Blar i Department of Clinical Science på tittel

Viser treff 1530-1549 av 2325

    • A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer 

      Fletcher, C.E.; Deng, L.; Orafidiya, F.; Yuan, W.; Lorentzen, M.P.G.S.; Cyran, O.W.; Varela-Carver, A.; Constantin, T.A.; Leach, D.A.; Dobbs, F.M.; Figueiredo, I.; Gurel, B.; Parkes, E.; Bogdan, D.; Pereira, R.R.; Zhao, S.G.; Neeb, A.; Issa, F.; Hester, J.; Kudo, H.; Liu, Y.; Philippou, Y.; Bristow, R.; Knudsen, K.; Bryant, R.J.; Feng, F.Y.; Reed, S.H.; Mills, Ian; de Bono, Bono; Bevan, C.L. (Journal article; Peer reviewed, 2022-03-22)
      Background: miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 ...

    • NordAqua, a Nordic Center of Excellence to develop an algae-based photosynthetic production platform 

      Allahverdiyeva, Yagut; Aro, Eva-Mari; Bavel, Bert van; Escudero, Carlos; Funk, Christiane; Heinonen, Jarna; Herfindal, Lars; Lindblad, Peter; Makinen, Sari; Penttilä, Merja; Sivonen, Kaarina; Chauton, Matilde Skogen; Skomedal, Hanne; Skjermo, Jorunn (Journal article; Peer reviewed, 2021)
      NordAqua is a multidisciplinary Nordic Center of Excellence funded by NordForsk Bioeconomy program (2017–2022). The research center promotes Blue Bioeconomy and endeavours to reform the use of natural resources in a ...

    • The Norwegian blood preparedness project: A whole blood program including civilian walking blood banks for early treatment of patients with life-threatening bleeding in municipal health care services, ambulance services, and rural hospitals 

      Apelseth, Torunn Oveland; Grujic Arsenovic, Mirjana; Strandenes, Geir (Journal article; Peer reviewed, 2022)
      Background Civilian and military guidelines recommend early balanced transfusion to patients with life-threatening bleeding to improve survival. To provide the best care to patients with hemorrhagic shock in regions with ...

    • Norwegian children and adolescents in blended families are at risk of larger one-year BMI increments 

      Kristiansen, Hege; Roelants, Mathieu; Bjerknes, Robert; Juliusson, Petur Benedikt (Peer reviewed; Journal article, 2020)
      Aim: To study how sociodemographic factors and family structure associate with baseline BMI z‐scores (BMIz) and BMIz change in 767 Norwegian children aged 6‐15 years. Methods: Baseline BMIz and 1‐year BMIz increments in ...

    • Novel adipose genes in substrate- and depot-dependent lipid accumulation 

      Tallapragada, Divya Sri Priyanka (Doctoral thesis, 2021-06-24)
      Altered adipose tissue function in obesity is linked to increased risk of type 2 diabetes (T2D) and cardiometabolic diseases via insulin resistance, visceral adiposity, hypertension, and other traits. This thesis studied ...

    • A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium 

      Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun; Diaz, Andrea Estefania Carpinteyro; Herfindal, Lars; Fossen, Torgils (Journal article; Peer reviewed, 2022)
      Garden chervil, Anthriscus cerefolium (L.) Hoffm. is an important herb commonly applied in Norwegian large-scale commercial kitchens. This species is a highly enriched source of phenolics, containing 1260 mg gallic acid ...

    • A novel case of impaired C-reactive protein response following open-heart surgery: A case report and review of the literature 

      Vinnes, Erik Wilhelm; Lillemoen, Paul Kjetil Soldal; Persson, Robert; Meyer, Klaus; Haaverstad, Rune; Monsen, Anne-Lise Bjørke (Journal article; Peer reviewed, 2021)
      Background C-reactive protein (CRP) is expected to increase in response to a range of inflammatory stimuli such as infections or extensive tissue trauma. Case report We present a novel case of severely impaired CRP ...

    • A novel concentrated, interdisciplinary group rehabilitation program for patients with chronic obstructive pulmonary disease: Protocol for a nonrandomized clinical intervention study 

      Frisk, Bente; Njøten, Kiri Lovise; Aarli, Bernt Bøgvald; Hystad, Sigurd William; Rykken, Sidsel; Kjosås, Ane; Søfteland, Eirik; Kvale, Gerd (Journal article; Peer reviewed, 2022)
      Background: Pulmonary rehabilitation has been demonstrated to be a highly effective treatment for people with chronic obstructive pulmonary disease (COPD). However, its availability is scarce worldwide, and new and ...

    • A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function 

      Lam, M.; Coppola, S.; Krumbach, Oliver H.F.; Prencipe, Giuseppe; Insalaco, Antonella; Cifaldi, C.; Brigida, I.; Zara, Erika; Scala, Serena; Di Cesare, Silvia; Martinelli, Simone; Di Rocco, Martina; Pascarella, Antonia; Niceta, Marcello; Pantaleoni, Francesca; Ciolfi, Andrea; Netter, Petra; Carisey, Alexandre; Diehl, Michael; Akbarzadeh, Mohammad; Conti, Francesca; Merli, Pietro; Pastore, Anna; Mortera, Stefano Levi; Camerini, Serena; Farina, L; Buchholzer, Marcel; Pannone, L.; Cao, T.; Coban-Akdemir, Zeynep H.; Jhangiani, Shalini N.; Muzny, Donna M.; Gibbs, Richard A.; Basso-Ricci, L.; Chiriaco, M.; Dvorsky, Radovan; Putignani, L.; Carsetti, Rita; Janning, Petra; Stray-Pedersen, Asbjørg; Erichsen, Hans Christian; Horne, AnnaCarin; Bryceson, Yenan; Torralba-Raga, Lamberto; Ramme, Kim; Rosti, Vittorio; Bracaglia, Claudia; Messia, Virginia; Palma, Paolo; Finocchi, Andrea; Lupski, James R. (Peer reviewed; Journal article, 2019)
      Hemophagocytic lymphohistiocytosis (HLH) is characterized by immune dysregulation due to inadequate restraint of overactivated immune cells and is associated with a variable clinical spectrum having overlap with more common ...

    • Novel endoscopic and MRI-based methods for evaluating exocrine pancreatic function in pancreatitis and monogenic forms of diabetes 

      Tjora, Erling (Doctoral thesis, 2013-11-15)
      Background: Monogenic diabetes (Maturity onset diabetes in the young, MODY) are autosomal dominantly inherited diabetes syndromes characterized by diabetes due to beta cell dysfunction, with typical onset of diabetes before ...

    • A novel fibrosis index comprising a non-cholesterol sterol accurately predicts HCV-related liver cirrhosis 

      Ydreborg, Magdalena; Lisovskaja, Vera; Lagging, Martin; Christensen, Peer Brehm; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Wejstål, Rune; Norkrans, Gunnar; Lindh, Magnus; Färkkilä, Martti; Westin, Johan (Peer reviewed; Journal article, 2014-04-03)
      Diagnosis of liver cirrhosis is essential in the management of chronic hepatitis C virus (HCV) infection. Liver biopsy is invasive and thus entails a risk of complications as well as a potential risk of sampling error. ...

    • A novel Geriatric Assessment frailty score predicts two-year mortality after Transcatheter Aortic Valve implantation 

      Skaar, Elisabeth; Eide, Leslie Sofia Pareja; Norekvål, Tone M.; Ranhoff, Anette Hylen; Nordrehaug, Jan Erik; Forman, Daniel E.; Schönenberger, Anders; Hufthammer, Karl Ove; Kuiper, Karel Kier-Jan; Bleie, Øyvind; Haaverstad, Rune; Schaufel, Margrethe Aase; Packer, Erik Jerome Stene; Langørgen, Jørund (Peer reviewed; Journal article, 2018-10-31)
      Aims Established surgical scores have limitations in delineating risk among candidates for transcatheter aortic valve implantation (TAVI). Assessment of frailty might help to estimate the mortality risk and identify patients ...

    • Novel inflammatory biomarkers in thyroid eye disease 

      Ueland, Hans Olav; Ueland, Grethe Åstrøm; Løvås, Kristian; Breivik, Lars Ertesvåg; Thrane, Alexander Stanley; Stokland, Ann-Elin Meling; Rødahl, Eyvind; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2022)
      Purpose: The aim of this study is to identify biochemical inflammatory markers predicting the presence or risk of developing thyroid eye disease (TED) in patients with Graves' disease (GD). Methods: Patients with GD ...

    • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits 

      Vogelezang, Suzanne; Bradfield, Jonathan P.; Ahluwalia, Tarunveer S.; Curtin, John A.; Lakka, Timo A.; Grarup, Niels; Scholz, Markus; van der Most, Peter J.; Monnereau, Claire; Stergiakouli, Evie; Heiskala, Anni; Horikoshi, Momoko; Fedko, Iryna O.; Vilor-Tejedor, Natalia; Cousminer, Diana L.; Standl, Marie; Wang, Carol A.; Viikari, Jorma; Geller, Frank; Íñiguez, Carmen; Pitkänen, Niina; Chesi, Alessandra; Bacelis, Jonas; Yengo, Loic; Torrent, Maties; Ntalla, Ioanna; Helgeland, Øyvind; Selzam, Saskia; Vonk, Judith M.; Zafarmand, Mohammed H.; Heude, Barbara; Farooqi, Ismaa Sadaf; Alyass, Akram; Beaumont, Robin N.; Have, Christian T.; Rzehak, Peter; Bilbao, Jose Ramon; Schnurr, Theresia M.; Barroso, Inês; Bønnelykke, Klaus; Beilin, Lawrence J.; Carstensen, Lisbeth; Charles, Marie-Aline; Chawes, Bo; Clément, Karine; Closa-Monasterolo, Ricardo; Custovic, Adnan; Eriksson, Johan G.; Vaudel, Marc; Njølstad, Pål Rasmus (Journal article; Peer reviewed, 2020)
      The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed ...

    • The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer 

      Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege; Lønning, Per Eystein; Knappskog, Stian (Journal article; Peer reviewed, 2020)
      miRNAs are an important class of small non-coding RNAs, which play a versatile role in gene regulation at the post-transcriptional level. Expression of miRNAs is often deregulated in human cancers. We analyzed small RNA ...

    • Novel neonatal simulator provides high-fidelity ventilation training comparable to real-life newborn ventilation 

      Haynes, Joanna; Bjorland, Peder Aleksander; Gomo, Øystein; Ushakova, Anastasia; Rettedal, Siren; Perlman, Jeffrey M.; Ersdal, Hege Langli (Journal article; Peer reviewed, 2021)
      Face mask ventilation of apnoeic neonates is an essential skill. However, many non-paediatric healthcare personnel (HCP) in high-resource childbirth facilities receive little hands-on real-life practice. Simulation training ...

    • Novel PCDH10-Wnt-MALAT1 regulatory axis in endometrioid endometrial adenocarcinoma 

      Zhao, Y.; Yang, Y.; Trovik, Jone; Sun, Kun; Zhou, Liang; Jiang, Peiyong; Lau, Tatsan; Høivik, Erling Andre; Salvesen, Helga; Sun, H.; Wang, H. (Peer reviewed; Journal article, 2019)
      Key Messages: 1. Protocadherin 10 (PCDH10) is silenced in endometrioid endometrial cancer through promoter hypermethylation. 2. Ectopic expression of PCDH10 inhibits tumour growth and induces cell apoptosis. 3. Transcriptomic ...

    • Novel preoperative biomarkers and evaluation of altered treatment strategies to improve outcome for endometrial cancer patients 

      Forsse, David (Doctoral thesis, 2021-10-01)
      Background: Endometrial cancer is the most common gynecological cancer among women in countries with a high developmental index, and the incidence is expected to rise. Major controversies in the treatment of endometrial ...

    • A Novel Prophylaxis Strategy Using Liposomal Vaccine Adjuvant CAF09b Protects against Influenza Virus Disease 

      Zimmermann, Julie; Schmidt, Signe Tandrup; Trebbien, Ramona; Cox, Rebecca Jane; Zhou, Fan; Follmann, Frank; Pedersen, Gabriel Kristian; Christensen, Dennis (Journal article; Peer reviewed, 2022-02-06)
      The SARS-CoV-2 pandemic caused a massive health and societal crisis, although the fast development of effective vaccines reduced some of the impact. To prepare for future respiratory virus pandemics, a pan-viral prophylaxis ...

    • Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding 

      Zondag, Timo C. E.; Torralba-Raga, Lamberto; Van Laar, Jan A. M.; Hermans, Maud A. W.; Bouman, Arjen; Hollink, Iris H. I. M.; Van Hagen, P. Martin; Briggs, Deborah A.; Hume, Alistair N.; Bryceson, Yenan (Journal article; Peer reviewed, 2022)
      Autosomal recessive mutations in RAB27A are associated with Griscelli syndrome type 2 (GS2), characterized by hypopigmentation and development of early-onset, potentially fatal hemophagocytic lymphohistiocytosis (HLH). We ...