Blar i Department of Clinical Science på tittel
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Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes
(Journal article; Peer reviewed, 2023)Autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disease characterized by severe and childhood onset organ-specific autoimmunity caused by mutations in the autoimmune regulator (AIRE) gene. More ... -
Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort
(Journal article; Peer reviewed, 2022)Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ... -
Double paternal uniparental isodisomy 7 and 15 presenting with Beckwith–Wiedemann spectrum features
(Journal article; Peer reviewed, 2021)Here we describe for the first time double paternal uniparental isodisomy (iUPD) 7 and 15 in a baby boy with features in the Beckwith–Wiedemann syndrome spectrum (BWSp) (placentomegaly, hyperinsulinism, enlarged viscera, ... -
Double-vs single-balloon catheter for induction of labor: Systematic review and individual participant data meta-analysis
(Journal article; Peer reviewed, 2023)Introduction Evidence comparing double-balloon vs single-balloon catheter for induction of labor is divided. We aim to compare the efficacy and safety of double-vs single-balloon catheters using individual participant ... -
Drug adherence in patient group with Parkinson's disease
(Master thesis, 2018-06-29)Background Patients with Parkinson’s disease needs medicines administered frequently to manage their condition and maintain their quality of life. Poor medicine adherence may influence health negatively, and cause an ... -
Drug delivery in pancreatic cancer : Quantitative studies of gemcitabine and sonoporation in patients and cell line models
(Doctoral thesis, 2020-03-06)Background Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to late stage diagnosis and unresponsiveness to chemotherapies. A dense desmoplastic tumour stroma is considered to represent a barrier against ... -
Drug information in pregnancy. Attitudes and needs among pregnant women and physicians
(Doctoral thesis, 2013-10-25)Background: Drug use in pregnancy is common and both pregnant women and their physicians are in need of appropriate information for decision-making regarding drug therapy. However, uncertainty about the risks of drug use ... -
Durable immune responses after BNT162b2 vaccination in home-dwelling old adults
(Journal article; Peer reviewed, 2023)Objectives Elderly are an understudied, high-risk group vulnerable to severe COVID-19. We comprehensively analyzed the durability of humoral and cellular immune responses after BNT162b2 vaccination and SARS-CoV-2 infection ... -
Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation
(Journal article; Peer reviewed, 2020)Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ... -
Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls
(Peer reviewed; Journal article, 2019)Introduction: Disturbances in onset and resolution of inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. Dietary polyunsaturated fatty acids (PUFAs) can be converted into lipid mediators ... -
Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection
(Journal article; Peer reviewed, 2023)Enterotoxigenic Escherichia coli (ETEC) is an important cause of children's and travelers’ diarrhea, with no licensed vaccine. This study aimed to explore the role of cellular immunity in protection against human ETEC ... -
The dynamics of nutritional-related blood biomarker and metabolite concentrations during the postprandial and fasting states : And the implications when using nutritional-related biomarkers and metabolites in clinical care and research settings
(Doctoral thesis, 2024-04-05)BAKGRUNN: Vi vet lite om hvordan ernæringsrelaterte biomarkører og metabolitter endrer seg i blodet i postprandiell og fastende tilstand. MÅL: Å undersøke hvordan konsentrasjonen av aminosyrer, en-karbon metabolitter, ... -
Dysfunction of the protein quality control system in neurodegeneration: A study of the co-chaperone and ubiquitin ligase CHIP in vitro and in zebrafish
(Doctoral thesis, 2021-09-15)The C-terminus of Hsc70 interacting protein (CHIP) is a dimeric co-chaperone and E3 ubiquitin ligase encoded by the STIP1 homology and U-box containing protein 1 (STUB1) gene. As a major player in the protein quality control ... -
Dyspnea, lung function and CT findings three months after hospital admission for COVID-19
(Journal article; Peer reviewed, 2021)The long-term pulmonary outcomes of coronavirus disease 2019 (COVID-19) are unknown. We aimed to describe self-reported dyspnoea, quality of life, pulmonary function and chest computed tomography (CT) findings 3 months ... -
Dødsfall i sykehjem etter covid-19-vaksine
(Journal article; Peer reviewed, 2021)Bakgrunn: I perioden 27.12.2020–15.2.2021 ble om lag 29 400 av Norges ca. 35 000 sykehjemspasienter vaksinert med mRNA-vaksinen BNT162b2. I samme tidsrom mottok Statens legemiddelverk 100 meldinger om mistenkte fatale ... -
E-Learning. A study of students’ attitudes and learning outcome when using blended learning with integration of multimedia instructions
(Doctoral thesis, 2012-09-06)The advent of new technologies has provided opportunities and challenges for education institutions to seek more effective ways of teaching and learning. Elearning is now an established phenomenon in education and institutions ... -
The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α
(Peer reviewed; Journal article, 2018-08-24)The transcription factor hepatocyte nuclear factor-1α (HNF-1A) is involved in normal pancreas development and function. Rare variants in the HNF1A gene can cause monogenic diabetes, while common variants confer type 2 ... -
Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: A population-based cohort
(Journal article; Peer reviewed, 2022)Objective: The objective of this study was to evaluate the association between empirical antibiotic therapy in the first postnatal week in uninfected infants born very preterm and the risk of adverse outcomes until ... -
Early Gut Fungal and Bacterial Microbiota and Childhood Growth
(Journal article; Peer reviewed, 2020)Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ... -
Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children
(Journal article; Peer reviewed, 2020)Background Live-attenuated influenza vaccine (LAIV) was licensed for prophylaxis of children 2–17 years old in Europe in 2012 and is administered as a nasal spray. Live-attenuated influenza vaccine induces both mucosal ...