Blar i Department of Clinical Science på tittel
Viser treff 1005-1024 av 2325
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Hospitalization for acute myocardial infarction – trends in case fatality, and the impact of changing definition on number of events, subtypes and mortality
(Doctoral thesis, 2014-09-24)Background: Few studies of acute myocardial infarction (AMI) among hospitalized patients have had direct estimates of long-term case fatality after AMI, and the literature is conflicting regarding gender-related prognosis ... -
Host blood RNA transcript and protein signatures for sputum-independent diagnostics of tuberculosis in adults
(Journal article; Peer reviewed, 2021)To achieve the ambitious targets for tuberculosis (TB) prevention, care, and control stated by the End TB Strategy, new health care strategies, diagnostic tools are warranted. Host-derived biosignatures are explored for ... -
Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India
(Journal article; Peer reviewed, 2023-01-11)A large proportion of the global tuberculosis (TB) burden is asymptomatic and not detectable by symptom-based screening, driving the TB epidemic through continued M. tuberculosis transmission. Currently, no validated tools ... -
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
(Journal article; Peer reviewed, 2022)Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ... -
The Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains
(Peer reviewed; Journal article, 2011-12-20)Background: Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication. CypA interacts with the ... -
HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
(Peer reviewed; Journal article, 2015-10-24)Background: Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ... -
How does the WHO Surgical Safety Checklist fit with existing perioperative risk management strategies? An ethnographic study across surgical specialties
(Journal article; Peer reviewed, 2020)Background The World Health Organization (WHO) Surgical Safety Checklist (SSC) has demonstrated beneficial impacts on a range of patient- and team outcomes, though variation in SSC implementation and staffʼs perception ... -
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)
(Journal article; Peer reviewed, 2020)Background Many studies detect associations between parent behaviour and child symptoms of anxiety and depression. Despite knowledge that anxiety and depression are influenced by a complex interplay of genetic and ... -
How many days of continuous physical activity monitoring reliably represent time in different intensities in cancer survivors
(Journal article; Peer reviewed, 2023)Background Physical activity (PA) monitoring is applied in a growing number of studies within cancer research. However, no consensus exists on how many days PA should be monitored to obtain reliable estimates in the cancer ... -
How participatory is parental consent in low literacy rural settings in low income countries? Lessons learned from a community based study of infants in South India
(Peer reviewed; Journal article, 2011-02-15)Background A requisite for ethical human subjects research is that participation should be informed and voluntary. Participation during the informed consent process by way of asking questions is an indicator of the extent ... -
How, not if, is the question mycologists should be asking about DNA-based typification
(Journal article; Peer reviewed, 2023)Fungal metabarcoding of substrates such as soil, wood, and water is uncovering an unprecedented number of fungal species that do not seem to produce tangible morphological structures and that defy our best attempts at ... -
HSF1 Can Prevent Inflammation following Heat Shock by Inhibiting the Excessive Activation of the ATF3 and JUN&FOS Genes
(Journal article; Peer reviewed, 2022)Heat Shock Factor 1 (HSF1), a transcription factor frequently overexpressed in cancer, is activated by proteotoxic agents and participates in the regulation of cellular stress response. To investigate how HSF1 level affects ... -
Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
(Peer reviewed; Journal article, 2014)Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide ... -
Human Embryonic Development : Effects of Physical Activity and Sleep in Physiological Pregnancies
(Doctoral thesis, 2024-05-03)Bakgrunn: Forskningsfeltet "Developmental Origin of Health and Disease" (DOHaD) har vist hvor betydningsfull fosterutviklingen er for individets fremtidige helse og sykdomsrisiko. I senere år har den tidligste perioden av ... -
Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins
(Journal article; Peer reviewed, 2023)Loss-of-function mutations in hepatocyte nuclear factor 1A (HNF1A) are known to cause rare forms of diabetes and alter hepatic physiology through unclear mechanisms. In the general population, 1:100 individuals carry a ... -
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
(Journal article; Peer reviewed, 2021)While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent ... -
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
(Journal article; Peer reviewed, 2020)The etiology and pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) are unknown, and autoimmunity is one of many proposed underlying mechanisms. Human Leukocyte Antigen (HLA) associations are ... -
Human mucosal IgA immune responses against enterotoxigenic escherichia coli
(Journal article; Peer reviewed, 2020-08-29)Infection with enterotoxigenic Escherichia coli (ETEC) is a major contributor to diarrheal illness in children in low- and middle-income countries and travelers to these areas. There is an ongoing effort to develop vaccines ... -
Humanized Ovarian Cancer Patient-Derived Xenografts for Improved Preclinical Evaluation of Immunotherapies
(Journal article; Peer reviewed, 2022)High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, ... -
Humoral and cellular immune responses after pandemic and seasonal influenza vaccination in humans
(Doctoral thesis, 2022-06-22)Vaccination is the most effective prophylaxis against epidemic and pandemic influenza. Annual seasonal influenza vaccination is recommended for high-risk groups such as younger children <5 years old and occupational workers ...