Blar i Department of Clinical Science på tittel

Viser treff 1706-1725 av 2348

    • Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study 

      Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ...

    • Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection 

      Berg, Åse; Patel, Sam; Tellevik, Marit Gjerde; Haanshuus, Christel Gill; Dalen, Ingvild; Otterdal, Kari; Ueland, Thor; Moyo, Sabrina John; Aukrust, Pål; Langeland, Nina (Journal article; Peer reviewed, 2020)
      Purpose When considering malaria disease severity, estimation of parasitemia in erythrocytes is important, but sometimes misleading, since the infected erythrocytes may be sequestered in peripheral capillaries. In African ...

    • Plasma protein biomarkers for the detection of pancreatic neuroendocrine tumors and differentiation from small intestinal neuroendocrine tumors 

      Thiis-Evensen, Espen; Kjellman, Magnus; Knigge, Ulrich; Gronbaek, Henning; Schalin-Jäntti, Camilla; Welin, Staffan; Sorbye, Halfdan; del Pilar Schneider, Maria; Belusa, Roger (Journal article; Peer reviewed, 2022)
      There is an unmet need for novel biomarkers to diagnose and monitor patients with neuroendocrine neoplasms. The EXPLAIN study explores a multi-plasma protein and supervised machine learning strategy to improve the diagnosis ...

    • Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation 

      Mikus, Maria Sparreman; Kolmert, Johan; Andersson, Lars I.; Östling, Jörgen; Knowles, Richard G.; Gómez, Cristina; Ericsson, Magnus; Thörngren, John-Olof; Khoonsari, Payam Emami; Dahlén, Barbro; Kupczyk, Maciej; de Meulder, Bertrand; Auffray, Charles; Bakke, Per S.; Beghe, Bianca; Bel, Elisabeth H.; Caruso, Massimo; Chanez, Pascal; Chawes, Bo; Fowler, Stephen J.; Gaga, Mina; Geiser, Thomas; Gjomarkaj, Mark; Horváth, Ildikó; Howarth, Peter H.; Johnston, Sebastian L.; Joos, Guy; Krug, Norbert; Montuschi, Paolo; Musial, Jacek; Niżankowska-Mogilnicka, Ewa; Olsson, Henric K.; Papi, Alberto; Rabe, Klaus F.; Sandström, Thomas; Shaw, Dominick E.; Siafakas, Nikolaos M.; Uhlén, Mathias; Riley, John H.; Bates, Stewart; Middelveld, Roelinde J.M.; Wheelock, Craig E.; Chung, Kian Fan; Adcock, Ian M.; Sterk, Peter J.; Djukanovic, Ratko; Nilsson, Peter; Dahlén, Sven-Erik; James, Anna (Journal article; Peer reviewed, 2022)
      Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised ...

    • Plasma tumour necrosis factor correlates with mRNA expression of tumour necrosis factor and mitochondrial transcription factors in skeletal muscle in patients with chronic heart failure treated with cardiac resynchronization therapy: potential role in myopathy 

      Larsen, Alf Inge; Valborgland, Torstein; Ogne, Christer; Lindal, Sigurd; Halvorsen, Bente; Munk, Peter Scott; Kvaløy, Jan Terje; Aukrust, Pål; Yndestad, Arne (Peer reviewed; Journal article, 2019)
      Chronic heart failure (CHF) is characterized by inflammation and skeletal muscle myopathy, including impaired fibre type distribution and reduced capillary density, reduced cytochrome oxidase activity and reduced mitochondrial ...

    • Plasma-Metanephrines in Patients with Autoimmune Addison’s Disease with and without Residual Adrenocortical Function 

      Åkerman, Anna-Karin; Sævik, Åse Bjorvatn; Thorsby, Per Medbøe; Methlie, Paal; Quinkler, Marcus; Jørgensen, Anders Palmstrøm; Höybye, Charlotte; Debowska, Aleksandra; Nedrebø, Bjørn Gunnar; Dahle, Anne Lise; Carlsen, Siri; Tomkowicz, Aneta; Sollid, Stina Therese; Nermoen, Ingrid; Grønning, Kaja; Dahlqvist, Per; Grimnes, Guri; Skov, Jakob; Finnes, Trine Elisabeth; Wahlberg, Jeanette; Holte, Synnøve Emblem; Simunkova, Katerina; Kämpe, Olle; Husebye, Eystein Sverre; Øksnes, Marianne; Bensing, Sophie (Journal article; Peer reviewed, 2023-05-22)
      Purpose: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison’s disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma ...

    • Platelet functionality in cold-stored whole blood 

      Kristoffersen, Einar Klæboe; Apelseth, Torunn Oveland (Peer reviewed; Journal article, 2019)
      Whole blood is currently being reintroduced as a blood product to be used in massive bleeding situations because it affords plasma, red cells and platelets in a balanced ratio and in a logistical advantageous way. Questions ...

    • Platelet microparticles decrease daunorubicin‐induced dna damage and modulate intrinsic apoptosis in thp‐1 cells 

      Cacic, Daniel; Nordgård, Oddmund; Meyer, Peter Albert; Hervig, Tor (Journal article; Peer reviewed, 2021)
      Platelets can modulate cancer through budding of platelet microparticles (PMPs) that can transfer a plethora of bioactive molecules to cancer cells upon internalization. In acute myelogenous leukemia (AML) this can induce ...

    • Platelet Microparticles Protect Acute Myelogenous Leukemia Cells against Daunorubicin-Induced Apoptosis 

      Cacic, Daniel; Reikvam, Håkon; Nordgård, Oddmund; Meyer, Peter; Hervig, Tor (Journal article; Peer reviewed, 2021)
      The role of platelets in cancer development and progression is increasingly evident, and several platelet–cancer interactions have been discovered, including the uptake of platelet microparticles (PMPs) by cancer cells. ...

    • Platelets for advanced drug delivery in cancer 

      Cacic, Daniel Limi; Hervig, Tor; Reikvam, Håkon (Journal article; Peer reviewed, 2023)
      Introduction: Cancer-related drug expenses are rising with the increasing cancer incidence and cost may represent a severe challenge for drug access for patients with cancer. Consequently, strategies for increasing therapeutic ...

    • Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and Regulated via the MAP Kinase-p38α Signaling Pathway in Gingival Fibroblasts 

      Alim, M. Abdul; Njenda, Duncan; Lundmark, Anna; Kamińska, Marta; Jansson, Leif; Eriksson, Kaja; Kats, Anna; Johannsen, Gunnar; Arvidsson, Catalin Koro; Mydel, Piotr Mateusz; Yucel-Lindberg, Tülay (Journal article; Peer reviewed, 2022)
      Chronic periodontitis (CP) is a bacteria-driven inflammatory disease characterized by the breakdown of gingival tissue, the periodontal ligament, and alveolar bone, leading ultimately to tooth loss. We previously reported ...

    • Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections 

      Dyrhovden, Ruben; Eagan, Tomas Mikal Lind; Fløtten, Øystein; Siljan, William Ward; Leegaard, Truls Michael; Bø, Bjørnar; Fardal, Hilde; Grøvan, Fredrik; Kildahl-Andersen, Arne; Larssen, Kjersti Wik; Tilseth, Rune; Hjetland, Reidar; Løes, Sigbjørn Suk; Lindemark, Frode; Tellevik, Marit Gjerde; Breistein, Rebecca Irene; Kommedal, Øyvind (Journal article; Peer reviewed, 2023)
      Background Many community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such ...

    • PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection 

      Rembeck, Karolina; Maglio, Cristina; Lagging, Martin; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Mørch, Kristine; Buhl, Mads R.; Pedersen, Court; Norkrans, Gunnar; Hellstrand, Kristoffer; Lindh, Magnus; Pirazzi, Carlo; Burza, Maria A.; Romeo, Stefano; Westin, Johan; for the NORDynamIC group (Peer reviewed; Journal article, 2012-09-14)
      Background: Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, has been widely associated with ...

    • Point Shear Wave Elastography and the Effect of Physical Exercise, Alcohol Consumption, and Respiration in Healthy Adults 

      Taraldsen, Victoria; Tomasgard, Sunneva; Rudlang, Margrethe Thune; Gilja, Odd Helge; Vesterhus, Mette; Mjelle, Anders Batman (Journal article; Peer reviewed, 2020)
      Purpose Ultrasound elastography is a noninvasive method for liver stiffness measurement (LSM) with the aim of reflecting approximate liver fibrosis load. Despite minimal evidence, current guidelines recommend 10 min of ...

    • Point-of-care high-sensitivity troponin assays: Advancements, clinical applications, and implementation considerations 

      Thulin, Ingrid Viola Lavesson; Myrmel, Gard Mikael Saele; Jordalen, Silje; Collinson, Paul; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2023)
      High-sensitivity cardiac troponin (hs-cTn) assays have changed the workflow in emergency departments allowing for rapid allocation of patients with high or low risk of non-ST elevation myocardial infarction. Recently, ...

    • Point-of-care influenza testing impacts clinical decision, patient flow and length of stay in hospitalized adults 

      Fjelltveit, Elisabeth Berg; Brokstad, Rebecca Jane Cox; Østensjø, Jørgen; Blomberg, Bjørn; Ebbesen, Marit Helen; Langeland, Nina; Mohn, Kristin Greve Isdahl (Journal article; Peer reviewed, 2022)
      Background Influenza is difficult to distinguish clinically from other acute respiratory infections. Rapid laboratory diagnosis can help initiate early effective antiviral treatment and isolation. Implementing a novel ...

    • Polarizing versus depolarizing blood cardioplegia: An experimental study of myocardial function, metabolism and ultrastructure following cardiopulmonary bypass and cardioplegic arrest 

      Aass, Terje (Doctoral thesis, 2019-01-11)
      In cardiothoracic surgery, the use of the heart-lung machine for cardiopulmonary bypass (CPB) and induced cardiac arrest, cardioplegia, is required for performing the majority of the surgical procedures. Myocardial protection ...

    • Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease 

      Desikan, Rahul S.; Schork, Andrew J.; Wang, Yunpeng; Thompson, Wesley K.; Dehghan, Abbas; Ridker, Paul M.; Chasman, Daniel I.; McEvoy, Linda K.; Holland, Dominic; Chen, Chi-Hua; Karow, David S.; Brewer, James B.; Hess, Christopher P.; Williams, Julie; Sims, Rebecca; O'Donovan, Michael C.; Choi, Seung Hoan; Bis, Joshua C.; Ikram, M. Arfan; Gudnason, Vilmundur; DeStefano, Anita L.; Van Der Lee, Sven J.; Psaty, Bruce M.; Van Duijn, Cornelia M.; Launer, Lenore; Seshadri, Sudha; Pericak-Vance, Margaret A.; Mayeux, Richard; Haines, Jonathan L.; Farrer, Lindsay A.; Hardy, John; Ulstein, Ingun; Aarsland, Dag; Fladby, Tormod; White, Linda; Sando, Sigrid Botne; Rongve, Arvid; Witoelar, Aree; Djurovic, Srdjan; Hyman, Bradley T.; Snædal, Jon; Steinberg, Stacy; Stefansson, Hreinn; Stefánsson, Kári; Schellenberg, Gerard D.; Andreassen, Ole Andreas; Dale, Anders (Peer reviewed; Journal article, 2015-06)
      Background—Epidemiological findings suggest a relationship between Alzheimer disease (AD), inflammation, and dyslipidemia, although the nature of this relationship is not well understood. We investigated whether this ...

    • Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia 

      O'Connell, Kevin Sean; Koch, Elise; Lenk, Hasan Cagin; Akkouh, Ibrahim Ahmed; Hindley, Guy Frederick Lanyon; Jaholkowski, Piotr Pawel; Smith, Robert Løvsletten; Holen, Børge; Shadrin, Alexey; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Steen, Nils Eiel; Dale, Anders M; Molden, Espen; Djurovic, Srdjan; Andreassen, Ole (Journal article; Peer reviewed, 2023)
      Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were ...

    • Polygenic risk modeling for prediction of epithelial ovarian cancer risk 

      Dareng, Eileen O.; Tyrer, Jonathan P.; Barnes, Daniel R.; Jones, Michelle R.; Yang, Xin; Aben, Katja K. H.; Adank, Muriel A.; Agata, Simona; Andrulis, Irene L.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Aravantinos, Gerasimos; Arun, Banu K.; Augustinsson, Annelie; Balmaña, Judith; Bandera, Elisa V.; Barkardottir, Rosa B.; Barrowdale, Daniel; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Benitez, Javier; Bermisheva, Marina; Bernardini, Marcus Q.; Bjørge, Line; Black, Amanda; Bogdanova, Natalia V.; Bonanni, Bernardo; Borg, Ake; Brenton, James D.; Budzilowska, Agnieszka; Butzow, Ralf; Buys, Saundra S.; Cai, Hui; Caligo, Maria A.; Campbell, Ian; Cannioto, Rikki; Cassingham, Hayley; Chang-Claude, Jenny; Chanock, Stephen J.; Chen, Kexin; Chiew, Yoke-Eng; Chung, Wendy K.; Claes, Kathleen B. M.; Colonna, Sarah; Cook, Linda S.; Couch, Fergus J.; Daly, Mary B.; Dao, Fanny; Davies, Eleanor; de la Hoya, Miguel; de Putter, Robin; Dennis, Joe; DePersia, Allison; Devilee, Peter; Diez, Orland; Ding, Yuan Chun; Doherty, Jennifer A.; Domchek, Susan M.; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana M.; Eliassen, Heather A.; Engel, Christoph; Evans, Gareth D.; Fasching, Peter A.; Flanagan, James M.; Fortner, Renée T.; Machackova, Eva; Friedman, Eitan; Ganz, Patricia A.; Garber, Judy; Gensini, Francesca; Giles, Graham G.; Glendon, Gord; Godwin, Andrew K.; Goodman, Marc T.; Greene, Mark H.; Gronwald, Jacek; Hahnen, Eric; Haiman, Christopher A.; Håkansson, Niclas; Hamann, Ute; Hansen, Thomas V. O.; Harris, Holly R.; Hartman, Mikael; Heitz, Florian; Hildebrandt, Michelle A. T.; Høgdall, Estrid; Høgdall, Claus K.; Hopper, John L.; Huang, Ruea-Yea; Huff, Chad; Hulick, Peter J.; Huntsman, David G.; Imyanitov, Evgeny N.; van der Hout, Annemieke H.; Isaacs, Claudine; Jakubowska, Anna; James, Paul A.; Janavicius, Ramunas; Jensen, Allan; Johannsson, Oskar Th.; John, Esther M.; Kang, Daehee; Karlan, Beth Y.; Karnezis, Anthony; Kelemen, Linda E.; Khusnutdinova, Elza; Kiemeney, Lambertus A.; Kim, Byoung-Gie; Kjaer, Susanne K.; Komenaka, Ian; Kupryjanczyk, Jolanta; Kurian, Allison W.; Kwong, Ava; Lambrechts, Diether; Larson, Melissa C.; Lazaro, Conxi; Le, Nhu D.; Leslie, Goska; Lester, Jenny; Lesueur, Fabienne; Levine, Douglas A.; Li, Lian; Li, Jingmei; Loud, Jennifer T.; Lu, Karen H.; Lubinski, Jan; Mai, Phuong L.; Manoukian, Siranoush; Marks, Jeffrey R.; Matsuno, Rayna Kim; Matsuo, Keitaro; May, Taymaa; McGuffog, Lesley; McLaughlin, John R.; McNeish, Iain A.; Mebirouk, Noura; Menon, Usha; Miller, Austin; Milne, Roger L.; Minlikeeva, Albina; Modugno, Francesmary; Montagna, Marco; Moysich, Kirsten B.; Munro, Elizabeth; Nathanson, Katherine L.; Neuhausen, Susan L.; Nevanlinna, Heli; Yie, Joanne Ngeow Yuen; Nielsen, Henriette Roed; Nielsen, Finn C.; Nikitina-Zake, Liene; Odunsi, Kunle; Offit, Kenneth; Olah, Edith; Olbrecht, Siel; Olopade, Olufunmilayo I.; Olson, Sara H.; Olsson, Håkan; Osorio, Ana; Papi, Laura; Park, Sue K.; Parsons, Michael T.; Pathak, Harsha; Pedersen, Inge Sokilde; Peixoto, Ana; Pejovic, Tanja; Perez-Segura, Pedro; Permuth, Jennifer B.; Peshkin, Beth; Peterlongo, Paolo; Piskorz, Anna; Prokofyeva, Darya; Radice, Paolo; Rantala, Johanna; Riggan, Marjorie J.; Risch, Harvey A.; Rodriguez-Antona, Cristina; Ross, Eric; Rossing, Mary Anne; Runnebaum, Ingo; Sandler, Dale P.; Santamariña, Marta; Soucy, Penny; Schmutzler, Rita K.; Setiawan, V. Wendy; Shan, Kang; Sieh, Weiva; Simard, Jacques; Singer, Christian F.; Sokolenko, Anna P.; Song, Honglin; Southey, Melissa C.; Steed, Helen; Stoppa-Lyonnet, Dominique; Sutphen, Rebecca; Swerdlow, Anthony J.; Tan, Yen Yen; Teixeira, Manuel; Teo, Soo Hwang; Terry, Kathryn L.; Terry, Mary Beth; Thomsen, Liv Cecilie Vestrheim; Thull, Darcy L.; Tischkowitz, Marc; Titus, Linda; Toland, Amanda E.; Torres, Diana; Trabert, Britton; Travis, Ruth; Tung, Nadine; Tworoger, Shelley S.; Valen, Ellen; van Altena, Anne M.; van der Hout, Annemieke H.; Van Nieuwenhuysen, Els; van Rensburg, Elizabeth J.; Vega, Ana; Edwards, Digna Velez; Vierkant, Robert A.; Wang, Frances; Wappenschmidt, Barbara; Webb, Penelope M.; Weinberg, Clarice R.; Weitzel, Jeffrey N.; Wentzensen, Nicolas; White, Emily; Whittemore, Alice S.; Winham, Stacey J.; Wolk, Alicja; Woo, Yin-Ling; Wu, Anna H.; Yan, Li; Yannoukakos, Drakoulis; Zavaglia, Katia M.; Zheng, Wei; Ziogas, Argyrios; Zorn, Kristin K.; Kleibl, Zdenek; Easton, Douglas; Lawrenson, Kate; DeFazio, Anna; Sellers, Thomas A.; Ramus, Susan J.; Pearce, Celeste L.; Monteiro, Alvaro N.; Cunningham, Julie; Goode, Ellen L.; Schildkraut, Joellen M.; Berchuck, Andrew; Chenevix-Trench, Georgia; Gayther, Simon A.; Antoniou, Antonis C.; Pharoah, Paul D. P. (Journal article; Peer reviewed, 2022)
      Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance ...