Blar i Department of Clinical Science på tittel
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Impact of rapid molecular testing on diagnosis, treatment and management of community-acquired pneumonia in Norway: a pragmatic randomised controlled trial (CAPNOR)
(Journal article; Peer reviewed, 2022)Background: Community-acquired pneumonia (CAP) causes a large burden of disease. Due to difficulties in obtaining representative respiratory samples and insensitive standard microbiological methods, the microbiological ... -
Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer
(Journal article; Peer reviewed, 2021)A germline 29.5-kb deletion variant removes the 3’ end of the APOBEC3A gene and a large part of APOBEC3B, creating a hybrid gene that has been linked to increased APOBEC3 activity and DNA damage in human cancers. We genotyped ... -
Impact of the left ventricular lead on the efficacy of Cardiac Resynchronization Therapy for heart failure. : Electrophysiologic and clinical trials investigating active fixation left ventricular lead in cardiac resynchronization therapy.
(Doctoral thesis, 2021-04-09)Background: This thesis examines the performance of different left ventricular (LV) leads and in particular a novel bipolar LV lead with a side helix for active fixation. Cardiac resynchronization therapy (CRT) provides ... -
Impact of the metabolic syndrome on cardiopulmonary morbidity and mortality in individuals with lung function impairment: a prospective cohort study of the Danish general population
(Journal article; Peer reviewed, 2023)Background Whether the metabolic syndrome plays a role for the prognosis of individuals with lung function impairment (preserved ratio impaired spirometry (PRISm) or airflow limitation) is unclear. We hypothesised that ... -
Impact of the WHO Surgical Safety Checklist implementation on perioperative work and risk perceptions : A process evaluation by use of quantitative and qualitative methods
(Doctoral thesis, 2020-02-14)Background: Human performance deficiencies account for a large proportion of adverse surgical events. The World Health Organization (WHO) Surgical Safety Checklist (SSC) was launched to improve teamwork and patient outcome. ... -
Impact of the World Health Organization’s Surgical Safety Checklist on safety culture in the operating theatre: a controlled intervention study
(Peer reviewed; Journal article, 2013-05)Background: Positive changes in safety culture have been hypothesized to be one of the mechanisms behind the reduction in mortality and morbidity after the introduction of the World Health Organization’s Surgical Safety ... -
Impact on follow-up strategies in patients with primary sclerosing cholangitis
(Journal article; Peer reviewed, 2022)Background & Aims: Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow-up strategies in ... -
The impacts of contact force, power and application time on ablation effect indicated by serial measurements of impedance drop in both conventional and high-power short-duration ablation settings of atrial fibrillation
(Journal article; Peer reviewed, 2021)Background: This study aimed to clarify the interrelationship and additive effects of contact force (CF), power and application time in both conventional and high-power short-duration (HPSD) settings. Methods: Among 38 ... -
Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome
(Journal article; Peer reviewed, 2022)Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases. ... -
Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism
(Journal article; Peer reviewed, 2023)Context The neutral amino acid transporter SLC7A10/ASC-1 is an adipocyte-expressed gene with reduced expression in insulin resistance and obesity. Inhibition of SLC7A10 in adipocytes was shown to increase lipid accumulation ... -
Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father, and Child Cohort Study
(Journal article; Peer reviewed, 2024)Study question: Are impaired glucose tolerance (as measured by fasting glucose, glycated hemoglobin, and fasting insulin) and cardiovascular disease risk (as measured by low-density lipoprotein cholesterol, high-density ... -
Impaired gross motor development in infants with higher PFAS concentrations
(Journal article; Peer reviewed, 2022)Industrial produced perfluoroalkyl substances (PFAS) are environmentally persistent and found in humans around the globe. PFAS is transferred from mother to child during pregnancy and lactation and PFAS concentrations are ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Peer reviewed; Journal article, 2019-07-01)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ... -
Impaired high-density lipoprotein function in patients with heart failure
(Journal article; Peer reviewed, 2021)Background We recently showed that, in patients with heart failure, lower high‐density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow‐up study, ... -
Impaired Lung Function in Extremely Preterm-Born Adults in Their Fourth Decade of Life
(Journal article; Peer reviewed, 2023) -
Impaired lymphatic function accelerates cancer growth
(Peer reviewed; Journal article, 2016-06-13)Increased lymphangiogenesis is a common feature of cancer development and progression, yet the influence of impaired lymphangiogenesis on tumor growth is elusive. C3HBA breast cancer and KHT-1 sarcoma cell lines were ... -
imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics
(Journal article; Peer reviewed, 2021)Liquid biopsies offer a minimally invasive sample collection, outperforming traditional biopsies employed for cancer evaluation. The widely used material is blood, which is the source of tumor-educated platelets. Here, we ... -
Implementation of a dual platelet inventory in a tertiary hospital during the COVID-19 pandemic enabling cold-stored apheresis platelets for treatment of actively bleeding patients
(Journal article; Peer reviewed, 2022)Background: To increase preparedness and mitigate the risk of platelet shortage without increasing the number of collections, we introduced a dual platelet inventory with cold-stored platelets (CSP) with 14-days shelf life ... -
The implementation of mass spectrometry-based proteomics workflows in clinical routines of acute myeloid leukemia: Applicability and perspectives
(Journal article; Peer reviewed, 2020)With the current reproducibility of proteome preparation workflows along with the speed and sensitivity of the mass spectrometers, the transition of the mass spectrometry (MS)-based proteomics technology from biomarker ... -
Implementation of Medical Abortion in Norway 1998-2013
(Doctoral thesis, 2015-04-17)Background. Medical abortion is a secure way of terminating a pregnancy. Since 1998, medical abortion with mifepristone and misoprostol has been available in Norway. During the last 16 years, the accessibility and use have ...