Blar i Department of Clinical Science på tittel
Viser treff 1655-1674 av 2342
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Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats
(Peer reviewed; Journal article, 2016-01-05)Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ... -
Peroxisome proliferator-activated receptors (PPARs) and mitochondria in relation to lifestyle-related diseases
(Doctoral thesis, 2008-06-17)Obesity is a growing life-style related health problem, and is often accompanied by dyslipidemia, insulin resistance and inflammation. This may in turn lead to hyperinsulinemia, increased risk of non-alcoholic fatty liver ... -
Persistence and Prognostic Implications of Orthostatic Hypotension in Older Individuals with Mild-to-Moderate Dementia
(Peer reviewed; Journal article, 2014)Aim: To study the course and prognostic implications of orthostatic hypotension (OH) in older individuals with mild-to-moderate dementia. Methods: Referrals to outpatient clinics specialising in old age psychiatry and ... -
Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival
(Peer reviewed; Journal article, 2012-08-14)Introduction: Presence of disseminated tumor cells (DTCs) in bone marrow (BM) and circulating tumor cells (CTC) in peripheral blood (PB) predicts reduced survival in early breast cancer. The aim of this study was to determine ... -
Persistent cardiac organ damage in surgically and medically treated primary aldosteronism
(Journal article; Peer reviewed, 2022)Objective: We compared persistent cardiac organ damage in patients treated surgically or medically for primary aldosteronism. Methods: Eighty-four patients (age 57 ± 11 years, 27% women) with primary aldosteronism ... -
Persistent Fever and Positive PCR 90 Days Post-SARS-CoV-2 Infection in a Rituximab-Treated Patient: A Case of Late Antiviral Treatment
(Journal article; Peer reviewed, 2022)Background: Persistent fever after SARS-CoV-2 infection in rituximab-treated patients has been reported. Due to reduced sensitivity in conventional sampling methods and unspecific symptoms in these patients, distinguishing ... -
Persistent pulmonary pathology after COVID‑19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase‑9
(Journal article; Peer reviewed, 2021)The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), ... -
Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype
(Peer reviewed; Journal article, 2012-05-18)Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous condition, the identification of specific clinical phenotypes is key to developing more effective therapies. To explore if the persistence ... -
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
(Journal article; Peer reviewed, 2022)Background: T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown. Objectives: To investigate ... -
Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response
(Journal article; Peer reviewed, 2021)Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 ... -
Personal Cancer Genome Reporter: Variant interpretation report for precision oncology
(Peer reviewed; Journal article, 2018-05)Individual tumor genomes pose a major challenge for clinical interpretation due to their unique sets of acquired mutations. There is a general scarcity of tools that can (i) systematically interrogate cancer genomes in the ... -
Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial
(Journal article; Peer reviewed, 2023)Imipenem/cilastatin/relebactam is approved for the treatment of serious gram-negative bacterial infections in adults. This study assessed the pharmacokinetics (PK), safety, and tolerability of a single dose of imipenem/c ... -
Pharmacokinetics, transcriptional changes and oxidative stress in pink shrimp (Pandalus montagui) exposed to teflubenzuron
(Master thesis, 2017-06-28)In the recent years, infestation with salmon lice has become a major problem in salmonid farms, and has resulted in great economic losses and reduced welfare for farmed salmonids. To enhance the salmon lice combat, there ... -
Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
(Peer reviewed; Journal article, 2019)Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ... -
Pharmacological treatment of Autoimmune Polyendocrine Syndrome type I with Rapamycin, a mTOR inhibitor
(Master thesis, 2020-06-12) -
A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer
(Journal article; Peer reviewed, 2023)Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ... -
Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)Background The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy ... -
Phenazine 5,10-dioxide analogues as drugs against acute myeloid leukaemia. -Preclinical documentation for lead selection
(Master thesis, 2018-06-29)Background: Acute Myeloid Leukaemia (AML) is a form of cancer that is associated with low survival rates, and where the current treatment is impaired by low tolerance and severe side-effects. Thus, novel treatments are ... -
Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods
(Journal article; Peer reviewed, 2021)Improved molecular dissection of the tumor microenvironment (TME) holds promise for treating high-grade serous ovarian cancer (HGSOC), a gynecological malignancy with high mortality. Reliable disease-related biomarkers are ...