Blar i Department of Clinical Science på tittel

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    • Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity 

      Bartaula-Brevik, Sushma; Leitch, Calum; Valladares, Maria del Carmen Hernandez; Aasebø, Elise; Berven, Frode Steingrimsen; Selheim, Frode; Brenner, Annette; Rye, Kristin Paulsen; Hagen, Marie; Reikvam, Håkon; Mc Cormack, Emmet; Bruserud, Øystein; Tvedt, Tor Henrik Anderson (Journal article; Peer reviewed, 2023)
      Vacuolar ATPase (V-ATPase) is regarded as a possible target in cancer treatment. It is expressed in primary acute myeloid leukemia cells (AML), but the expression varies between patients and is highest for patients with a ...

    • Validation of a Harmonized Enzyme-Linked-Lectin-Assay (ELLA-NI) Based Neuraminidase Inhibition Assay Standard Operating Procedure (SOP) for Quantification of N1 Influenza Antibodies and the Use of a Calibrator to Improve the Reproducibility of the ELLA-NI With Reverse Genetics Viral and Recombinant Neuraminidase Antigens: A FLUCOP Collaborative Study 

      Bernard, Marie-Clotilde; Waldock, Joanna; Commandeur, Sylvie; Strauß, Lea; Trombetta, Claudia Maria; Marchi, Serena; Zhou, Fan; van de Witte, Serge; van Amsterdam, Peter; Ho, Sammy; Hoschler, Katja; Lugovtsev, Vladimir; Weir, Jerry P.; Montomoli, Emanuele; Cox, Rebecca Jane; Engelhardt, Othmar G.; Friel, Damien; Wagner, Ralf; Ollinger, Thierry; Germain, Sophie; Sediri-Schön, Hanna (Journal article; Peer reviewed, 2022)
      Current vaccination strategies against influenza focus on generating an antibody response against the viral haemagglutination surface protein, however there is increasing interest in neuraminidase (NA) as a target for ...

    • Validation of a modified South African triage scale in a high-resource setting: a retrospective cohort study 

      Markussen, Dagfinn Lunde; Brevik, Heidi Synnøve; Bjørneklett, Rune Oskar; Engan, Mette (Journal article; Peer reviewed, 2023-03-20)
      Background: Triage systems are widely used in emergency departments, but are not always validated. The South African Triage Scale (SATS) has mainly been studied in resource-limited settings. The aim of this study was to ...

    • Validation of Chichewa short musculoskeletal function assessment (SMFA) questionnaire: A cross-sectional study 

      Chokotho, Linda; Lau, Brian C.; Conway, Devin; Wu, Hao-Hua; Shearer, David; Hallan, Geir; Gjertsen, Jan-Erik; Mkandawire, Nyengo; Young, Sven (Peer reviewed; Journal article, 2019-03)
      Background: The Short Musculoskeletal Function Assessment (SMFA) tool measures function and quality of life in patients with musculoskeletal conditions. Objective: This study aimed to translate and adapt culturally the ...

    • The valine-3-HIB pathway in obesity, insulin resistance and fatty liver 

      Bjune, Mona Synnøve (Doctoral thesis, 2022-06-10)
      The prevalence of obesity has increased greatly during the last decades, along with obesity-associated conditions and diseases including insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD). ...

    • The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure 

      Pandhi, Paloma; Streng, Koen W.; Anker, Stefan D.; Cleland, John G.; Damman, Kevin; Dickstein, Kenneth; Pellicori, Pierpaolo; Lang, Chim C.; Ng, Leong; Samani, Nilesh J.; Zannad, Faiez; Metra, Marco; Rossignol, Patrick; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Voors, Adriaan A.; ter Maaten, Jozine M. (Journal article; Peer reviewed, 2021)
      Background Muscle wasting and unintentional weight loss (cachexia) have been associated with worse outcomes in heart failure (HF), but timely identification of these adverse phenomena is difficult. Spot urinary creatinine ...

    • Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA–DQ Locus 

      Trutschel, Diana; Bost, Pierre; Mariette, Xavier; Bondet, Vincent; Llibre, Alba; Posseme, Celine; Charbit, Bruno; Thorball, Christian W.; Jonsson, Roland; Lessard, Christopher J.; Felten, Renaud; Ng, Wan Fai; Chatenoud, Lucienne; Dumortier, Hélène; Sibilia, Jean; Fellay, Jacques; Brokstad, Karl Albert; Appel, Silke; Tarn, Jessica R; Quintana-Murci, Lluis; Mingueneau, Michael; Meyer, Nicolas; Duffy, Darragh; Schwikowski, Benno; Gottenberg, Jacques Eric (Journal article; Peer reviewed, 2022)
      Objective Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with ...

    • Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration 

      Liu, Xueping; Helenius, Dorte; Skotte, Line; Beaumont, Robin N.; Wielscher, Matthias; Geller, Frank; Juodakis, Julius; Mahajan, Anubha; Bradfield, Jonathan P.; Lin, Frederick T.J.; Vogelezang, Suzanne; Bustamante, Mariona; Ahluwalia, Tarunveer S.; Pitkänen, Niina; Wang, Carol A.; Bacelis, Jonas; Borges, Maria C.; Zhang, Ge; Bedell, Bruce A.; Rossi, Robert M.; Skogstrand, Kristin; Peng, Shouneng; Thompson, Wesley Kurt; Appadurai, Vivek; Lawlor, Debbie A.; Kalliala, Ilkka; Power, Christine; McCarthy, Mark I.; Boyd, Heather A.; Marazita, Mary L.; Hakonarson, Hakon; Hayes, M. Geoffrey; Scholtens, Denise M.; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Vinding, Rebecca K.; Bisgaard, Hans; Knight, Bridget A.; Pahkala, Katja; Raitakari, Olli; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Fadista, João; Schork, Andrew J.; Nudel, Ron; Miller, Daniel E.; Chen, Xiaoting; Weirauch, Matthew T.; Mortensen, Preben Bo; Børglum, Anders D.; Nordentoft, Merete; Mors, Ole; Hao, Ke; Ryckman, Kelli K.; Hougaard, David M.; Kottyan, Leah C.; Pennell, Craig E.; Lyytikäinen, Leo-Pekka; Bønnelykke, Klaus; Vrijheid, Martine; Felix, Janine F.; Lowe, William L.; Grant, Struan F.A.; Hyppönen, Elina; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Muglia, Louis J.; Murray, Jeffrey C.; Freathy, Rachel M.; Werge, Thomas M.; Melbye, Mads; Buil, Alfonso; Feenstra, Bjarke (Peer reviewed; Journal article, 2019-09-02)
      The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ...

    • Variasjoner i bruk av psykofarmaka ved sykehjem i Trondheim kommune 

      Hjortland, Anja (Master thesis, 2019-06-22)
      Sykehjemspasientene er blant den skjøreste pasientpopulasjonen, mer enn 80% av sykehjemspasienter har demens, og flere av disse bruker en eller flere psykotrope legemidler daglig. Når kroppen blir eldre er det mye som ...

    • Variation in antibiotic consumption in very preterm infants-a 10 year population-based study 

      Huncikova, Zuzana; Stensvold, Hans Jørgen; Øymar, Knut Asbjørn Alexander; Vatne, Anlaug; Lang, Astri Maria; Støen, Ragnhild; Brigtsen, Anne Karin; Moster, Dag; Eriksen, Beate Horsberg; Selberg, Terje Reidar; Rønnestad, Arild Erland; Klingenberg, Claus (Journal article; Peer reviewed, 2023)
      Objectives Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among ...

    • Vascular endothelial function assessed by flow-mediated vasodilatation in young adults born very preterm or with extremely low birthweight: A regional cohort study 

      Engan, Britt; Engan, Mette; Greve, Gottfried; Vollsæter, Maria; Hufthammer, Karl Ove; Leirgul, Elisabeth (Journal article; Peer reviewed, 2021)
      Background: Preterm birth and low birthweight have been associated with increased risk of cardiovascular disease in young adults. Endothelial dysfunction is established as an early marker for development of atherosclerotic ...

    • Vascular normalisation as the stepping stone into tumour microenvironment transformation 

      Magnussen, Anette L.; Mills, Ian (Journal article; Peer reviewed, 2021)
      A functional vascular system is indispensable for drug delivery and fundamental for responsiveness of the tumour microenvironment to such medication. At the same time, the progression of a tumour is defined by the interactions ...

    • Vegan diet and bone health—results from the cross-sectional RBVD study 

      Menzel, Juliane; Abraham, Klaus; Stangl, Gabriele I.; Ueland, Per Magne; Obeid, Rima; Schulze, Matthias B.; Herter-Aeberli, Isabelle; Schwerdtle, Tanja; Weikert, Cornelia (Journal article; Peer reviewed, 2021)
      Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with ...

    • Ventilator flow data predict bronchopulmonary dysplasia in extremely premature neonates 

      Bentsen, Mariann; Markestad, Trond; Halvorsen, Thomas (Journal article; Peer reviewed, 2018)
      Early prediction of bronchopulmonary dysplasia (BPD) may facilitate tailored management for neonates at risk. We investigated whether easily accessible flow data from a mechanical ventilator can predict BPD in neonates ...

    • Ventilatory efficiency in children and adolescents born extremely preterm 

      Hestnes, Julie; Hoel, Hedda Benedicte; Risa, Ole J.; Romstøl, Hanna O.; Røksund, Ola Drange; Frisk, Bente; Thorsen, Einar; Halvorsen, Thomas; Clemm, Hege Synnøve Havstad (Peer reviewed; Journal article, 2017-07-13)
      Purpose: Children and adolescents born extremely preterm (EP) have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ...

    • Vinorelbine and gemcitabine vs vinorelbine and carboplatin as first-line treatment of advanced NSCLC. A phase III randomised controlled trial by the Norwegian Lung Cancer Study Group 

      Fløtten, Øystein; Grønberg, Bjørn Henning; Bremnes, Roy M.; Amundsen, Tore; Sundstrøm, Stein Harald; Rolke, Heidi; Hornslien, Kjersti; Wentzel-Larsen, Tore; Aasebø, Ulf; von Plessen, Christian (Journal article; Peer reviewed, 2012)
      Background: Platinum-based doublet chemotherapy is the standard first-line treatment for advanced non-small cell lung cancer (NSCLC), but earlier studies have suggested that non-platinum combinations are equally effective ...

    • Viral diarrhoea in children under two years of age in Dar es Salaam, Tanzania. Clinical and molecular epidemiology 

      Moyo, Sabrina John (Doctoral thesis, 2014-12-08)
      Introduction: Diarrhoeal disease is one of the leading causes of illness and death in children below five years, especially in developing countries. It is estimated to cause 0.7 million deaths among children younger than ...

    • Virtual reality simulation training in stroke thrombectomy centers with limited patient volume—Simulator performance and patient outcome 

      Søvik, Olav; Tveiten, Arnstein; Øygarden, Halvor; Stokkeland, Pål Johan; Hetland, Hanne Brit; Schneider, Magnus Sundgot; Sandve, Knut Olav Lende; Altmann, Marianne; Hykkerud, Dan L; Ospel, Johanna; Goyal, Mayank; Ersdal, Hege Langli; Kurz, Martin; Hyldmo, Per Kristian (Journal article; Peer reviewed, 2023)
      Background Virtual reality simulation training may improve the technical skills of interventional radiologists when establishing endovascular thrombectomy at limited-volume stroke centers. The aim of this study was to ...

    • Visceral fat percentage for prediction of outcome in uterine cervical cancer 

      Eide, Agnes J.; Halle, Mari Kyllesø; Lura, Njål; Fasmer, Kristine Eldevik; Wagner-Larsen, Kari Strøno; Forsse, David Erik; Bertelsen, Bjørn; Salvesen, Øyvind Olav; Krakstad, Camilla; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2023)
      Objective The prognostic role of adiposity in uterine cervical cancer (CC) is largely unknown. Abdominal fat distribution may better reflect obesity than body mass index. This study aims to describe computed tomography ...

    • Vitamin B12 Deficiency (Un-)Detected Using Newborn Screening in Norway 

      Tangeraas, Trine; Ljungblad, Ulf Wike; Lutvica, Elma; Kristensen, Erle; Rowe, Alexander D.; Monsen, Anne-Lise Bjørke; Rootwelt-Revheim, Terje; Sæves, Ingjerd; Pettersen, Rolf Dagfinn (Journal article; Peer reviewed, 2023)
      Untreated vitamin B12 (B12) deficiency may cause delayed development in infants. Several newborn screening (NBS) programs have reported an increased detection rate of B12 deficiency when second-tier dried blood spot (DBS) ...