Browsing Department of Clinical Science by Title
Now showing items 1451-1470 of 2340
-
Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis
(Journal article; Peer reviewed, 2020-01-10)Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from ... -
Molecular characterization of antibiotic resistant bacteria in newly HIV diagnosed adults in a community setting in Tanzania. Implications for infection prevention and control in HIV : Antibiotic resistant bacteria, HIV, Community, Sub-Saharan Africa
(Doctoral thesis, 2022-08-26)Mennesker som lever med HIV-infeksjon i utviklingsland har økt risiko for å bli smittet med antibiotikaresistente bakterier. Høyere forbruk av antibiotika på grunn av HIV-relatert sykdom gir et seleksjonspress som kan føre ... -
Molecular characterization of Corynebacterium diphtheriae isolates, Russia, 1957-1987
(Peer reviewed; Journal article, 2002)In the 1990s, the Newly Independent and Baltic States of the former Soviet Union experienced the largest diphtheria outbreak since the 1960s; it was caused by Corynebacterium diphtheriae strains of a unique clonal group. ... -
Molecular markers to predict prognosis and guide therapy in endometrial cancer
(Doctoral thesis, 2020-02-07)Background: Endometrial cancer is the most common gynecological malignancy in the Western world. The disease occurs in the epithelial lining of the uterus, called the endometrium. Although prognosis is good and most of the ... -
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
(Peer reviewed; Journal article, 2014-05-21)Background: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have ... -
Molecular mechanisms of sonoporation in cancer therapy : Optimization of sonoporation parameters and investigations of intracellular signalling
(Doctoral thesis, 2020-06-17)Background: Sonoporation, which is treatment with ultrasound (US) and microbubbles (MB), has shown great potential for enhancing the therapeutic efficacy of chemotherapy in cancer therapy. However, there is still very ... -
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
(Journal article, 2021)Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an underlying molecular diversity. Here, we aimed at ... -
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
(Peer reviewed; Journal article, 2014-09-27)Background: About 20% of patients diagnosed with endometrial cancer (EC) are considered high-risk with unfavorable prognosis. In the framework of the European Network for Individualized Treatment in EC (ENITEC), we ... -
Monitoring children and adolescents with severe obesity: body mass index (BMI), BMI z‐score or percentage above the International Obesity Task Force overweight cut‐off?
(Peer reviewed; Journal article, 2019)Aim: Body mass index (BMI) metrics are widely used as a proxy for adiposity in children with severe obesity. The BMI expressed as the percentage of a cut‐off percentile for overweight or obesity has been proposed as a ... -
Monitoring multiple myeloma by quantification of recurrent mutations in serum
(Peer reviewed; Journal article, 2017)Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ... -
The monocyte system in haematological malignancies
(Doctoral thesis, 2020-04-17)Monocytes consist of classical, intermediate, and non-classical monocytes. In haematological malignancies, such as multiple myeloma and acute myeloid leukaemia, monocytes are affected by both the disease itself and the ... -
Monocyte-derived dendritic cells in cancer immunotherapy : Considerations on their applicability
(Doctoral thesis, 2021-02-17)Cancer is the leading cause of death in the developed world. While treatment options and detection have improved over the last century, mortality rate remains high especially in metastatic disease. Traditional treatment ... -
Morphine enhances doxorubicin-induced cardiotoxicity in the rat
(Peer reviewed; Journal article, 2014-09)Interventions to reduce the cardiotoxicity of doxorubicin are clinically relevant. Pharmacological preconditioning mimicking ischemic preconditioning has been demonstrated with morphine and represents an acceptable clinical ... -
Mortality related to hospital-associated infections in a tertiary hospital; repeated cross-sectional studies between 2004-2011
(Peer reviewed; Journal article, 2015-12-29)Background: Hospital-associated infections (HAIs) are reported to increase patient mortality and incur longer hospital stays. Most studies to date have focused on specific groups of hospitalised patients with a rather short ... -
Motivation and response rates in bronchoscopy studies
(Peer reviewed; Journal article, 2019-05-02)Background Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation ... -
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial
(Peer reviewed; Journal article, 2015-12-18)Background: Exclusive breastfeeding for 6 months is assumed to ensure adequate micronutrients for term infants. Our objective was to investigate the effects of prolonged breastfeeding on B vitamin status and neurodevelopment ... -
Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial
(Journal article; Peer reviewed, 2021)Background Moxetumomab pasudotox is a recombinant CD22-targeting immunotoxin. Here, we present the long-term follow-up analysis of the pivotal, multicenter, open-label trial (NCT01829711) of moxetumomab pasudotox in ... -
MRI adipose tissue segmentation and quantification in R (RAdipoSeg)
(Journal article; Peer reviewed, 2022-10-08)Background: Excess adipose tissue is associated with increased cardiovascular and metabolic risk, but the volume of visceral and subcutaneous adipose tissue poses different metabolic risks. MRI with fat suppression can be ... -
MtDNA sequence features associated with 'selfish genomes' predict tissue-specific segregation and reversion
(Journal article; Peer reviewed, 2020)Mitochondrial DNA (mtDNA) encodes cellular machinery vital for cell and organism survival. Mutations, genetic manipulation, and gene therapies may produce cells where different types of mtDNA coexist in admixed populations. ... -
MTHFD1 and relevant biomarkers in cardiovascular disease: Observational studies in patients with suspected stable angina pectoris in Norway
(Doctoral thesis, 2017-03-24)Background: As the leading cause of death globally, cardiovascular disease (CVD) is a major public health burden. Epidemiological and experimental studies consistently demonstrate an association between elevated total ...