Blar i Department of Clinical Science på tittel

Viser treff 1425-1444 av 2347

    • Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2) 

      Madsen, Andre; Bozickovic, Olivera; Bjune, Jan Inge; Mellgren, Gunnar; Sagen, Jørn V. (Peer reviewed; Journal article, 2015-11-09)
      The ability of the anti-diabetic drug metformin to inhibit anabolic processes including gluconeogenesis and lipogenesis is partly attributable to activation of the AMP-activated protein kinase (AMPK) pathway. The p160 ...

    • Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment 

      Petakh, Pavlo; Kamyshna, Iryna; Oksenych, Valentyn; Kainov, Denis; Kamyshnyi, Aleksandr (Journal article; Peer reviewed, 2023)
      The gut microbiota play a crucial role in maintaining host health and have a significant impact on human health and disease. In this study, we investigated the alpha diversity of gut microbiota in COVID-19 patients and ...

    • Methodological issues in airway microbiome studies 

      Drengenes, Christine (Doctoral thesis, 2020-12-04)
      Background Studies on the lung microbiome face unique methodological challenges tied to the low bacterial load of acquired samples and the increased susceptibility to bacterial DNA contamination. Contamination may be ...

    • Meticillinresistente gule stafylokokker i sårsekret hos barn 

      Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus Andreas (Journal article; Peer reviewed, 2022)
      BAKGRUNN Hud- og bløtvevsinfeksjoner er vanlig hos barn. Vi ønsket å undersøke forekomsten av meticillinresistens blant gule stafylokokker i sårsekret fra barn i Norge. MATERIALE OG METODE Vi gjennomførte en ...

    • Metric based virtual simulation training for endovascular thrombectomy improves interventional neuroradiologists’ simulator performance 

      Schneider, Magnus Sundgot; Sandve, Knut Olav Lende; Kurz, Kathinka Dæhli; Dalen, Ingvild; Ospel, Johanna; Goyal, Mayank; Kurz, Friedrich Martin Wilhelm; Fjetland, Lars (Journal article; Peer reviewed, 2022)
      Objective Metric based virtual reality simulation training may enhance the capability of interventional neuroradiologists (INR) to perform endovascular thrombectomy. As pilot for a national simulation study we examined ...

    • Metronidazole-sensitive organisms in children with severe acute malnutrition: an evaluation of the indication for empiric metronidazole treatment 

      Zangenberg, Mike; Abdissa, Alemseged; Johansen, Øystein Haarklau; Tesfaw, Getnet; Girma, Tsinuel; Kurtzhals, Jørgen Anders Lindholm (Peer reviewed; Journal article, 2020)
      Objectives: Children with severe acute malnutrition (SAM) are treated with empiric amoxicillin or penicillin and gentamicin because of the high risk of severe infections. Experts have suggested, based on available evidence, ...

    • The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1 

      Tosi, Giovanna; Forlani, Greta; Andresen, Vibeke; Turci, Marco; Bertazzoni, Umberto; Franchini, Genoveffa; Accolla, Roberto S. (Conference lecture, 2011-06-06)

    • Microbiological and bioinformatics analysis of primary Sjogren's syndrome patients with normal salivation 

      Siddiqui, Huma; Chen, Tsute; Aliko, Ardita; Mydel, Piotr Mateusz; Jonsson, Roland; Olsen, Ingar (Peer reviewed; Journal article, 2016-10-20)
      Background: Reduced salivation is considered a major clinical feature of most but not all cases of primary Sjögren’s syndrome (pSS). Reduced saliva flow may lead to changes in the salivary microbiota. These changes have ...

    • Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function 

      Gao, Jie; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2021)
      Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ...

    • Micronutrients in paediatric Intestinal Failure Patients receiving home parenteral nutrition 

      Thomassen, Rut Anne; Kvammen, Janne Anita; Sæland, Camilla; Kjeserud, Christina; Eikeland, Joakim; Juliusson, Petur Benedikt; Bentsen, Beint Sigmund; Henriksen, Christine (Journal article; Peer reviewed, 2020-11)
      Background & aims Children with intestinal failure (IF) receive parental nutrition to ensure adequate growth and development. The aim of this study was to assess micronutrient status in paediatric IF patients receiving ...

    • A MicroRNA Linking Human Positive Selection and Metabolic Disorders 

      Wang, Lifeng; Sinnott-Armstrong, Nicholas A; Wagschal, Alexandre; Wark, Abigail R.; Camporez, Joao-Paulo; Perry, Rachel J.; Ji, Fei; Sohn, Yoojin; Oh, Justin; Wu, Su; Chery, Jessica; Moud, Bahareh Nemati; Saadat, Alham; Dankel, Simon N; Mellgren, Gunnar; Tallapragada, Divya Sri Priyanka; Strobel, Sophie Madlen; Lee, Mi-Jeong; Tewhey, Ryan; Sabeti, Pardis C.; Schaefer, Anne; Petri, Andreas; Kauppinen, Sakari; Chung, Raymond T.; Soukas, Alexander; Avruch, Joseph; Fried, Susan K.; Hauner, Hans; Sadreyev, Ruslan I.; Shulman, Gerald I.; Claussnitzer, Melina; Näär, Anders M. (Journal article; Peer reviewed, 2020)
      Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also ...

    • MicroRNA serum profiles and chronic graft-versus-host disease 

      Reikvam, Håkon; Vo, Anh Khoi; Johansen, Silje; Hemsing, Anette Lodvir; Haugland Solheim, Magne; Mosevoll, Knut Anders; Tvedt, Tor Henrik Anderson; Hatfield, Kimberley Joanne (Journal article; Peer reviewed, 2022)
      Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During the last decade, the interest of micro RNAs (miRNAs) in the ...

    • MicroRNAs enrichment in GWAS of complex human phenotypes 

      Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, AJ; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas; Djurovic, Srdjan (Peer reviewed; Journal article, 2015-04-16)
      Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ...

    • miR-486-5p expression is regulated by DNA methylation in osteosarcoma 

      Namløs, Heidi Maria; Skårn, Magne Nordang; Ali, Deeqa Ahmed Mohamed; Grad, Iwona; Andresen, Kim; Kresse, Stine Henrichson; Munthe, Else; Serra, Massimo; Scotlandi, Katia; Llombart-Bosch, Antonio; Myklebost, Ola; Lind, Guro Elisabeth; Meza, Leonardo Zepeda (Journal article; Peer reviewed, 2022)
      Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown ...

    • Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value 

      Berg, Hege Fredriksen; Engerud, Hilde Renate; Myrvold, Madeleine; Lien, Hilde Eide; Hjelmeland, Marta Espevold; Halle, Mari Kyllesø; Woie, Kathrine; Høivik, Erling Andre; Haldorsen, Ingfrid S.; Vintermyr, Olav Karsten; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2022)
      Background The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples and investigate the prognostic ...

    • A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats 

      Lindquist, Carine; Bjørndal, Bodil; Bakke, Hege Gilbø; Slettom, Grete; Karoliussen, Marie; Rustan, Arild; Thoresen, G. Hege; Skorve, Jon; Nygård, Ottar; Berge, Rolf Kristian (Peer reviewed; Journal article, 2019-09-24)
      A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine ...

    • Mitral annular dynamics are influenced by left ventricular load and contractility in an acute animal model 

      Persson, Robert Matongo; Aguilera, Hans Martin Dahl; Kvitting, Jon Peder Escobar; Grong, Ketil; Prot, Victorien Emile; Salminen, Pirjo-Riitta; Svenheim, Bård; Leiknes, Anita; Stangeland, Lodve; Haaverstad, Rune; Urheim, Stig (Journal article; Peer reviewed, 2023)
      The purpose of this study was to investigate the effects of loading conditions and left ventricular (LV) contractility on mitral annular dynamics. In 10 anesthetized pigs, eight piezoelectric transducers were implanted ...

    • Mixed Effect Modeling of Dose and Linear Energy Transfer Correlations With Brain Image Changes After Intensity Modulated Proton Therapy for Skull Base Head and Neck Cancer 

      Engeseth, Grete May; He, Renjie; Mirkovic, Dragan; Yepes, Pablo; Mohamed, Abdallah Sherif Radwan; Stieb, Sonja; Fuller, Clifton Dave; Wu, Richard; Zhang, Xiadong; Hysing, Liv Bolstad; Pettersen, Helge Egil Seime; Stokkevåg, Camilla Hanquist; Mohan, Radhe; Frank, Steven Jay; Gunn, Gary Brandon (Journal article; Peer reviewed, 2021)
      Purpose Intensity modulated proton therapy (IMPT) could yield high linear energy transfer (LET) in critical structures and increased biological effect. For head and neck cancers at the skull base this could potentially ...

    • Modeling assortative mating and genetic similarities between partners, siblings, and in-laws 

      Torvik, Fartein Ask; Eilertsen, Espen Moen; Hannigan, Laurie J.; Cheesman, Rosa; Howe, Laurence J.; Magnus, Per Minor; Reichborn-Kjennerud, Ted; Andreassen, Ole A.; Njølstad, Pål Rasmus; Havdahl, Alexandra; Ystrøm, Eivind (Journal article; Peer reviewed, 2022)
      Assortative mating on heritable traits can have implications for the genetic resemblance between siblings and in-laws in succeeding generations. We studied polygenic scores and phenotypic data from pairs of partners ...

    • Modeling psychiatric disorders: From genomic findings to cellular phenotypes 

      Falk, Anna; Heine, Vivi M.; Harwood, Adrian J.; Sullivan, Patrick F.; Peitz, Michael; Brüstle, Oliver; Shen, Sanbring; Sun, Yuh-Man; Glover, Joel; Posthuma, Daniëlle; Djurovic, Srdjan (Peer reviewed; Journal article, 2016)
      Major programs in psychiatric genetics have identified >150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly ...