Blar i Department of Clinical Science på tittel
Viser treff 1445-1464 av 2348
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Modes of e-Health delivery in secondary prevention programmes for patients with coronary artery disease: A systematic review
(Peer reviewed; Journal article, 2019-06-10)Background: Electronic health (e-Health) interventions are emerging as an effective alternative model for improving secondary prevention of coronary artery disease (CAD). The aim of this study was to describe the effectiveness ... -
Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells
(Peer reviewed; Journal article, 2019)Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ... -
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia
(Peer reviewed; Journal article, 2019)Purpose. Valproic acid (VPA) is suggested to be therapeutically beneficial in combination with interferon-alpha (IFNα) in various cancers. Therefore, we examined IFNα and VPA alone and in combinations in selected AML models, ... -
Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A
(Journal article; Peer reviewed, 2023-01-19)Diabetes is a metabolic disease that currently affects nearly half a billion people worldwide. β-cells dysfunction is one of the main causes of diabetes. Exposure to endocrine-disrupting chemicals is correlated with increased ... -
Molecular alterations suggesting new treatment strategies in uterine carcinomas
(Doctoral thesis, 2017-11-10) -
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas
(Journal article; Peer reviewed, 2023)Background: High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain ... -
Molecular Biomarkers in Thyroid Eye Disease: A Literature Review
(Journal article; Peer reviewed, 2023)Purpose: Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves disease. Patients may be severely affected with eyelid retraction, exophthalmos, diplopia, pain, and threatened vision. ... -
Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania
(Journal article; Peer reviewed, 2021)Background We aimed to characterise the genetic determinants and context of two meropenem-resistant clinical isolates of Acinetobacter baumannii isolated from children hospitalised with bloodstream infections in Dar es ... -
The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2021)High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare but have a very poor prognosis and represent a severely understudied class of tumours. Molecular data for HG GEP-NEN are limited, and ... -
Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
(Journal article; Peer reviewed, 2020-01-10)Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ... -
Molecular characterization of antibiotic resistant bacteria in newly HIV diagnosed adults in a community setting in Tanzania. Implications for infection prevention and control in HIV : Antibiotic resistant bacteria, HIV, Community, Sub-Saharan Africa
(Doctoral thesis, 2022-08-26)Mennesker som lever med HIV-infeksjon i utviklingsland har økt risiko for å bli smittet med antibiotikaresistente bakterier. Høyere forbruk av antibiotika på grunn av HIV-relatert sykdom gir et seleksjonspress som kan føre ... -
Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987
(Peer reviewed; Journal article, 2002)In the 1990s, the Newly Independent and Baltic States of the former Soviet Union experienced the largest diphtheria outbreak since the 1960s; it was caused by Corynebacterium diphtheriae strains of a unique clonal group. ... -
Molecular markers to predict prognosis and guide therapy in endometrial cancer
(Doctoral thesis, 2020-02-07)Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
(Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling
(Doctoral thesis, 2020-06-17)Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ... -
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
(Journal article, 2021)Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ... -
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
(Peer reviewed; Journal article, 2014-09-27)Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ... -
Monitoring children and adolescents with severe obesity: body mass index (BMI), BMI z‐score or percentage above the International Obesity Task Force overweight cut‐off?
(Peer reviewed; Journal article, 2019)Aim: Body mass index (BMI) metrics are widely used as a proxy for adiposity in children with severe obesity. The BMI expressed as the percentage of a cut‐off percentile for overweight or obesity has been proposed as a ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
(Peer reviewed; Journal article, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
The monocyte system in haematological malignancies
(Doctoral thesis, 2020-04-17)Monocytes consist of classical, intermediate, and non-classical monocytes. In haematological malignancies, such as multiple myeloma and acute myeloid leukaemia, monocytes are affected by both the disease itself and the ...