Blar i Department of Clinical Science på tittel

Viser treff 1405-1424 av 2346

    • Measurement of left ventricular deformation using 3D echocardiography 

      Hjertaas, Johannes Just (Doctoral thesis, 2023-06-05)
      Bakgrunn: 3D speckle tracking ekkokardiografi (STE) er en hjerteultralydmetode som gir mulighet for måling av deformasjonsparametere, som strain, rotasjon, tvist og torsjon. Den største begrensningen for 3D STE er lav tids- ...

    • Measures of symmetry in gait. Methodological principles and clinical choices 

      Hodt-Billington, Caroline (Doctoral thesis, 2012-02-24)
      The aim of this thesis is to evaluate measures of gait symmetry in subjects with disease or injury related to one-sided affection. This thesis also aims to relate objective measures of gait quality (gait symmetry) to other ...

    • Measuring discharge care quality in hospitalised elderly: Development and validation of an instrument based on patients’ experiences 

      Boge, Ranveig Marie (Doctoral thesis, 2020-03-20)
      Background: Elderly patients account for a majority of hospital admissions. Their wellbeing and safety are at risk in the discharge process due to quality deficiencies, thus, accurate and vigorous instruments to monitor ...

    • Measuring discharge quality based on elderly patients’ experiences with discharge conversation: a cross-sectional study 

      Boge, Ranveig Marie; Haugen, Arvid Steinar; Nilsen, Roy Miodini; Bruvik, Frøydis Kristine; Harthug, Stig (Peer reviewed; Journal article, 2019)
      Background: Discharge conversation is an essential part of preparing patients for the period after hospitalisation. Successful communication during such conversations is associated with improved health outcomes for patients. ...

    • Mechanical assist in cardiac arrest: Optimising circulatory support. Experimental studies. 

      Packer, Erik J. S. (Doctoral thesis, 2022-03-30)
      Introduction: Mechanical circulatory support (MCS) may be useful in cardiac arrest (CA), both in- and out- of hospital. However, efficacy and survival benefit has been difficult to evaluate compared to standard cardiopulmonary ...

    • Mechanical behavior and collagen structure of degenerative mitral valve leaflets and a finite element model of primary mitral regurgitation 

      Sadeghinia, Mohammadjavad; Aguilera, Hans Martin Dahl; Urheim, Stig; Persson, Robert; Ellensen, Vegard Skalstad; Haaverstad, Rune; Holzapfel, Gerhard; Skallerud, Bjørn Helge; Prot, Victorien Emile (Journal article; Peer reviewed, 2023)
      Degenerative mitral valve disease is the main cause of primary mitral regurgitation with two phenotypes: fibroelastic deficiency (FED) often with localized myxomatous degeneration and diffuse myxomatous degeneration or ...

    • Medikamentbruk blant ungdommer i Sogn og Fjordane. En samling av tversnittstudier fra 97-09 

      Stien, Trine Høstmark (Master thesis, 2013-05-21)
      Ungdomstiden er en periode i livet preget av mye usikkerhet og tilpasning i forhold til endringene som puberteten medfører. Denne overgangsfasen fra barn til voksen gjør i seg selv ungdommer sårbare, og dersom de i tillegg ...

    • Menopause as a predictor of new-onset asthma 

      Triebner, Kai; Johannessen, Ane; Puggini, Luca; Benediktsdottir, Bryndis; Bertelsen, Randi Jacobsen; Bifulco, Ersilia; Dharmage, Shyamali C.; Franklin, Karl A.; Gislason, Þórarinn; Holm, Mathias; Jarvis, Deborah; Leynaert, Bénédicte; Lindberg, Eva; Macsali, Ferenc; Malinovschi, Andrej; Norbäck, Dan; Omenaas, Ernst; Rodriguez, Francisco J; Saure, Eirunn Waatevik; Schlünssen, Vivi; Sigsgaard, Torben; Skorge, Trude Duelien; Wieslander, Gunilla; Zemp, Elisabeth; Svanes, Cecilie; Hustad, Simon Steinar; Gomez Real, Francisco (Peer reviewed; Journal article, 2015-01)
      Background: There is limited and conflicting evidence on the effect of menopause on asthma. Objectives: We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal ...

    • Merkevaren apotek før og nå 

      Lawther, Susanna Kathleen (Master thesis, 2023-01-03)

    • Mesenchymal stem cells support survival and proliferation of primary human acute myeloid leukemia cells through heterogeneous molecular mechanisms 

      Brenner, Annette; Nepstad, Ina; Bruserud, Øystein (Peer reviewed; Journal article, 2017-02-09)
      Acute myeloid leukemia (AML) is a bone marrow malignancy, and various bone marrow stromal cells seem to support leukemogenesis, including osteoblasts and endothelial cells. We have investigated how normal bone marrow ...

    • Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 

      Cheng, Timothy H.T.; Thompson, Deborah; Painter, Jodie; Omara, Tracy; Gorman, Maggie; Martin, Lynn; Palles, Claire; Jones, Angela; Buchanan, Daniel D.; Ko Win, Aung; Hopper, John; Jenkins, Mark; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steve; Conti, David; Schumacher, Fred; Casey, Graham; Giles, Graham G.; Pharoah, Paul; Peto, Julian; Cox, Angela; Swerdlow, Anthony; Couch, Fergus; Cunningham, Julie M.; Goode, Ellen L.; Winham, Stacey J.; Lambrechts, Diether; Fasching, Peter; Burwinkel, Barbara; Brenner, Hermann; Brauch, Hiltrud; Chang-Claude, Jenny; Salvesen, Helga Birgitte; Kristensen, Vessela N.; Darabi, Hatef; Li, Jingmei; Liu, Tao; Lindblom, Annika; Hall, Per; De Polanco, Magdalena Echeverry; Sans, Monica; Carracedo, Angel; Castellvi-Bel, Sergi; Rojas-Martinez, Augusto; Aguiar Jnr, Samuel; Teixeira, Manuel R.; Dunning, Alison M.; Dennis, Joe; Otton, Geoffrey; Proietto, Tony; Holliday, Elizabeth; Attia, John; Ashton, Katie; Scott, Rodney J.; McEvoy, Mark; Dowdy, Sean C.; Fridley, Brooke L.; Werner, Henrica Maria Johanna; Trovik, Jone; Njølstad, Tormund Salvesen; Tham, Emma; Mints, Miriam; Runnebaum, Ingo; Hillemanns, Peter; Dörk, Thilo; Amant, Frederic; Schrauwen, Stefanie; Hein, Alexander; Beckmann, Matthias W.; Ekici, Arif; Czene, Kamila; Meindl, Alfons; Bolla, Manjeet K.; Michailidou, Kyriaki; Tyrer, Jonathan P.; Wang, Qin; Ahmed, Shahana; Healey, Catherine S.; Shah, Mitul; Annibali, Daniela; Depreeuw, Jeroen; Al-Tassan, Nada A.; Harris, Rebecca; Meyer, Brian F; Whiffin, Nicola; Hosking, Fay J.; Kinnersley, Ben; Farrington, Susan M; Timofeeva, Maria; Tenesa, Albert; Campbell, Harry; Haile, Robert W.; Hodgson, Shirley; Carvajal-Carmona, Luis; Cheadle, Jeremy P.; Easton, Douglas; Dunlop, Malcolm; Houlston, Richard; Spurdle, Amanda; Tomlinson, Ian (Peer reviewed; Journal article, 2015-12-01)
      High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using ...

    • Metabolic and Epigenetic Regulation by Estrogen in Adipocytes 

      Bjune, Jan-Inge; Strømland, Pouda Panahandeh; Jersin, Regine Åsen; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022-02-22)
      Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ...

    • Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders 

      Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2020)
      Background: We aimed at exploring potential pathophysiological processes across psychotic disorders, applying metabolomics in a large and well-characterized sample of patients and healthy controls. Methods: Patients with ...

    • Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2015-12)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, but ...

    • Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers 

      Gloyn, Anna L.; Faber, Johan H.; Malmodin, Daniel; Thanabalasingham, Gaya; Lam, Francis; Ueland, Per Magne (Peer reviewed; Journal article, 2012-07-30)
      It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ...

    • Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease 

      Bjune, Mona Synnøve; Dyer, Laurence; Laupsa-Borge, Johnny; Sommersten, Cathrine Horn; McCann, Adrian; Glastad, Robert Clay; Johnston, Iain; Kern, Matthias; Blüher, Matthias; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2023)
      Background: The valine (branched-chain amino acid) metabolite 3-hydroxyisobutyrate (3-HIB), produced by 3-Hydroxyisobutyryl-CoA Hydrolase (HIBCH), is associated with insulin resistance and type 2 diabetes, but implicated ...

    • Metabolic serum profiles for patients receiving allogeneic stem cell transplantation: the pretransplant profile differs for patients with and without posttransplant capillary leak syndrome 

      Reikvam, Håkon; Grønningsæter, Ida-Sofie; Ahmed, Aymen B; Hatfield, Kimberley Joanne; Bruserud, Øystein (Peer reviewed; Journal article, 2015-12)
      Allogeneic stem cell transplantation is commonly used in the treatment of younger patients with severe hematological diseases, and endothelial cells seem to be important for the development of several posttransplant ...

    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...

    • Metformin exposure, maternal PCOS status and fetal venous liver circulation: A randomized, placebo-controlled study 

      Grindheim, Sindre; Ebbing, Cathrine; Karlsen, Henriette Odland; Skulstad, Svein Magne; Real, Francisco Gomez; Lønnebotn, Marianne; Løvvik, Tone Shetelig; Vanky, Eszter; Kessler, Jørg (Journal article; Peer reviewed, 2022-01-28)
      Background: Metformin is prescribed to women with polycystic ovary syndrome (PCOS) to prevent pregnancy complications. Children exposed to metformin vs. placebo in utero, have increased head circumference at birth and are ...

    • Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2) 

      Madsen, Andre; Bozickovic, Olivera; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. (Peer reviewed; Journal article, 2015-11-09)
      The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 ...