular blocking agents (NMBA). PHO is probably ... -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
(Peer reviewed; Journal article, 2015-09-08)Seafood is assumed to be beneficial for cardiovascular health, mainly based on plasma lipid lowering and anti-inflammatory effects of n-3 polyunsaturated fatty acids. However, other plasma risk factors linked to cardiovascular ... -
A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats
(Peer reviewed; Journal article, 2015-07-16)Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have ... -
Phospholipids from herring roe improve plasma lipids and glucose tolerance in healthy, young adults
(Peer reviewed; Journal article, 2014-05-17)Background: Herring roe is an underutilized source of n-3 polyunsaturated fatty acids (PUFAs) for human consumption with high phospholipid (PL) content. Studies have shown that PL may improve bioavailability of n-3 PUFAs. ... -
Physical activity and exercise capacity in survivors of preterm birth : A population-based cohort study of long-term consequences of prematurity
(Doctoral thesis, 2022-05-19)Background: Physical activity (PA) is an important mediator of health. Extremely preterm (EP) (<28 weeks’ gestation) and extremely low birth weight (ELBW) (<1000 g) subjects are at increased risk of long-term sequelae that ... -
Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment
(Journal article; Peer reviewed, 2022)Background Physical activity (PA) influences sympathetic stimulation, platelet activation as well as vascular function, and has been associated with improved health outcomes in patients with coronary heart disease. β-blocker ... -
Physical activity, exercise and cardiac troponins: Clinical implications
(Peer reviewed; Journal article, 2019)Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are ... -
Physical and cognitive performance after blood donation : A clinical study to investigate donor safety in walking blood banks
(Doctoral thesis, 2023-06-13)De siste 20 årene har fullblod til pasienter i blødningssjokk blitt re-lansert som foretrukket behandling. I vandrende blodbanker blir blodet oppbevart i original forpakningen inntil behovet oppstår. Konseptet har logistiske ... -
Physiotherapy improves symptoms of exercise-induced laryngeal obstruction in young elite athletes: A case series
(Peer reviewed; Journal article, 2019)Objective: A constricted, upper chest breathing pattern and postural dealignments habitually accompany exercise-induced laryngeal obstruction (EILO), but there are few effective treatments for athletes presenting with EILO. ... -
Phytochemical Observations on European Mistletoe (Viscum album L.)
(Master thesis, 2009-06-12)Non-polar constituents were extracted from Viscum album with hexane, by Soxhlet extraction. The extract was analysed by gas chromatography - mass spectrometry, and the following fatty acids, methyl esters and triterpenes ... -
Phytochemicals as a Source of Novel Drugs Against Prostate Cancer - Preparation of Animal Experiments and Isolation and Identification of Flavonoid Glycosides from Abies pindrow
(Master thesis, 2012-05-21)Introduction: Plants and herbs have been utilized for centuries by traditional medicinal systems (e.g. TCM, Ayurveda) to alleviate minor illnesses and major diseases. In recent decades, interest in traditional medicine has ... -
The PI3K-Akt-mTOR intracellular signaling pathway in human acute myeloid leukemia
(Doctoral thesis, 2019-03-08)Acute myeloid leukemia (AML) is a heterogeneous malignancy where disruption of normal intracellular signaling occurs due to mutations or abnormal external signaling. Many pathways have emerged as potential targets for ... -
The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells
(Journal article; Peer reviewed, 2020)Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell growth is characterized by disruption of normal ... -
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer
(Peer reviewed; Journal article, 2017-08-31)Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship ... -
PIK3CA mutations and their impact on survival outcomes of patients with endometrial cancer: A systematic review and meta-analysis
(Journal article; Peer reviewed, 2023-03-21)Several studies have highlighted the frequent alterations of the PI3K pathway in endometrial cancer leading to increased signaling activation with potential for targeted treatment. The objective of this meta-study was to ... -
A Pilot Evaluation of p53 Activating Therapy as a Novel Strategy in the Treatment of Acute Myeloid Leukaemia
(Master thesis, 2008-06-08)p53 is a tumour suppressor protein involved in maintenance of genomic stability of the cell. Primarily, p53 protects the cell from malignant transformation through cell cycle arrest and apoptosis. While mutations in p53 ...