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Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
(Peer reviewed; Journal article, 2019)Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ... -
Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci
(Journal article; Peer reviewed, 2022)Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness ... -
Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
(Journal article; Peer reviewed, 2021)Background Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies have reported potential comorbidity between the ... -
Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci
(Journal article; Peer reviewed, 2023)Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a ... -
Genome-wide association meta-analysis of childhood and adolescent internalizing symptoms
(Journal article; Peer reviewed, 2022)Objective: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. Method: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated ... -
Genome-wide association study identifies 30 loci associated with bipolar disorder
(Journal article; Peer reviewed, 2019)Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with ... -
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
(Peer reviewed; Journal article, 2015-12-03)Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ... -
Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
(Journal article; Peer reviewed, 2022)Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s cases of ... -
A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
(Peer reviewed; Journal article, 2009-03-20)There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor is severe deficiency of α1-antitrypsin, which is present in ... -
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
(Peer reviewed; Journal article, 2017-06-20)Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder ... -
A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts
(Journal article; Peer reviewed, 2022)Introduction Bronchodilator response (BDR) is a measurement of acute bronchodilation in response to short-acting β2-agonists, with a heritability between 10 and 40%. Identifying genetic variants associated with BDR may ... -
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
(Journal article; Peer reviewed, 2024)Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. ... -
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth
(Peer reviewed; Journal article, 2019-10-01)Infant and childhood growth are dynamic processes with large changes in BMI during development. By performing genome-wide association studies of BMI at 12 time points from birth to eight years (9286 children, 74,105 ... -
Genome-wide copy number variation (CNV) in patients with autoimmune Addison’s disease
(Peer reviewed; Journal article, 2011-08-18)Background: Addison’s disease (AD) is caused by an autoimmune destruction of the adrenal cortex. The pathogenesis is multi-factorial, involving genetic components and hitherto unknown environmental factors. The aim of the ... -
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers
(Journal article; Peer reviewed, 2022)Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid (CSF) reflect core features of the pathogenesis of Alzheimer’s disease (AD) more directly than clinical diagnosis. Initiated by the European ... -
Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma
(Journal article; Peer reviewed, 2021)Despite recent advances in the prevention of cervical cancer, the disease remains a leading cause of cancer-related deaths in women worldwide. By applying the GISTIC2.0 and/or the MutSig2CV algorithms on 430 whole-exome-sequenced ... -
Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas
(Journal article; Peer reviewed, 2021)Cervical cancer tumors with undetectable HPV (HPVU) have been underappreciated in clinical decision making. In this study, two independent CC datasets were used to characterize the largest cohort of HPVU tumors to date ... -
Genomic epidemiology of Streptococcus dysgalactiae subsp. equisimilis strains causing invasive disease in Norway during 2018
(Journal article; Peer reviewed, 2023)Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging global pathogen, yet the epidemiology and population genetics of SDSE species have not been extensively characterized. Methods: We ... -
The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy
(Journal article; Peer reviewed, 2023)The International prognostic Index (IPI) is the most widely used clinical prediction model for diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone ... -
Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms
(Journal article; Peer reviewed, 2023)High-grade gastroenteropancreatic (HG-GEP) neuroendocrine neoplasms (NENs) are highly aggressive cancers. The molecular etiology of these tumors remains unclear, and the prevalence of pathogenic germline variants in patients ...