Blar i Department of Clinical Science på tittel
Viser treff 1481-1500 av 2343
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Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
(Journal article; Peer reviewed, 2021)Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment response, and minimally invasive disease monitoring. To unlock ... -
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma
(Peer reviewed; Journal article, 2015-08-07)Background: Orthotopic endometrial cancer models provide a unique tool for studies of tumour growth and metastatic spread. Novel preclinical imaging methods also have the potential to quantify functional tumour characteristics ... -
Multimodal imaging of thyroid cancer
(Journal article, 2020)Purpose of review Thyroid cancer is the most common endocrine cancer in adults with rising incidence. Challenges in imaging thyroid cancer are twofold: distinguishing thyroid cancer from benign thyroid nodules, which ... -
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
(Journal article; Peer reviewed, 2022)Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful tools to study brain development and dysfunction. However, whether organoids can functionally connect to a sensory network in vivo has ... -
Multimodality imaging in the immediate and long-term evaluation of bioresorbable vascular scaffolds : In patients with ST-elevation myocardial infarction
(Doctoral thesis, 2024-03-15)Introduksjon Akutt revaskularisering med primær perkutan koronar revaskularisering (PCI) er foretrukne strategi for pasienter med ST-elevasjons myokardielt infarkt (STEMI). Nåværende teknikk er å implantere stenter laget ... -
Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison’s disease
(Peer reviewed; Journal article, 2013)Objective: Liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers superior analytical specificity compared with immunoassays, but it is not available in many regions and hospitals due to expensive instrumentation ... -
The multitude of molecular analyses in cancer: the opening of Pandora’s box
(Peer reviewed; Journal article, 2014-09-03)The availability of large amounts of molecular data of unprecedented depth and width has instigated new paths of interdisciplinary activity in cancer research. Translation of such information to allow its optimal use in ... -
Musculoskeletal Chronic Graft versus Host Disease-A Rare Complication to Allogeneic Hematopoietic Stem Cell Transplant: A Case-Based Report and Review of the Literature
(Journal article; Peer reviewed, 2022)Musculoskeletal graft versus host disease (GVHD) is a rare manifestation of chronic GVHD (cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Left untreated, the disease can cause extensive ... -
Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers
(Journal article; Peer reviewed, 2022)Purpose: The identification of patients with homologous recombination deficiency (HRD) beyond BRCA1/2 mutations is an urgent task, as they may benefit from PARP inhibitors. We have previously developed a method to detect ... -
Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer
(Peer reviewed; Journal article, 2016-01-19)Background: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype ... -
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Clinical trials, medical treatment and pathomechanisms
(Doctoral thesis, 2024-05-02)Myalgisk encefalomyelitt/kronisk utmattelsessyndrom (ME/CFS) er en underprioritert sykdom som rammer 0,2-0,8 % av befolkningen, med ukjent etiologi, høy symptombelastning, ingen biomarkør, og ingen godkjent effektiv ... -
MYC-induced miR-203b-3p and miR-203a-3p control Bcl-xL expression and paclitaxel sensitivity in tumor cells
(Peer reviewed; Journal article, 2018)Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane ... -
The mycobiome in COPD: Descriptive and longitudinal analysis, and participation in research bronchoscopy studies
(Doctoral thesis, 2021-06-25)Background: Chronic obstructive pulmonary disease (COPD) is a high-prevalent lung disease with high mortality rates. The COPD pathogenesis is only partly understood, and we do not know why some risk factor exposed subjects ... -
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction
(Peer reviewed; Journal article, 2012-12-20)Aims: Myocardial CCN2/CTGF is induced in heart failure of various etiologies. However, its role in the pathophysiology of left ventricular (LV) remodeling after myocardial infarction (MI) remains unresolved. The current ... -
Myocardial energy metabolism and ultrastructure with polarizing and depolarizing cardioplegia in a porcine model
(Peer reviewed; Journal article, 2017-03-02)OBJECTIVES: This study investigated whether the novel St. Thomas’ Hospital polarizing cardioplegic solution (STH-POL) with esmolol/adenosine/magnesium offers improved myocardial protection by reducing demands for high-energy ... -
Myocardial function after polarizing versus depolarizing cardiac arrest with blood cardioplegia in a porcine model of cardiopulmonary bypass
(Peer reviewed; Journal article, 2016)OBJECTIVES Potassium-based depolarizing St Thomas' Hospital cardioplegic solution No 2 administered as intermittent, oxygenated blood is considered as a gold standard for myocardial protection during cardiac surgery. ... -
Myocardial function in aortic stenosis - insights from radial multilayer Doppler strain
(Peer reviewed; Journal article, 2015-02-19)Background Left ventricular (LV) radial tissue Doppler imaging (TDI) strain increases gradually from the subepicardial to the subendocardial layer in healthy individuals. A speckle tracking echocardiography study suggested ... -
Myocardial function including estimates of myocardial work in young adults born very preterm or with extremely low birthweight - a cohort study
(Journal article; Peer reviewed, 2023)Background Preterm birth and low birthweight have been associated with increased risk of heart failure and cardiovascular disease in young adulthood. However, results from clinical studies of myocardial function are not ... -
Myocardial injury in a 41-year-old male treated with methylphenidate: a case report
(Peer reviewed; Journal article, 2014-07-29)Background: Elevated cardiac troponin levels are consistent with the diagnosis of an acute coronary syndrome, but may also represent adverse drug reactions. Psychostimulating drugs raise both blood pressure and heart rate, ... -
Myocardial ischemia in non-obstructive coronary artery disease : Associations with coronary artery disease morphology and left ventricular hypertrophy
(Doctoral thesis, 2020-09-22)Background: The underlying mechanisms causing myocardial ischemia in non-obstructive coronary artery disease (CAD) are incompletely understood. We tested whether the total coronary artery plaque burden, coronary tortuosity ...