Blar i Department of Clinical Science på tittel
Viser treff 1213-1232 av 2348
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Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats
(Peer reviewed; Journal article, 2018-06-28)Increasing evidence indicates that lean fish consumption may benefit cardiovascular health. High cholesterol and low n-3 PUFA concentrations in serum are associated with an increased risk of coronary heart disease; therefore, ... -
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance
(Journal article; Peer reviewed, 2022)Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological ... -
Integrated analysis of robust sex-biased gene signatures in human brain
(Journal article; Peer reviewed, 2023)Background: Sexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the species. Accordingly, the fundamental social and cultural stratification ... -
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
(Peer reviewed; Journal article, 2010-07-09)Background Several observations suggest that immunological events early after chemotherapy, possibly during the period of severe treatment-induced cytopenia, are important for antileukemic immune reactivity in acute myeloid ... -
Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: Results from the European Community Respiratory Health Survey
(Peer reviewed; Journal article, 2014)Background: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory symptoms and reduced lung ... -
Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial
(Peer reviewed; Journal article, 2012)Objectives Fatigue is a major cause of disability in primary Sjögren's syndrome (pSS). Fatigue has similarities with sickness behaviour in animals; the latter mediated by pro-inflammatory cytokines, in particular interleukin ... -
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
(Journal article; Peer reviewed, 2019)Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide ... -
Interleukin-18 signaling system links to agitation in severe mental disorders
(Journal article; Peer reviewed, 2022)Objective Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to severe mental disorders and ... -
Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome
(Doctoral thesis, 2021-12-14)The cytokine interleukin-2 (IL-2) acts as a double-edged sword by promoting both immunity and immune tolerance. Regulatory T cells (Tregs) are responsible for maintaining self-tolerance and constitutively express the high ... -
Interleukin-6 in allogeneic stem cell transplantation: Its possible importance for immunoregulation and as a therapeutic target
(Peer reviewed; Journal article, 2017-06-08)Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and ... -
Intermediate care in nursing home after hospital admission: a randomized controlled trial with one year follow-up
(Peer reviewed; Journal article, 2014-12-09)Background: Intermediate care is intended to reduce hospital admissions and facilitate early discharge. In Norway, a model was developed with transfer to intermediate care shortly after hospital admission. Efficacy and ... -
International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): Rationale for and design of a global registry
(Peer reviewed; Journal article, 2015-03-10)Aims. The clinical characteristics, initial presentation, management, and outcomes of patients hospitalized with new-onset (first diagnosis) heart failure (HF) or decompensation of chronic HF are poorly understood worldwide. ... -
Internet marketing of the herbal product ginger for use against nausea and vomiting
(Master thesis, 2010-05-16)Aim: The purpose of the study was to evaluate Internet marketing of ginger for use against nausea and vomiting during pregnancy (NVP) with particular focus on claims related to safety and efficacy in this indication. Method: ... -
Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability
(Journal article; Peer reviewed, 2023)Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes ... -
The Interplay Between Prostate Cancer Genomics, Metabolism, and the Epigenome: Perspectives and Future Prospects
(Journal article; Peer reviewed, 2021)Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the ... -
Interrelationships between anthropometric variables and overweight in childhood and adolescence
(Peer reviewed; Journal article, 2014-04-30)Objectives To answer the questions: how does body mass index (BMI) correlate to five overweight related anthropometric variables during different ages in childhood, and which anthropometric variables contribute most to ... -
Interstitial changes in spleen during sepsis
(Conference poster, 2014-09-26) -
Intestinal fermentation in patients with self-reported food hypersensitivity: painful, but protective?
(Peer reviewed; Journal article, 2010-07-03)Purpose: Enterometabolic disturbances may cause meal-related symptoms. We performed a functional evaluation of the intestinal microflora in patients with unexplained, self-reported food hypersensitivity by measuring fecal ... -
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
(Peer reviewed; Journal article, 2015-01-27)Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, ...